Il-1 System and Sex Steroid Receptor Expression in Human Breast Cancer: Il-1alpha Protein Secretion Is Correlated With Malignant Phenotype

Singer, CF; Kronsteiner, Nicole; Hudelist, Gernot; Márton, Erika; Walter, Ingrid; Kubista, Marion; Czerwenka, K.; Schreiber, Martin; Seifert, Michael; Kubista, E.

doi:10.1136/ijgc-00009577-200303001-00301

Cited by 32 publications

(39 citation statements)

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“…Higher secretion of cytokines and growth factors, abnormal B cell function and antibody production, as well as local elevation of estrogen levels, are some conditions observed in endometriosis and probably favor cancer progression [28][29][30][31][32][33]. The scenario of an early interruption of such inflammatory process by oophorectomy that may contribute to a limited risk of BC was also investigated in some studies, whose results were discrepant [22][23][24].…”

Section: Discussionmentioning

confidence: 95%

Association of endometriosis and breast cancer: mini review of the literature

Anifantaki

Boutas

Kalampokas

et al. 2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 95%

Association of endometriosis and breast cancer: mini review of the literature

Anifantaki

Boutas

Kalampokas

et al. 2015

Arch Gynecol Obstet

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“…It downregulates the inflammatory response of cell-mediated immunity. In particular, IL-10 can inhibit DC differentiation from stem cell precursors 3 and compromise maturation and the functional status of DCs [83]. IL-10 also inhibits antigen presentation, IL-12 production and induction of T helper type 1 responses in vivo [147,148].…”

Section: Tumour and Host-related Mechanismsmentioning

confidence: 98%

“…The expression of IL-8 and other protumorigenic cytokines contribute to protumorigenic activities, i.e. angiogenesis, tumour proliferation and local tumour invasion [2][3]. IL-8 is a member of the angiogenesis CXC chemokine family [4] and a potent chemoattractant contributing to breast cancer progression as mitogenic, angiogenic and motogenic factor [5][6].…”

Section: Introductionmentioning

confidence: 99%

Cytokines in the Management of High Risk or Advanced Breast Cancer: An Update and Expectation

Carpi¹,

Nicolini²,

Antonelli³

et al. 2009

CCDT

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Some cytokines (interleukin (IL)-2, IL-11, transforming growth factor(TGF)beta) stimulate, while others (IL-12, IL-18, Interferons (IFNs)) inhibit breast cancer proliferation and/or invasion. So far IL-2, IFNalpha, IFNbeta and occasionally IFNgamma, IL-6, IL-12 have been used for the treatment of advanced breast cancer either to induce or increase hormone sensitivity and/or to stimulate cellular immunity. Only two long term pilot studies suggest that IL-2 and IFNbeta can improve clinical benefit and/or overall survival of metastatic breast cancer patients with minimal residual disease after chemotherapy or with disseminate disease non progressing during endocrine therapy. These results have been interpreted assuming that tumour microenvironment impairs the immune system of the host. Consequently, minimal disease or intense cytostatic effects following chemo or endocrine therapy, respectively, permit the patient's immune system to respond to the stimulatory effect of the cytokines. Therefore a prospective, phase III, randomised, simple blind trial has been planned. The aim is to assess whether the addition of IFNbeta and IL-2 to standard hormone therapy in postmenopausal patients with metastatic breast cancer and positive or unknown positive receptors prolongs the clinical benefit and survival since the metastatic diagnosis and the beginning of first line salvage antiestrogen therapy, compared with the results achieved with standard hormone therapy alone. If this immunotherapy prolongs survival of endocrine dependent metastatic breast cancer patients, IL-2 and IFNbeta can also be evaluated as adjuvant treatment of patients with positive estrogen receptors.

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“…4e. The IL-1 system appears to be vital in the local control of tumor growth [74], is important in regulating ''protumorigenic'' activities within the tumor microenvironment [75], and contributes to angiogenesis, tumor proliferation, and tumor invasion [76].…”

Section: Effects Of Genistein On Estrogen-responsive Genesmentioning

confidence: 99%

Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study

Lavigne

Takahashi

Chandramouli

et al. 2007

Breast Cancer Res Treat

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Breast cancer is the most commonly diagnosed cancer among US women; there is therefore great interest in developing preventive and treatment strategies for this disease. Because breast cancer incidence is much lower in countries where women consume high levels of soy, bioactive compounds in this food source have been studied for their effects on breast cancer. Genistein, found at high levels in soybeans and soy foods, is a controversial candidate breast cancer preventive phytochemical whose effects on breast cells are complex. To understand more clearly the molecular mechanisms underlying the effects of genistein on breast cancer cells, we used a DNA oligo microarray approach to examine the global gene expression patterns in MCF-7 breast cancer cells at both physiologic (1 or 5 microM) and pharmacologic (25 microM) genistein concentrations. Microarray analyses were performed on MCF-7 cells after 48 h of either vehicle or 1, 5, or 25 microM genistein treatment. We found that genistein altered the expression of genes belonging to a wide range of pathways, including estrogen- and p53-mediated pathways. At 1 and 5 microM, genistein elicited an expression pattern suggestive of increased mitogenic activity, confirming the proliferative response to genistein observed in cultured MCF-7 cells, while at 25 microM genistein effected a pattern that likely contributes to increased apoptosis, decreased proliferation and decreased total cell number, also consistent with cell culture results. These findings provide evidence for a molecular signature of genistein's effects in MCF-7 cells and lay the foundation for elucidating the mechanisms of genistein's biological impact in breast cancer cells.

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Il-1 System and Sex Steroid Receptor Expression in Human Breast Cancer: Il-1alpha Protein Secretion Is Correlated With Malignant Phenotype

Cited by 32 publications

References 0 publications

Association of endometriosis and breast cancer: mini review of the literature

Association of endometriosis and breast cancer: mini review of the literature

Cytokines in the Management of High Risk or Advanced Breast Cancer: An Update and Expectation

Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study

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