IL-04 The role of kit-ligand presentation in the development of the epidermal melanocyte niche

Wehrle-Haller, Bernhard; Paulhe, Frédérique; Jacquier, Marie-Claude; Rossier, C.; Wehrle-Haller, Monique; Imhof, Beat A.

doi:10.1034/j.1600-0749.2003.00837.x

Cited by 1 publication

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“…In a healthy individual, the MAPK cascade is activated by the binding of specific and extrinsic growth factors to transmembrane receptor tyrosine kinases (RTKs), with c‐Kit—also known as mast/stem cell growth factor receptor (SCFR) or cluster of differentiation 117 (CD117)—being the most important one 14. This receptor is activated by the stem cell factor (SCF), a cytokine that also plays a key role in determining the localization of skin melanocytes 15. Some studies point to the presence of several types of mutations in the c‐Kit gene, which may suggest that c‐Kit inhibition could be useful in certain genetic contexts (see section 4.3. c‐Kit inhibitors below) 16…”

Section: Altered Signaling Pathways In Melanoma Cellsmentioning

confidence: 99%

Improvement of a Gas Intake Device and a Gas Mixing Study in a Large‐Scale Vessel

Chen

Fan

2014

Chem Eng & Technol

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Gas mixing is a common process in chemical engineering. For actual industrial manufacturing of chemicals, most reactions commonly run in reactors or reaction vessels with large volumes (over 10 m3). In order to simulate a gas mixing process in a sealed reactor, and finally to improve the mixing effect between the gases, here the mixing process between methane and air in a reaction vessel with a volume of 10 m3 was studied via several approaches. Several specific evaluation indexes, including the mixing degree, the maximum concentration difference, and the mixing time, were obtained and recorded to evaluate the mixing effect on the gases. After a series of experiments targeting the determination of the size and pressure difference values of the gas intake device, the mixing effect between methane and air was finally optimized. The mixing degree was found to reach 0.97 within 1 h of monitoring, and the mixing time was decreased by 1700 % from the original situation.

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Section: Altered Signaling Pathways In Melanoma Cellsmentioning

confidence: 99%