Ikke nødvendig med høydosetilskudd av vitamin D

Holvik, Kristin; Meyer, Haakon E; Madar, Ahmed A.; Brustad, Magritt

doi:10.4045/tidsskr.18.0749

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…In 2013, the Nordic Nutrition Recommendations experts recommended vitamin D supplementation in wintertime for the general population [16]. A tremendous interest in possible health effects of vitamin D beyond its regulation of the bone metabolism and a considerable increase of users of prescription-only vitamin D supplements and over-thecounter dietary supplements have been observed over the past decade [23]. As the present population-based study, enrolling rectal cancer patients between 2013 and 2017, demonstrated seasonal variation in circulating 25(OH) D only in men, one can speculate that women might have changed habits towards better vitamin D status over the entire calendar year.…”

Section: Discussionmentioning

confidence: 99%

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Abrahamsson

Meltzer

Hagen

et al. 2021

Preprint

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Background: We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH)D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients.Methods: Serum 25(OH)D at the time of diagnosis was assessed in 129 patients, enrolled 2013-2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival.Results: In the population-based cohort residing at latitude 60°N, 25(OH)D varied according to season in men only, who were overrepresented among the vitamin D-deficient (<50 nmol/L) patients. Consistent with our previous findings, the individuals presenting with T4 disease had significantly reduced 25(OH)D levels. Low vitamin D was associated with systemic inflammation, albeit with distinct modes of presentation. While men with low vitamin D showed circulating markers typical for the systemic inflammatory response (e.g., elevated erythrocyte sedimentation rate), the corresponding female patients had elevated serum levels of interleukin-6 and the chemokine (C-X-C motif) ligand 7. Despite disparities in vitamin D status and the potential effects on disease attributes, significantly shortened cancer-specific survival was observed in vitamin D-deficient patients irrespective of sex.Conclusion: This unselected rectal cancer cohort confirmed the interconnection of low vitamin D, more advanced disease presentation, and poor survival, and further suggested it may be conditional on disparate modes of adverse systemic inflammation in men and women.Trial registration: ClinicalTrials.gov NCT01816607; registration date: 22 March 2013.

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Section: Discussionmentioning

confidence: 99%

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Abrahamsson

Meltzer

Hagen

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer

et al. 2021

View full text Add to dashboard Cite

Background We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH) D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients. Methods Serum 25(OH) D at the time of diagnosis was assessed in 129 patients, enrolled 2013–2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival. Results In the population-based cohort residing at latitude 60°N, 25(OH) D varied according to season in men only, who were overrepresented among the vitamin D-deficient (< 50 nmol/L) patients. Consistent with our previous findings, the individuals presenting with T4 disease had significantly reduced 25(OH) D levels. Low vitamin D was associated with systemic inflammation, albeit with distinct modes of presentation. While men with low vitamin D showed circulating markers typical for the systemic inflammatory response (e.g., elevated erythrocyte sedimentation rate), the corresponding female patients had elevated serum levels of interleukin-6 and the chemokine (C-X-C motif) ligand 7. Despite disparities in vitamin D status and the potential effects on disease attributes, significantly shortened cancer-specific survival was observed in vitamin D-deficient patients irrespective of sex. Conclusion This unselected rectal cancer cohort confirmed the interconnection of low vitamin D, more advanced disease presentation, and poor survival, and further suggested it may be conditional on disparate modes of adverse systemic inflammation in men and women. Trial registration ClinicalTrials.govNCT01816607; registration date: 22 March 2013.

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Challenges Ahead for a Rational Analysis of Vitamin D in Athletes

Araujo

Méndez-Dávila

2021

Front. Nutr.

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Vitamin D is an essential vitamin for the normal formation of bones and calcium absorption. It is synthesized into our body through sunlight exposure and obtained by consuming foods rich in vitamin D (e.g., fatty fish, eggs yolk, dairy products). Its benefits on the health and performance of athletes are well documented. This article outlines some analytical challenges concerning the analytical quantification of vitamin D for its optimal intake, namely, a comprehensive study of the variability of the assay before categorizing any method as the golden standard, assurance of sample comparability to draw meaningful correlations, revision of the intake guidance based on appropriate statistical power analysis, and the implementation of rational strategies for preventing the underlying mechanism of preanalytical factors. Addressing these challenges will enable the effective management of vitamin D in the sports sector.

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Ikke nødvendig med høydosetilskudd av vitamin D

Cited by 3 publications

References 12 publications

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Sex Disparities in Vitamin D Status and the Impact on Systemic Inflammation and Survival in Rectal Cancer

Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer

Challenges Ahead for a Rational Analysis of Vitamin D in Athletes

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