Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Patrick A. H. Ehm,
Stefan Horn,
Konstantin Hoffer
et al.
Abstract:Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection. Here, we show that SHIP1 is differentially expressed across B-ALL subtypes and that high versus low SHIP1 expression is associated with specific B-ALL subgroups. In particular, we found high SHIP1 e… Show more
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