Iindoxyl Sulfate, A Tryptophan Metabolite, Induces Nephro-Vascular Toxicity

Niwa, Toshimitsu

doi:10.5504/50yrtimb.2011.0024

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…20 Conventional treatments show that indoxyl sulfate clearance significantly lags behind ureas. 21 These heightened levels of indoxyl sulfate in dialysis patients-sometimes reported to be up to 80 times higher than in healthy controls 22 have grave implications for cognitive health. The impaired renal transport mechanisms in CKD facilitate the accumulation of indoxyl sulfate in the brain.…”

Section: Discussionmentioning

confidence: 99%

Indoxyl Sulphate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients

Syafrita,

Susanti,

Indra

et al. 2023

Glob Med Health Commun

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Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate. Although it's known that indoxyl sulfate has harmful effects on intra or extra-kidney organs, its impact on executive function remains unclear. This study aimed to evaluate indoxyl sulfate levels in patients with chronic kidney disease (CKD) undergoing hemodialysis and to understand its correlation with executive function impairments. This observational cross-sectional study was conducted at the Dr. M. Djamil General Hospital Padang Hemodialysis Unit from March to July 2022; 60 patients undergoing hemodialysis and 20 healthy controls participated. Executive function was assessed using the Trail Making Test B (TMT-B). Indoxyl sulfate levels were quantified using an ELISA assay with the Assay Genie kit. The Mann-Whitney test set statistical significance at a p<0.05. The average age of the subjects was 51.4±11.4 years, with 53.3% being male. The mean indoxyl sulfate levels were considerably higher in the CKD group (118.79 ng/mL, range: 11–1,709 ng/mL) compared to the control group (6.028±1.829 ng/mL), with a significant difference (p<0.001). Impaired executive function was observed in 75% of the CKD patients. The average indoxyl sulfate level was 165.12 ng/mL (range: 29–1709 ng/mL) in the impaired executive function group and 71.22 ng/mL (range: 11–333 ng/mL) in the group with normal executive function, indicating a significant difference (p=0.013). Patients with CKD undergoing hemodialysis exhibit elevated serum indoxyl sulfate levels compared to healthy individuals. Moreover, CKD patients with impaired executive function have notably higher indoxyl sulfate levels than those with normal executive function. Further research is needed to elucidate the mechanistic links between indoxyl sulfate and cognitive impairments.

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Section: Discussionmentioning

confidence: 99%

Indoxyl Sulphate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients

Syafrita,

Susanti,

Indra

et al. 2023

Glob Med Health Commun

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Association between chronic kidney disease and Alzheimer’s disease: an update

Zhang

et al. 2020

Metab Brain Dis

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Hazard Identification Related to the Presence of Vibrio spp., Biogenic Amines, and Indole-Producing Bacteria in a Non-Filter Feeding Marine Gastropod (Tritia mutabilis) Commercialized on the Italian Market

Serratore

Bignami

Ostanello

et al. 2021

Foods

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Tritia mutabilis is a carrion-feeder edible marine gastropod with an open circulatory system. Therefore, biological, and chemical contaminants associated with the feed can reach all body tissues. The aim of the present study was to investigate the possible association of these characteristics with some food safety hazards. Vibrio spp. load, and the prevalence of pathogenic V. parahaemolyticus, V. vulnificus, and V. cholerae, were investigated. Moreover, biogenic amines (BAs) and indole-producing bacteria (IPB), markers of seafood decomposition, were quantified for the first time in an edible carrion-feeder. Overall, 49 batches were analyzed (38 from retail, and 11 from primary production). The Vibrio spp. load resulted of 5.64 ± 0.69 log10 CFU g−1 at retail, and 5.27 ± 0.74 at harvest but all batches resulted negative for pathogenic Vibrio. Histamine, putrescine, cadaverine, and tyramine were detected both at harvest and at the retail level. Their sum (BAs Index) showed a mean value of 50.45 and 65.83 mg Kg−1 in batches at harvest and at retail, respectively. IPB were detected at harvest and upon refrigeration for three days (T1–T3). The mean load resulted in 2.52 ± 0.85 log10 MPN g−1 at T0, 3.31 ± 1.23 at T3 in batches immediately refrigerated, and 3.22 ± 1.18 at T3 in batches previously immersed in clean seawater. Our results contribute to identifying food-borne hazards for T. mutabilis that may be related to the retention of biogenic amines and indole-producing bacteria due to carrion feeding.

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Iindoxyl Sulfate, A Tryptophan Metabolite, Induces Nephro-Vascular Toxicity

Abstract: ABSTRACT

Cited by 3 publications

References 43 publications

Indoxyl Sulphate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients

Indoxyl Sulphate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients

Association between chronic kidney disease and Alzheimer’s disease: an update

Hazard Identification Related to the Presence of Vibrio spp., Biogenic Amines, and Indole-Producing Bacteria in a Non-Filter Feeding Marine Gastropod (Tritia mutabilis) Commercialized on the Italian Market

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