III. Albendazole in the treatment of inoperable hydatid disease in Kenya—a report on 12 cases

Okelo, G. B. A.

doi:10.1016/0035-9203(86)90005-2

Cited by 32 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the timing of lung-cyst rupture varied considerably, from just 10 days to 2 months after the initiation of treatment (Table 3). The timing of some lung-cyst changes was noted, in passing, by other researchers investigating the effects of MBZ (Kern et al, 1979;Shivashankar et al, 1982) or ABZ (Okelo, 1986).…”

Section: Pulmonary Cystsmentioning

confidence: 80%

The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis

Todorov

Vutova

Donev

et al. 2005

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

In a large-scale Bulgarian study, 122 patients with abdominal and/or lung echinococcosis were randomly selected for treatment with albendazole or mebendazole. The main aims were to evaluate the effect of each drug on the hydatid cysts, to follow the changes in cyst morphology during and after treatment, and to determine how quickly each drug produced the first, detectable, degenerative changes in the cysts. Follow-up was based on periodic ultrasonography, chest radiography and computed tomography. The abdominal cysts were categorised as small (<5 cm in diameter) or large. As albendazole treatment had effects that were almost identical to those of mebendazole treatment, the results for the two drugs were combined. In the lungs and, particularly, in the abdomen, the size of the cysts being treated influenced the character and timing of the degenerative changes seen in them. The initial change seen in each abdominal cyst was detachment of the endocyst, which occurred 1-3 months (small cysts) or 2-5 months (large cysts) after the initiation of treatment (P<0.05). The abdominal cysts then developed a hyper-echoic/hyper-dense appearance, became smaller, and finally disappeared 3.3-9.3 months (small cysts) or 5.6-13.9 months (large cysts) after treatment began (P<0.05). The first degenerative change noted in the lung cysts was cyst rupture, which occurred as early as day 10 of therapy but was generally observed 1 or 2 months after treatment began. After their complete evacuation, the ruptured lung cysts shrank and became deformed, some disappearing within 5-9 months of the initiation of treatment. The degenerative changes recorded, which began significantly earlier in the lung cysts than in abdominal cysts, indicate serious damage to the cysts and the parasiticidal, curative effect of each of the two benzimidazoles employed.

show abstract

Section: Pulmonary Cystsmentioning

confidence: 80%

The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis

Todorov

Vutova

Donev

et al. 2005

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

show abstract

“…Albendazole is an experimental benzimidazole anthelmintic with demonstrated efficacy in Necator americanus infections (18). hydatid disease (19). ascaris and trichu ris in fections (20), and strongyloidiasis (21).…”

Section: Discussionmentioning

confidence: 99%

Praziquantel Failure in the Treatment of Fasciola hepatica

Patrick

Isaac-Renton²

1990

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

A case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the life cycle and pathogenesis of the parasite. It is concluded that while bithionol remains the current drug of choice, triclabendazole may play a dominant role in the near future.

show abstract

“…Surgery remains the treatment of choice. [102][103][104][105][106][107][108][109][110][111][112][113] Since pulmonary cysts of the sylvatic type have a propensity to spontaneous rupture and superinfection, they should be excised (or sterilized and drained) even when the host is asymptomatic. A careful search for hepatic lesions should be made prior to surgery because many patients will have subdiaphragmatic hydatids that can be approached through the same thoracotomy.…”

Section: Managementmentioning

confidence: 99%

“…A number of studies have looked at the suitability of treating inoperable echinococciasis with anthelmintics. [110][111][112][113] Despite praziquantel's documented scolicidal activity, it is still not known if it is lethal to germinal layer cells. 107 For that reason clinical studies have focused on the benzimidazole carbamates: mebendazole, albendazole, and flubendazole.…”

mentioning

confidence: 99%