II. The effects of the exclusion of its regional sources of supply on the sciatic nerve of the rabbit

Adams, William E.

doi:10.1093/oxfordjournals.bmb.a070234

Cited by 39 publications

(21 citation statements)

References 3 publications

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“…They provided mathematical modelling to demonstrate its feasibility but provided no experimental data. Earlier experimental data demonstrated that peripheral nerve fibre degeneration did not occur even when long stretches of nerve were deprived of their intrinsic supply either by arterial ligation (Adams, 1943;Denny-Brown & Brenner, 1944;Blunt & Stratton, 1956) or by extensive nerve trunk mobilization with undercutting of connecting blood supply (Blunt & Stratton, 1956;Lundborg, 1970). However, the focus of these studies was on the effect of arterial, rather than arteriolar, occlusion.…”

Section: Discussionmentioning

confidence: 99%

Regulation of rat nerve blood flow: role of epineurial alpha‐receptors.

Kihara

Low

1990

The Journal of Physiology

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SUMMARY1. Transperineurial arterioles connect the extrinsic (epineurial) and the intrinsic (endoneurial) microvasculatures. Our goal was to determine whether the extrinsic system regulated nerve blood flow locally and whether subperineurial and centrifascicular endoneurial nerve blood flows were regulated differentially.2. The local application of noradrenaline resulted in a dose-dependent reduction of nerve blood flow in subjacent endoneurium. Asymptotes of 78-8 and 763 % vasoconstriction were recorded for subperineurial and centrifascicular endoneurial nerve blood flow, respectively, indicating near-complete closure of capillaries.3. Near-identical concentrations required to generate 50 % vasoconstriction (EC,50) and asymptotes are suggestive of the fact that the two areas are not differentially regulated.4. Local vasoconstriction cannot be due to a systemic effect of noradrenaline since a significant decrease in nerve blood flow occurs despite undetectable increases in plasma noradrenaline and mean blood pressure, or decrease in contralateral sciatic nerve blood flow.5. There are small and statistically non-significant reductions of the compound muscle action potential and conduction velocity in the sciatic-tibial nerve following nerve ischaemia.6. These findings suggest that epineurial arterioles control regional nerve blood flow and are primarily responsible for its regulation in subjacent endoneurial tissue.

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Section: Discussionmentioning

confidence: 99%

Regulation of rat nerve blood flow: role of epineurial alpha‐receptors.

Kihara

Low

1990

The Journal of Physiology

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“…Sciatic nerve, common peroneal nerve and superficial branch of common peroneal nerve were carefully separated from the surrounding tissues with the help of glass hook. Nerve trauma in this model was thoroughly avoided [14,15].…”

Section: Nerve Injury Modelsmentioning

confidence: 99%

Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration

Karagyaur¹,

Dyikanov²,

Макаревич³

et al. 2015

Biomedicine & Pharmacotherapy

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“…Thus, because Doppler ultrasound is limited to a single epineurial vessel, it may not capture reductions in endoneurial-specific flow. However, the sciatic nerve contains feed arteries originating from multiple locations that do not necessarily branch into a capillary plexus and has been described as an anastomotic vascular network that may contain bidirectional flow (3,9,70). Such a pattern of tissue perfusion limits the interpretation of gross flow measurements and highlights the benefit of quantifying exclusive arterial inflow responses.…”

Section: Studymentioning

confidence: 99%

Exercise training enhances insulin-stimulated nerve arterial vasodilation in rats with insulin-treated experimental diabetes

Olver

McDonald

Grisé

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Insulin stimulates nerve arterial vasodilation through a nitric oxide (NO) synthase (NOS) mechanism. Experimental diabetes reduces vasa nervorum NO reactivity. Studies investigating hyperglycemia and nerve arterial vasodilation typically omit insulin treatment and use sedentary rats resulting in severe hyperglycemia. We tested the hypotheses that 1) insulin-treated experimental diabetes and inactivity (DS rats) will attenuate insulin-mediated nerve arterial vasodilation, and 2) deficits in vasodilation in DS rats will be overcome by concurrent exercise training (DX rats; 75-85% VO2 max, 1 h/day, 5 days/wk, for 10 wk). The baseline index of vascular conductance values (VCi = nerve blood flow velocity/mean arterial blood pressure) were similar (P ≥ 0.68), but peak VCi and the area under the curve (AUCi) for the VCi during a euglycemic hyperinsulinemic clamp (EHC; 10 mU·kg(-1)·min(-1)) were lower in DS rats versus control sedentary (CS) rats and DX rats (P ≤ 0.01). Motor nerve conduction velocity (MNCV) was lower in DS rats versus CS rats and DX rats (P ≤ 0.01). When compared with DS rats, DX rats expressed greater nerve endothelial NOS (eNOS) protein content (P = 0.04). In a separate analysis, we examined the impact of diabetes in exercise-trained rats alone. When compared with exercise-trained control rats (CX), DX rats had a lower AUCi during the EHC, lower MNCV values, and lower sciatic nerve eNOS protein content (P ≤ 0.03). Therefore, vasa nervorum and motor nerve function are impaired in DS rats. Such deficits in rats with diabetes can be overcome by concurrent exercise training. However, in exercise-trained rats (CX and DX groups), moderate hyperglycemia lowers vasa nervorum and nerve function.

show abstract

II. The effects of the exclusion of its regional sources of supply on the sciatic nerve of the rabbit

Cited by 39 publications

References 3 publications

Regulation of rat nerve blood flow: role of epineurial alpha‐receptors.

Regulation of rat nerve blood flow: role of epineurial alpha‐receptors.

Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration

Exercise training enhances insulin-stimulated nerve arterial vasodilation in rats with insulin-treated experimental diabetes

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