II Diretriz brasileira de cardiopatia grave

Dutra, Óscar Pereira

doi:10.1590/s0066-782x2006001500024

Cited by 18 publications

(12 citation statements)

References 24 publications

(5 reference statements)

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“…Patients who presented a normal ECG were classified as patients without CCC and patients with electrocardiographic changes, common to CCC, were classified as patients with CCC. The severity of the LVSD was measured according to the left ventricular ejection fraction (LVEF) and the Teichhoolz method was applied following the II Brazilian Guideline for Severe Heart Diseases [19]. Patients with CCC were classified considering the (LVEF) in three different groups: patients without LVSD (LVEF > 60%); patients with mild to moderate LVSD (LVEF 40–60%); and patients with severe LVSD (LVEF < 40%).…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms ofIL17and Chagas Disease in the South and Southeast of Brazil

Reis

Ayo

Mattos

et al. 2017

Journal of Immunology Research

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The aim of this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. The genotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups (patients with CCC; patients with CCC and LVSD; and patients with CCC and severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was higher in male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.

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Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms ofIL17and Chagas Disease in the South and Southeast of Brazil

Reis

Ayo

Mattos

et al. 2017

Journal of Immunology Research

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show abstract

“…Patients were divided into groups according to LVEF; without LVSD was diagnosed in patients with a LVEF ≥60%, mild LVSD in those with LVEF <60% and ≥40%, and severe LVSD in those with LVEF <40%, with the last group being defined according to the Brazilian guidelines of severe chronic heart disease [ 23 ]. In cases where LVEF was measured by Radionuclide Ventriculography, patients with LVEF >50%, LVEF between 30% and 50% and LVEF <30%, indicated normal left ventricular systolic function, mild to moderate, and severe LVSD, respectively.…”

Section: Methodsmentioning

confidence: 99%

Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism

et al. 2015

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The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the variable clinical course of this disease are known. This study investigated whether the CCR5Δ32 (rs333) and CCR5 59029 A/G (promoter region—rs1799987) polymorphisms of the CCR5 gene are associated with different clinical forms of chronic Chagas disease and with the severity of left ventricular systolic dysfunction in patients with chronic Chagas heart disease (CCHD). The antibodies anti-T. cruzi were identified by ELISA. PCR and PCR-RFLP were used to identify the CCR5Δ32 and CCR5 59029 A/G polymorphisms. The chi-square test was used to compare variables between groups. There was a higher frequency of the AA genotype in patients with CCHD compared with patients with the digestive form of the disease and the control group. The results also showed a high frequency of the AG genotype in patients with the digestive form of the disease compared to the other groups. The results of this study show that the CCR5Δ32 polymorphism does not seem to influence the different clinical manifestations of Chagas disease but there is involvement of the CCR5 59029 A/G polymorphism in susceptibility to the different forms of chronic Chagas disease. Besides, these polymorphisms do not influence left ventricular systolic dysfunction in patients with CCHD.

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“…All patients underwent 2-dimensional echocardiogram. The severity of LVSD was graded according to left ventricular ejection fraction (LVEF) values measured with the Teichholz method according to the Brazilian guidelines of severe chronic heart disease [ 6 ]. Patients were classified into the following 3 groups according to LVEF: LVEF > 60% (patients without LVSD), LVEF between 60% and 40% (patients with mild to moderate LVSD), and LVEF < 40% (patients with severe LVSD) ( Supplementary Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease: Table 1.

Ayo¹,

Oliveira²,

Camargo³

et al. 2015

Clin Infect Dis.

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II Diretriz brasileira de cardiopatia grave

Abstract: C o r r e s p o n d ê n c i a : O s c a r P e r e i r a D u t r a • R u a P r i n c e s a I s a b e l , 3 9 5 -9 0 6 2 0 -0 0 1 -P o r t o A l e g r e , R S

Cited by 18 publications

References 24 publications

Genetic Polymorphisms ofIL17and Chagas Disease in the South and Southeast of Brazil

Genetic Polymorphisms ofIL17and Chagas Disease in the South and Southeast of Brazil

Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism

Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease: Table 1.

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