II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

Pollak, Felipe; Araya, Verónica; Lanas, Alejandra; Sapunar, J; Arrese, Marco; Aylwin, Carmen Gloria; Bezanilla, Carmen Gloria; Carrasco, Elena; Carrasco, Fernando; Codner, Ethel; Díaz, Erik; Durruty, P; Galgani, José E.; García, Hernán; Lahsen, Rodolfo; Liberman, Claudio; López, Gloria; Maíz, Alberto; Mujica, Verónica; Poníachik, Jaime; Sir, Teresa; Soto, Néstor; Valderas, Juan P.; Villaseca, Paulina; Zavala, C

doi:10.4067/s0034-98872015000500012

Cited by 16 publications

(22 citation statements)

References 73 publications

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“…El II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre RI, comunicado en 2015 29 , no recomienda la medición de insulina en la práctica clínica, considerando las limitaciones del método y la falta de validación para población pediátrica. Nuestros resultados muestran que 72% de los escolares con obesidad tienen hiperinsulinismo, según criterio de Burrows, pero solo 18% de estos califican para SM.…”

Section: Discussionunclassified

Alta prevalencia de trastornos nutricionales por exceso, resistencia insulínica y síndrome metabólico en escolares de la comuna de Carahue, Región de la Araucanía

et al. 2018

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High prevalence of overweight, obesity, insulin resistance and metabolic syndrome in rural children and adolescents Background: Childhood and adolescent obesity is a major public health problem in Chile. Aim: To characterize cardiometabolic risk factors in a population of schoolchildren from Carahue, Chile. Material and Methods: Cross-sectional assessment of 208 children aged 10.4 ± 1.0 years (106 women). A clinical evaluation was carried out including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure glucose, insulin and lipid profile. HOMA-IR and Quicki indices were calculated. Insulin resistance (IR) was established according to Burrows criteria and Barja criteria, previously proposed for the Chilean pediatric population. The metabolic syndrome (MetS) was established using the modified Cook criteria. Results: Thirty eight percent of children had overweight and 33.1% obesity. MetS was only observed in obese subjects and the frequency in this subgroup was 38%. The prevalence of IR was 51% according to the Burrows criteria and 19% according to Barja criteria. It was more common in participants who were overweight, obese or had abdominal obesity. Children with insulin resistance according to Barja criteria, had worse anthropometric measures than their counterparts without resistance. When Burrows criteria was used, no differences in anthropometric measures were observed between participants with or without resistance. The frequency of MetS was 26 and 18% in children with insulin resistance according to Barja and Burrows criteria, respectively. Insulin levels and insulin sensitivity indexes were positively correlated with anthropometric parameters. Conclusions: There was a high prevalence of overweight, obesity and MetS in these participants. Our results suggest that the IR criteria according to Barja allows to identify cases with higher metabolic risk.

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Section: Discussionunclassified

Alta prevalencia de trastornos nutricionales por exceso, resistencia insulínica y síndrome metabólico en escolares de la comuna de Carahue, Región de la Araucanía

et al. 2018

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“…The higher insulin in carriers of the risk haplotype does not represent a true hyperinsulinemic state (e.g. > 15 mIU/L) (27); rather, it is related directly to the nutritional state because the association was lost when it was adjusted for BMI in Model 3. Nevertheless, it is interesting to note that the increase BMI and insulin were not accompanied by significant increases in HOMA IR , indicating a lack of association with insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population

Mardones

Petermann-Rocha

Martínez-Sangüinetti

et al. 2021

Archives of Endocrinology and Metabolism

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Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 nondiabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMA IR , leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression. Results: The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI: 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI: 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of sociodemographic variables. Conclusion: The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.

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“…El común denominador del aumento de la grasa (35) corporal es la resistencia a la insulina . La mayoría de los pacientes de esta muestra se hallaba en (36) tratamiento con metformina, lo cual resulta apropiado . Este estudio no tenía como objetivo determinar las causas de mal control glucémico, tema pendiente de investigación.…”

Section: Multidisciplinariosunclassified

Glycemic control of diabetic patients in two Family Health Units, Paraguay, 2018. Pilot study

Gabetta

Amarilla

Rivelli

et al. 2019

Rev. virtual Soc. Parag. Med. Int

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RESUMENIntroducción: la diabetes mellitus (DM) es una enfermedad prevalente en el Paraguay y el tratamiento adecuado exige un control glucémico estricto. Objetivos: determinar la frecuencia de control glucémico adecuado en diabéticos de tres Unidades de Salud Familiar de Areguá, Paraguay. Metodología: diseño observacional, prospectivo que incluyó a varones y mujeres adultos, portadores de DM en tres Unidades de Salud Familiar de Areguá y Asunción, Paraguay, en 2018. Se midieron variables antropométricas, clínicas y laboratoriales. La glucemia en ayunas fue obtenida por glucómetro. Resultados: se incluyó a 111 diabéticos, 97% de tipo 2. La edad media fue 62±9 años y predominó el sexo femenino (70%). La frecuencia de diabéticos con hemoglobina glicada <7% fue 56%. La preobesidad y obesidad juntas se observaron en 71%. La comorbilidad más frecuente fue la hipertensión arterial (87%). El mal control glucémico se asoció significativamente al sedentarismo y bajo ingreso económico. Conclusiones: el control glucémico adecuado determinado por la hemoglobina glicada fue 56%. Se requieren estudios en mayores muestras para determinar las causas de falta de control glucémico en los diabéticos de las Unidades de Salud Familiar. ABSTRACT Introduction: Diabetes mellitus (DM) is a prevalent disease in Paraguay and proper treatment requires strict glycemic control. Objectives: To determine the frequency of adequate glycemic control in diabetics of three Family Health Units in Areguá, Paraguay.Methodology: Observational, prospective design that included adult men and women, carriers of DM in three Family Health Units of Areguá and Asunción, Paraguay in 2018. Anthropometric, clinical and laboratorial variables were measured. Fasting blood glucose was obtained by a glucometer. Results: One hundred eleven diabetics were included, 97% of type 2. The average age was 62±9 years and the female sex predominated (70%). The frequency of diabetics with glycated hemoglobin <7% was 56%. The pre-obesity and obesity together were observed in 71%. The most frequent comorbidity was arterial hypertension (87%). Poor glycemic control was significantly associated with sedentary lifestyle and low income. Conclusions: The adequate glycemic control determined by the glycated hemoglobin was 56%. Studies in larger samples are required to determine the causes of lack of glycemic control in diabetics of Family Health Units.

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II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

Cited by 16 publications

References 73 publications

Alta prevalencia de trastornos nutricionales por exceso, resistencia insulínica y síndrome metabólico en escolares de la comuna de Carahue, Región de la Araucanía

Alta prevalencia de trastornos nutricionales por exceso, resistencia insulínica y síndrome metabólico en escolares de la comuna de Carahue, Región de la Araucanía

Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population

Glycemic control of diabetic patients in two Family Health Units, Paraguay, 2018. Pilot study

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