IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice

Li, Bo; Yan, Yaping; He, Yu‐Ying; Chen, Liang; Li, Mengyuan; Wang, Ying; Yang, Zeng‐Ming

doi:10.1126/scisignal.add0645

Cited by 7 publications

(3 citation statements)

References 94 publications

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“…1). Li et al 50 found that blastocyst-derived TNFα induces epithelial IHH, which stimulates expression of SHH in the stroma and thereby augments decidualization. Chen et al 51 further discovered that TNFα produced by the embryo promotes release of arachidonic acid from the epithelium to ignite fibroblast activation and decidualization through PGI2 and PPARδ.…”

Section: In Micementioning

confidence: 99%

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Basic Research Advances in China on Embryo Implantation, Placentation, and Parturition

Bao,

Wang

2024

Maternal Fetal Med

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This review aimed to summarize the major progress in maternal-fetal medicine achieved by Chinese scientists in recent years. PubMed was systematically searched from January 2020 to November 2023. Publications that reported the progress in embryo implantation, placentation, and parturition made by Chinese scientists in the last 3 years were selected. The milestone events during gestation, embryo implantation, endometrial decidualization, placentation, and parturition are pivotal to a successful pregnancy. Embryo implantation requires intricate interactions between implantation-competent blastocysts and receptive endometrium. To adapt to pregnancy, endometrial stromal cells transform into specialized decidual cells, which occur spontaneously under the influence of ovarian hormones in humans but require the presence of embryos in mice. With embryonic development, the placenta forms to support fetal growth until parturition. The maternal-fetal interface is composed of diverse cell types, including endometrial decidual cells, placental trophoblast cells, endothelial cells, and various immune cells, a sophisticated interplay among which contributes to the maintenance of pregnancy. Near term, the uterus transitions from quiescence to contractility, in preparation for delivery. Disruptions to these events lead to pregnancy-related disorders such as repeated implantation failure, recurrent pregnancy loss, preeclampsia, fetal growth restriction, preterm birth, and infertility. In recent years, Chinese scientists have made prominent achievements in basic research on the aforementioned pregnancy events. Chinese scientists have made remarkable contributions to reproductive biology and maternal-fetal medicine research in recent years, highlighting future research directions in this field.

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Section: In Micementioning

confidence: 99%

“…1). Li et al 50 . found that blastocyst-derived TNFα induces epithelial IHH, which stimulates expression of SHH in the stroma and thereby augments decidualization.…”

Section: Recent Progress In Endometrial-decidual Transformation Resea...mentioning

confidence: 99%

Basic Research Advances in China on Embryo Implantation, Placentation, and Parturition

Bao,

Wang

2024

Maternal Fetal Med

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“…Research has demonstrated the presence of primary cilia in human endometrial stromal cells. Within stromal cells, Sonic Hedgehog (SHH) stimulates the canonical Hedgehog (Hh) signaling pathway via primary cilia and facilitates decidualization through mechanisms implicating interleukin-11 (IL-11) and primary cilia ( Li et al, 2023 ). Mounting evidence suggests that impaired decidualization is closely associated with Recurrent Implantation Failure (RIF).…”

Section: Primary Cilia and Reproductive System-related Disordersmentioning

confidence: 99%

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Long,

Chen,

Xiao

et al. 2024

Front. Cell Dev. Biol.

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Primary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses. Their ubiquitous presence in the reproductive system underscores their pivotal roles in various cellular processes including development, differentiation, and migration. Emerging evidence suggests primary cilia as key players in reproductive physiology and associated pathologies. Notably, primary cilia have been identified in granulosa cells within mouse ovaries and uterine stromal cells, and perturbations in their structure and function have been implicated in a spectrum of reproductive dysfunctions and ciliary-related diseases. Furthermore, disruptions in primary cilia-mediated signal transduction pathways under pathological conditions exacerbate the onset and progression of reproductive disorders. This review provides a comprehensive overview of current research progress on primary cilia and their associated signaling pathways in reproductive physiology and diseases, with the aim of furnishing theoretical groundwork for the prevention and management of primary cilia-related structural and functional abnormalities contributing to reproductive system pathologies.

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Primary cilia abnormalities participate in the occurrence of spontaneous abortion through TGF‐β/SMAD2/3 signaling pathway

Yu,

Li,

Ning

et al. 2024

Journal Cellular Physiology

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Spontaneous abortion is the most common complication in early pregnancy, the exact etiology of most cases cannot be determined. Emerging studies suggest that mutations in ciliary genes may be associated with progression of pregnancy loss. However, the involvement of primary cilia on spontaneous abortion and the underlying molecular mechanisms remains poorly understood. We observed the number and length of primary cilia were significantly decreased in decidua of spontaneous abortion in human and lipopolysaccharide (LPS)‐induced abortion mice model, accompanied with increased expression of proinflammatory cytokines interleukin (IL)−1β, IL‐6, and tumor necrosis factor (TNF)‐α. The length of primary cilia in human endometrial stromal cell (hESC) was significantly shortened after TNF‐α treatment. Knocking down intraflagellar transport 88 (IFT88), involved in cilia formation and maintenance, promoted the expression of TNF‐α. There was a reverse regulatory relationship between cilia shortening and TNF‐α expression. Further research found that shortened cilia impair decidualization in hESC through transforming growth factor (TGF)‐β/SMAD2/3 signaling. Primary cilia were impaired in decidua tissue of spontaneous abortion, which might be mainly caused by inflammatory injury. Primary cilia abnormalities resulted in dysregulation of TGF‐β/SMAD2/3 signaling transduction and decidualization impairment, which led to spontaneous abortion.

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IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice

Cited by 7 publications

References 94 publications

Basic Research Advances in China on Embryo Implantation, Placentation, and Parturition

Basic Research Advances in China on Embryo Implantation, Placentation, and Parturition

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Primary cilia abnormalities participate in the occurrence of spontaneous abortion through TGF‐β/SMAD2/3 signaling pathway

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