IGSTK: a software toolkit for image-guided surgery applications

Cleary, Kevin; Ibáñez, Luis; Ranjan, Sohan; Blake, M. Brian

doi:10.1016/j.ics.2004.03.038

Cited by 21 publications

(9 citation statements)

References 1 publication

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“…techniques, planning of surgical corridors and navigation (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48). In these systems, preoperative planning is performed by neurosurgeons by defining the entry and the target points, thus forming a trajectory for the surgical instrument.…”

Section: Web-enabled Casmilmentioning

confidence: 99%

CASMIL: a comprehensive software/toolkit for image-guided neurosurgeries

Kaur

Tan

Alam

et al. 2006

Int. J. Med. Robotics Comput. Assist. Surg.

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Section: Web-enabled Casmilmentioning

confidence: 99%

CASMIL: a comprehensive software/toolkit for image-guided neurosurgeries

Kaur

Tan

Alam

et al. 2006

Int. J. Med. Robotics Comput. Assist. Surg.

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“…One of the research group's major concentrations is the development of prototype systems in the image-guided surgery domain. The C-PLAD approach was used to develop a component framework to support rapid application development of these prototype systems [5] [6]. Image-guided surgery is a rapidly developing field, since these procedures mean substantially less trauma for the patient.…”

Section: Image-guided Surgery: a C-plad Experience Reportmentioning

confidence: 99%

Use case-driven component specification

Blake

Cleary

Ranjan

et al. 2005

Proceedings of the 2005 ACM Symposium on Applied Computing

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Modular and flexible software components can be useful for reuse across a class of domain-specific applications or product lines. By varying the composition of components suited to a particular product line, an assortment of applications can be developed to support differing operational needs. A top-down approach to the design components for a specific application may be effective, however a more evolutionary approach is needed to support the specification of components suited for a class of applications. In addition, such evolutionary approaches require support for the knowledge transfer that must occur from domain experts, who are not software experts, to skilled software engineers. By combining concepts from Software Product Line Development (SPLD) and other evolutionary design techniques, a new, use case-driven approach has been created called Component-Based Product Line Analysis and Design (C-PLAD). This approach was used to develop components in the domain of image-guided surgery applications.

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“…We set out to leverage these platforms to develop an open source fused CT/US system by interfacing a clinical US scanner and generic clinical CT scanner, and to demonstrate the utility of such a fused system by characterizing tissues relevant to ultrasound therapy (soft tissue, bone, and fat) in a mouse breast cancer tumor model [17], [19], [20].…”

Section: Introductionmentioning

confidence: 99%

An Open Environment CT-US Fusion for Tissue Segmentation during Interventional Guidance

et al. 2011

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Therapeutic ultrasound (US) can be noninvasively focused to activate drugs, ablate tumors and deliver drugs beyond the blood brain barrier. However, well-controlled guidance of US therapy requires fusion with a navigational modality, such as magnetic resonance imaging (MRI) or X-ray computed tomography (CT). Here, we developed and validated tissue characterization using a fusion between US and CT. The performance of the CT/US fusion was quantified by the calibration error, target registration error and fiducial registration error. Met-1 tumors in the fat pads of 12 female FVB mice provided a model of developing breast cancer with which to evaluate CT-based tissue segmentation. Hounsfield units (HU) within the tumor and surrounding fat pad were quantified, validated with histology and segmented for parametric analysis (fat: −300 to 0 HU, protein-rich: 1 to 300 HU, and bone: HU>300). Our open source CT/US fusion system differentiated soft tissue, bone and fat with a spatial accuracy of ∼1 mm. Region of interest (ROI) analysis of the tumor and surrounding fat pad using a 1 mm2 ROI resulted in mean HU of 68±44 within the tumor and −97±52 within the fat pad adjacent to the tumor (p<0.005). The tumor area measured by CT and histology was correlated (r2 = 0.92), while the area designated as fat decreased with increasing tumor size (r2 = 0.51). Analysis of CT and histology images of the tumor and surrounding fat pad revealed an average percentage of fat of 65.3% vs. 75.2%, 36.5% vs. 48.4%, and 31.6% vs. 38.5% for tumors <75 mm3, 75–150 mm3 and >150 mm3, respectively. Further, CT mapped bone-soft tissue interfaces near the acoustic beam during real-time imaging. Combined CT/US is a feasible method for guiding interventions by tracking the acoustic focus within a pre-acquired CT image volume and characterizing tissues proximal to and surrounding the acoustic focus.

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IGSTK: a software toolkit for image-guided surgery applications

Cited by 21 publications

References 1 publication

CASMIL: a comprehensive software/toolkit for image-guided neurosurgeries

CASMIL: a comprehensive software/toolkit for image-guided neurosurgeries

Use case-driven component specification

An Open Environment CT-US Fusion for Tissue Segmentation during Interventional Guidance

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