IgM predominance in autoimmune disease: Genetics and gender

Duarte-Rey, Carolina; Bogdanos, Dimitrios P.; Leung, Patrick S.C.; Anaya, Juan Manuel; Gershwin, M. Eric

doi:10.1016/j.autrev.2011.12.001

Cited by 47 publications

(31 citation statements)

References 108 publications

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“…Additional observations include the increase of galactosylation and sialylation per galactose of diantennary fucosylated (A2F) species in general, which is notably different from the behavior of IgG. A contributor to this observation could be the level of IgM, an abundant immunoglobulin shown to increase with many autoimmune and inflammatory conditions and which carries the required highly galactosylated and sialylated A2F species (79,80).…”

Section: Discussionmentioning

confidence: 99%

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Reiding

Ruhaak

et al. 2017

Molecular & Cellular Proteomics

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Glycosylation is an abundant co-and post-translational protein modification of importance to protein processing and activity. Although not template-defined, glycosylation does reflect the biological state of an organism and is a high-potential biomarker for disease and patient stratification. However, to interpret a complex but informative sample like the total plasma N-glycome, it is important to establish its baseline association with plasma protein levels and systemic processes. Thus far, large-scale studies (n >200) of the total plasma N-glycome have been performed with methods of chromatographic and electrophoretic separation, which, although being informative, are limited in resolving the structural complexity of plasma N-glycans. MS has the opportunity to contribute additional information on, among others, antennarity, sialylation, and the identity of high-mannose type species.Here, we have used matrix-assisted laser desorption/ ionization ( Glycosylation is a ubiquitous co-and post-translational protein modification of functional relevance to the processing and activity of the conjugate. Examples include quality control during protein folding, regulation of circulatory half-life, and modulation of receptor interactions by either providing the recognition motif or by affecting protein conformation (1-7). Consequentially, glycosylation has been associated with a multitude of diseases and states thereof, among which the progression and metastasis of cancer and the remission of rheumatoid arthritis (8 -11). Because the process of glycosylation is not template-defined, glycosylation integrates a large series of cellular conditions such as glycosidase/glycosyltransferase abundance and activity, endoplasmic reticulum From the ‡Center

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Section: Discussionmentioning

confidence: 99%

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Reiding

Ruhaak

et al. 2017

Molecular & Cellular Proteomics

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“…The role of IgG antibodies in autoimmune neuropsychiatric syndromes has been investigated for some time, and IgG and IgM antibodies are associated with a number of autoimmune diseases of other organ systems (40,41). Steiner et al (24) have described both IgM and IgA antibodies to NMDAR in their cohort of schizophrenia patients.…”

Section: Immune-mediated Mechanisms In Childhood Psychosismentioning

confidence: 99%

“…This hypothesis is supported by our detection of IgM autoantibodies only in two patients who were also seropositive for IgG antibodies. The role of IgA antibodies is less clear, and while IgA antibodies have been associated with (41,42), future work is needed to further characterize the prevalence and role of IgA autoantibodies in neuropsychiatric disease.…”

Section: Immune-mediated Mechanisms In Childhood Psychosismentioning

confidence: 99%

Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children

Pathmanandavel

Starling

Merheb

et al. 2015

Biological Psychiatry

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“…In 2003, IgM antibodies were again found in seronegative patients, but not in the MuSK-MG fraction (19). Normally, these IgM autoantibodies are not found during established disease (20). However, this study confirms that IgM may play an important role in the pathology of MuSK-MG.…”

Section: Musk-mg Patients In Vitromentioning

confidence: 56%

Myasthenia gravis: a pathologic approach

Hounjet¹

2016

MARBLE

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Our immune system protects us from all kinds of pathogens our body faces every day.However, the immune system can also initiate an immune response against our own proteins. This is called autoimmunity. Myasthenia gravis (MG) is a rare autoimmune disease in which patients show severe muscle weakness, due to antibody production against proteins of the neuromuscular junction, which is the connection between nerve and muscle. At this moment, three different forms of myasthenia gravis are identified.Muscle-specific tyrosine kinase (MuSK)-MG is a form of MG in which patients produce antibodies, predominantly immunoglobulin (Ig)G4, against MuSK. This paper is a summary of a B cell immortalization project, in which antibodies produced by MuSK-MG patients are investigated. The aim of this study was to sequence and generate antibodies produced by these patients in vitro to learn more about the pathological mechanism of MuSK-MG. Blood-derived B cells of MuSK-MG patients were immortalized by the Epstein Bar Virusand stimulated to grow and produce antibodies in culture. Genes of these antibodies were amplified and analyzed. These amplification products were cloned in vectors and will be transfected in a human embryonic kidney (HEK)-cell line. This study showed that the B cell immortalization method worked and that MuSK-MG patients predominantly produce IgM antibodies against MuSK. This is very striking as literature states that these patients predominantly produce IgG4 against MuSK. It is suggested that this high production of IgM is due to the absence of the heavy chain isotype switch from IgM to IgG. Moreover, as the pathologic mechanism of MuSK-MG is still unknown, IgM may play an important pathological role.

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IgM predominance in autoimmune disease: Genetics and gender

Cited by 47 publications

References 108 publications

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health

Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children

Myasthenia gravis: a pathologic approach

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