IgM plasma cell myeloma with amyloidosis presenting as mammary microcalcifications

Fernández-Aguilar, Sergio; Sourtzis, Stauroula; Chaikh, Ali

doi:10.1111/j.1600-0463.2008.00943.x

Cited by 3 publications

(1 citation statement)

References 14 publications

(16 reference statements)

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“…The breast deposits are often identified during screening for breast malignancies due to presence of breast nodules and can be bilateral. (12) Pulmonary amyloidosis is the most challenging of the manifestations as there is significant overall with lymphoid interstitial pneumonitis (LIP). Patients may present with single or multiple lung nodules presenting as hemoptysis or progressive cough and shortness of breath.…”

Section: Sjogren's Syndrome Related Al Amyloidosismentioning

confidence: 99%

Systemic Amyloidosis due to Low-Grade Lymphoma

Wechalekar

Chakraborty

Lentzsch

2020

Hematology/Oncology Clinics of North America

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Section: Sjogren's Syndrome Related Al Amyloidosismentioning

confidence: 99%

Systemic Amyloidosis due to Low-Grade Lymphoma

Wechalekar

Chakraborty

Lentzsch

2020

Hematology/Oncology Clinics of North America

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Amyloid tumor of the breast

et al. 2019

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Background Amyloid tumor of the breast is a rare disease, which was first reported in 1973. To date, only six cases have been reported in Japan. Case presentation A 45-year-old woman who had a medical history of Sjogren’s syndrome presented with a lump of 3 cm in diameter on the outer side of the right breast. Mammography showed no abnormality. Ultrasonography showed a well-defined and rough hypoechoic mass of 32 mm in diameter at the site of the lump. With suspicion of breast cancer, an ultrasound-guided vacuum-assisted breast biopsy was performed. For pathological diagnosis, hematoxylin and eosin staining showed deposits of nonstructural substances in the interstitium. The specimen stained red with Congo red staining and showed green birefringence under a polarizing microscope. Thus, the mass was diagnosed as an amyloid tumor. Since the patient had Sjogren’s syndrome, it was considered a breast finding of autoimmune disease. We considered further therapy to be unnecessary, and annual follow-up was recommended. Conclusions We diagnosed the mass as an amyloid tumor by an ultrasound-guided vacuum-assisted breast biopsy without resection. The patient had no systemic symptoms suspected systemic amyloidosis, and we diagnosed localized amyloidosis. An amyloid tumor of the breast may show findings suggestive of breast cancer. Pathological diagnosis before surgery is important to avoid excessive invasion. If deposits of nonstructural substances are observed by hematoxylin and eosin staining, Congo red staining should be added.

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Morphologic Mimics of Invasive Lobular Carcinoma

Ishikawa

Pinsky²,

Smith³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Invasive lobular carcinoma of the breast is a relatively common diagnosis. However, other carcinomatous as well as noncarcinomatous neoplasms, either primary or metastatic to the breast, may mimic invasive lobular carcinoma. As treatment may differ, establishing the correct diagnosis is paramount to providing the appropriate care for these patients. This review outlines important mimics of invasive lobular carcinoma and the key clinicopathologic and immunohistochemical features as well as additional studies helpful in establishing their diagnoses.

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IgM plasma cell myeloma with amyloidosis presenting as mammary microcalcifications

Cited by 3 publications

References 14 publications

Systemic Amyloidosis due to Low-Grade Lymphoma

Systemic Amyloidosis due to Low-Grade Lymphoma

Amyloid tumor of the breast

Morphologic Mimics of Invasive Lobular Carcinoma

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