2002
DOI: 10.1001/archderm.138.10.1385
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IgM-Mediated Epidermolysis Bullosa Acquisita

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Cited by 23 publications
(12 citation statements)
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“…Routine DIF microscopy of perilesional skin or MM shows (i) linear immune deposits along the BMZ of the DEJ or CEJ, and (ii) no labelling of dermal blood vessels. The profile of immune deposits includes IgG and C3 but occasionally IgA or IgM (Table S3, case report 5; see Supporting Information) . Routine IIF microscopy on monkey, rat or rabbit oesophagus or human skin can detect anti‐BMZ autoAbs, but it is often at a low titre.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Routine DIF microscopy of perilesional skin or MM shows (i) linear immune deposits along the BMZ of the DEJ or CEJ, and (ii) no labelling of dermal blood vessels. The profile of immune deposits includes IgG and C3 but occasionally IgA or IgM (Table S3, case report 5; see Supporting Information) . Routine IIF microscopy on monkey, rat or rabbit oesophagus or human skin can detect anti‐BMZ autoAbs, but it is often at a low titre.…”
Section: Resultsmentioning
confidence: 99%
“…The profile of immune deposits includes IgG and C3 but occasionally IgA or IgM (Table S3, case report 5; see Supporting Information). [41][42][43] Routine IIF microscopy on monkey, rat or rabbit oesophagus or human skin can detect anti-BMZ autoAbs, but it is often at a low titre.…”
Section: Laboratory Testing For Epidermolysis Bullosa Acquisitamentioning
confidence: 99%
“…Using DIF, we found IgG deposits at the BMZ in all 12 patients, as well as C3 (11 ⁄ 12), IgA (6 ⁄ 12) and IgM (4 ⁄ 12). Patients with exclusive IgA and even IgM deposition in EBA have been described, 15,16 but the role of immunoglobulin diversity in determining EBA phenotype remains unravelled. 4,15,16 IIF was positive for IgG in half of our patients.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with exclusive IgA and even IgM deposition in EBA have been described, 15,16 but the role of immunoglobulin diversity in determining EBA phenotype remains unravelled. 4,15,16 IIF was positive for IgG in half of our patients. The use of salt-split skin specimens improved IIF sensitivity, detecting a predominance of dermal IgG deposits, a result that agrees with previous studies.…”
Section: Discussionmentioning
confidence: 99%
“…Different patterns of IgM staining have been described in the medical literature: linear, granular, linear granular, diffuse linear and band‐like granular. The granular pattern is found more frequently in lupus erythematosus but is also encountered in other conditions (Table ).…”
Section: Discussionmentioning
confidence: 96%