IgM-Mediated Epidermolysis Bullosa Acquisita

Suchniak, J.M.; Díaz, Luis A.; Lin, Mong Shang; Fairley, Janet A.

doi:10.1001/archderm.138.10.1385

Cited by 23 publications

(12 citation statements)

References 5 publications

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“…Routine DIF microscopy of perilesional skin or MM shows (i) linear immune deposits along the BMZ of the DEJ or CEJ, and (ii) no labelling of dermal blood vessels. The profile of immune deposits includes IgG and C3 but occasionally IgA or IgM (Table S3, case report 5; see Supporting Information) . Routine IIF microscopy on monkey, rat or rabbit oesophagus or human skin can detect anti‐BMZ autoAbs, but it is often at a low titre.…”

Section: Resultsmentioning

confidence: 99%

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International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita

et al. 2018

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Section: Resultsmentioning

confidence: 99%

“…The profile of immune deposits includes IgG and C3 but occasionally IgA or IgM (Table S3, case report 5; see Supporting Information). [41][42][43] Routine IIF microscopy on monkey, rat or rabbit oesophagus or human skin can detect anti-BMZ autoAbs, but it is often at a low titre.…”

Section: Laboratory Testing For Epidermolysis Bullosa Acquisitamentioning

confidence: 99%

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita

et al. 2018

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“…Using DIF, we found IgG deposits at the BMZ in all 12 patients, as well as C3 (11 ⁄ 12), IgA (6 ⁄ 12) and IgM (4 ⁄ 12). Patients with exclusive IgA and even IgM deposition in EBA have been described, 15,16 but the role of immunoglobulin diversity in determining EBA phenotype remains unravelled. 4,15,16 IIF was positive for IgG in half of our patients.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with exclusive IgA and even IgM deposition in EBA have been described, 15,16 but the role of immunoglobulin diversity in determining EBA phenotype remains unravelled. 4,15,16 IIF was positive for IgG in half of our patients. The use of salt-split skin specimens improved IIF sensitivity, detecting a predominance of dermal IgG deposits, a result that agrees with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Clinical and immunopathological evaluation of epidermolysis bullosa acquisita

Delgado

Aoki

Santi

et al. 2011

Clinical and Experimental Dermatology

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“…Different patterns of IgM staining have been described in the medical literature: linear, granular, linear granular, diffuse linear and band‐like granular. The granular pattern is found more frequently in lupus erythematosus but is also encountered in other conditions (Table ).…”

Section: Discussionmentioning

confidence: 96%

Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo–epidermal junction

et al. 2015

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Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is to present a case of diffuse bullous mastocytosis with detection of IgM deposits at dermo-epidermal junction using direct immunofluorescence (DIF) microscopy. The diagnosis of diffuse bullous mastocytosis is a challenge, and DIF microscopy is necessary in order to exclude an autoimmune bullous disorder. However, IgM deposits at dermo-epidermal junction can be nonspecific, being found in a variety of skin disorders. A 6-month-old girl presented with bullous lesions and erosions on the scalp and the trunk. During hospitalization, further bullous lesions appeared, along with generalized erythrodermia. Skin biopsy revealed aspects of urticaria pigmentosa. Taking into account the clinical findings, the case was enclosed as bullous mastocytosis. Treatment included the avoidance of trigger factors, and administration of antihistamines along with a short-term course of systemic steroids. The evolution was favorable, with remission of the existing lesions and without occurrence of new ones.

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IgM-Mediated Epidermolysis Bullosa Acquisita

Cited by 23 publications

References 5 publications

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita

International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita

Clinical and immunopathological evaluation of epidermolysis bullosa acquisita

Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo–epidermal junction

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