IgM and IgG antibodies against SARS-CoV-2 in neonates born to mothers with COVID-19

Semeshkin, A.A.; Вечорко, В.И.; Силаев, Б.В.; Левчук, Н. Н.; Поликарпова, С. В.; Ov, Averkov

doi:10.24075/brsmu.2020.036

Cited by 2 publications

(3 citation statements)

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“…In total, the studies reported findings from 325 women whose pregnancy outcome was known following SARS-CoV-2 infection, seven of which were twin pregnancies [ 25 , [31] , [32] , [33] , [34] , [35] ], six pregnancies were terminated (one for maternal health reasons [ 18 ], one for personal reasons [ 19 ], three for “personal choice” [ 21 ] and one where the reason was unclear [ 17 ]). Of the remaining pregnancies, 83 births (58%) were by Caesarean section and no information was provided in 16 cases.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 167 infants were born after 37 weeks' gestation, and 58 were born preterm (including four sets of twins), with the majority being born after 30 weeks' gestation. Seven infants were born in the “third trimester” (not defined by studies) and the exact gestation of 95 infants was unclear [ 17 , 25 , 35 ], with one study providing median gestational ages and the interquartile range which included four multiple-pregnancies [ 25 ]. There were six terminations of pregnancy including one at 22 weeks' gestation [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…Conversely, one infant born at 38 weeks' gestation tested negative for both IgM and IgG antibodies, with the mother testing positive five weeks before delivery [ 39 ] and one infant tested negative for both IgM and IgG 10 days after birth [ 42 ]. Semeshkin et al reported the IgM and IgG results of 21 neonates, tested 1 or 2 days after birth; one case had raised levels of both IgM and IgG and only IgG was raised in 14 neonates [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

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A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection

et al. 2020

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, was first identified after a cluster of cases in Wuhan, China in December 2019. Whether vertical transmission or placental pathology might occur following maternal infection during pregnancy remains unknown. This review aimed to summarise all studies that examined the placenta or neonates following infection with SARS-CoV-2, or closely related highly pathogenic coronavirus (SARS-CoV-1, or the Middle East respiratory syndrome coronavirus (MERS-CoV)). Structured literature searches found 50 studies that met the inclusion criteria. Twenty studies reported placental histopathology findings in third trimester placentas following maternal SARS-CoV-2 infection. Using the Amsterdam Consensus criteria to categorise the histopathology results, evidence of both fetal vascular malperfusion (35.3% of cases; 95% Confidence Interval (CI) 27.7–43.0%) and maternal vascular malperfusion (46% of cases; 95% CI 38.0–54.0%) were reported, along with evidence of inflammation in the placentas (villitis 8.7% cases, intervillositis 5.3% of cases, chorioamnionitis 6% of cases). The placental pathologies observed in SARS-CoV-2 were consistent with findings following maternal SARS-CoV-1 infection. Of those tested, a minority of neonates (2%) and placental samples tested positive for SARS-CoV-2 infection (21%). Limited conclusions can be drawn about the effect of maternal SARS-CoV-2 infection on placental pathology as most lack control groups and the majority of reports followed third trimester infection. Collaboration to maximise the number of samples examined will increase the reliability and generalisability of findings. A better understanding of the association between maternal SARS-CoV-2 infection and placental pathology will inform maternity care during the coronavirus pandemic.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection

et al. 2020

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Laboratory Effects of COVID-19 Infection in Pregnant Women and Their Newborns: A Systematic Review and Meta-Analysis

Zhang

Chu

Pei

et al. 2021

Front. Glob. Womens Health

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Amidst the COVID-19 pandemic, there is a need for further research on its manifestation in pregnant women, since they are particularly prone to respiratory pathogens, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), due to physiological changes during pregnancy. Its effects on infants born to mothers with COVID-19 are also not well-studied, and more evidence is needed on vertical transmission of the disease from mother to infant and on the transmission of IgG/IgM antibodies between mother and infant. We aim to systematically review and evaluate the effects of COVID-19 among SARS-CoV-2-positive pregnant women in late pregnancy and neonates with SARS-CoV-2-positive pregnant mothers using blood assays to find indicators of maternal and neonatal complications. We searched for original published articles in Google Scholar, Medline (PubMed), and Embase databases to identify articles in the English language from December 2019 to July 20, 2020. Duplicate entries were searched by their titles, authors, date of publication, and Digital Object Identifier. The selected studies were included based on patient pregnancy on admission, pregnant mothers with laboratory-confirmed COVID-19 virus, maternal/neonatal complications, and blood test results. We excluded duplicate studies, articles where full text was not available, other languages than English, opinions, and perspectives. The meta-analysis using the Generalized Linear Mixed model was conducted using the “meta” and “metaprop” packages in R code. Of the 1,642 studies assessed for eligibility, 29 studies (375 mothers and neonates) were included. Preterm birth rate was 34.2%, and cesarean section rate was 82.7%. Maternal laboratory findings found elevated neutrophils (71.4%; 95% CI: 38.5–90.9), elevated CRP (67.7%; 95%: 50.6–81.1), and low hemoglobin (57.3%; 95% CI: 26.0–87.8). We found platelet count, lactate dehydrogenase, and procalcitonin to be less strongly correlated with preterm birth than between high neutrophil counts (P = 0.0007), low hemoglobin (P = 0.0188), and risk of preterm birth. There is little evidence for vertical transmission. Elevated procalcitonin levels (23.2%; 95% CI: 8.4–49.8) are observed in infants born to mothers with COVID-19, which could indicate risk for neonatal sepsis. These infants may gain passive immunity to COVID-19 through antibody transfer via placenta. These results can guide current obstetrical care during the current SARS-CoV-2 pandemic.

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IgM and IgG antibodies against SARS-CoV-2 in neonates born to mothers with COVID-19

Cited by 2 publications

References 7 publications

A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection

A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection

Laboratory Effects of COVID-19 Infection in Pregnant Women and Their Newborns: A Systematic Review and Meta-Analysis

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