IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway

Chu, Jing; Li, Yutong; Deng, Zhihai; Zhang, Zhenlin; Xie, Qun; Zhang, Heyuan; Zhong, Wen-Fang; Pan, Bin

doi:10.1155/2019/7201562

Cited by 37 publications

(22 citation statements)

References 31 publications

(39 reference statements)

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“…Previous studies have indicated that IGHG1 demonstrated promotive effects on tumor expansion in murine pancreatic cancer models [ 13 ]. Moreover, several studies on ovarian cancer, prostate cancer also indicated that IGHG1 promoted tumor migration and metastasis via modulating EMT [ 14 ] or MEK/ERK/c-Myc pathway [ 15 ]. Our study provided consistent results that IGHG1 significantly promoted proliferative and migrative capabilities of gastric cancer cells, which could be potential therapeutic target in future treatment development.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it was reported that IGHG1 could induce EMT in gastric cancer cells by regulating TGF-β/SMAD3 signaling pathway [ 16 ], which is in line with our study. Meanwhile, inhibition of IGHG1 restrained the tumor growth in nude mice and inactivated MEK/ERK/c-Myc pathway [ 15 ]. Suppression of IGHG1 leaded to growth inhibition and apoptosis induction in human prostate cancer cell [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway

Chen

Yang

et al. 2021

Cancer Cell Int

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Background Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin serve as important regulators of tumor cellular malignancy. Therefore, understanding detailed molecular mechanism and identifying druggable target will be of great potentials in future therapeutic development. Methods Surgical tissues and gastric cancer cell lines were retrieved to evaluate IGHG1 expression for patients with or without lymph node/distal organ metastasis. Functional assays including CCK8 assay, Edu assay, sphere formation assay and transwell assay, wound healing assay, etc. were subsequently performed to evaluate the impact of IGHG1/-catenin axis on tumor cell proliferation, migration and chemo-resistance. Results Gastric cancer tissues and tumor cell lines demonstrated significantly higher level of IGHG1. Functional study further demonstrated that IGHG1 promoted proliferative and migration as well as chemo-resistance of gastric cancer tumor cells. Further experiments indicated that IGHG1 activated AKT/GSK-3/-Catenin axis, which played crucial role in regulation of proliferative and chemo-resistance of gastric cancer cells. Conclusion This study provided novel evidences that IGHG1 acted as oncogene by promotion of gastric cancer cellular proliferation, migration and chemo-resistance. Our research further suggested that IGHG1/AKT/GSK-3β/β-Catenin axis acted as novel pathway which regulated gastric cancer cellular malignant behavior. Our research might inspire future therapy development to promote overall prognosis of gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway

Chen

Yang

et al. 2021

Cancer Cell Int

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“…The protumorigenic roles of secreted cancer-derived IgG can be blocked by its specific monoclonal antibody RP215. In another study, the MEK/ERK/c-Myc pathway was demonstrated to be another downstream pathway of cancer-derived IgG regulating cell growth and the cell cycle ( 83 ). Moreover, Igκ and Igλ have been shown to be responsible for maintaining high expression of the antiapoptotic molecule Bcl-xL and thus perform roles in resisting apoptosis ( 84 ).…”

Section: Cancer-derived Ig Performs Critical Roles In Cancer Progressmentioning

confidence: 99%

Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis

et al. 2021

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Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig. Further studies have shown that cancer-derived Ig shares identical basic structures with B cell-derived Ig but exhibits several distinct characteristics, including restricted variable region sequences and aberrant glycosylation. In contrast to B cell-derived Ig, which functions as an antibody in the humoral immune response, cancer-derived Ig exerts profound protumorigenic effects via multiple mechanisms, including promoting the malignant behaviors of cancer cells, mediating tumor immune escape, inducing inflammation, and activating the aggregation of platelets. Importantly, cancer-derived Ig shows promising potential for application as a diagnostic and therapeutic target in cancer patients. In this review, we summarize progress in the research area of cancer-derived Ig and discuss the perspectives of applying this novel target for the management of cancer patients.

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“…The role of IGHG1 in CRC has never been investigated. In prostate cancer research, inhibition of IGHG1 can suppress cell growth and induce cell cycle arrest and ultimate apoptosis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

The aging-related risk signature in colorectal cancer

Yue

Chen

Zhu

et al. 2021

Aging

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Background: Colorectal cancer (CRC) is the third most common cancer worldwide. The opening of the TCGA and GEO databases has promoted the progress of CRC prognostic assessment, while the aging-related risk signature has never been mentioned. Methods: R software packages, GSEA software, Venn diagram, Metascape, STRING, Cytoscape, cBioPortal, TIMER and GeneMANIA website were used in this study. Results: Aging-related gene sets, GO_AGING, GO_CELL_AGING and GO_CELLULAR_SENESCENCE, were activated significantly in CRC tissues. We constructed an aging-related risk signature using LASSO COX regression in training group TCGA and validated in testing group GSE39582. The risk score was significantly associated with the overall survival of CRC patients, whose stability was clarified by stratified survival analysis and accuracy was demonstrated using the ROC curve. The risk score was significantly increased in the advanced stage, T3-4, N1-3 and M1 and positively correlated with the richness of immune cell infiltration in the tumor microenvironment. We further investigated the molecular characteristics of 15 hub genes at the DNA and protein levels and performed GSEA between high- and low-risk groups. Conclusions: The aging-related signature is a reliable prognostic analysis model and can predict the severity and immune cell infiltration of CRC patients.

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IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway

Cited by 37 publications

References 31 publications

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway

Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis

The aging-related risk signature in colorectal cancer

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