IgG4-related kidney disease: experience from a Mexican cohort

Martín‐Nares, Eduardo; Hernández-Molina, Gabriela; Rodríguez-Ramírez, Sonia; Rivera-Fuentes, Lemuel; Niño-Cruz, José Antonio; Núñez-Abreu, Alicia; Espinosa-González, Ricardo; Uribe‐Uribe, Norma

doi:10.1007/s10067-020-05135-y

Cited by 18 publications

(39 citation statements)

References 22 publications

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“…There is a great variability of disease manifestations for IgG4-RD, and the identification of different IgG4-RD subgroups is crucial, as a consequence of significant disparities in the characteristics of IgG4-RD regarding different organs 6 , 15 . In our study, the frequency of kidney involvement in IgG4-RD patients was 11.8%, which is lower than that of Japan (23.7%) and Mexico (24.6%) 6 , 16 , but similar to that of UK study 11 . The heterogeneity of IgG4-RKD+ definition and ethnicity in various studies may explain for this diversity.…”

Section: Discussioncontrasting

confidence: 44%

“…In previously reported studies, kidney function in IgG4-RKD+ patients varies from normal to renal failure, and the development of renal dysfunction also varies from relatively acute to slowly progressive 13 , 14 , 16 , 17 , 21 . In our cohort, the renal function was impaired manifesting as the reduced eGFR, elevated blood urea nitrogen, elevated serum creatine and abnormal specific renal tubular function test.…”

Section: Discussionmentioning

confidence: 91%

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Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Zeng

Gao

Zhang

et al. 2021

Sci Rep

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We aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD−) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+. We retrospectively analyzed the medical records of 470 IgG4-related disease (IgG4-RD) patients at Peking University People’s Hospital from January 2004 to January 2020. The demographic, clinical, laboratory, radiological and pathological characteristics between IgG4-RKD+ and IgG4-RKD− were compared. Twenty IgG4-RD patients who had definite etiology of renal impairment including diabetes, hypertension and etc. were excluded. Among the remained 450 IgG4-RD patients, 53 were diagnosed with IgG4-RKD+ . IgG4-RKD+ patients had older age at onset and at diagnosis. Male to female ratio of IgG4-RKD+ patients is significantly higher. In the IgG4-RKD+ group, the most commonly involved organs were salivary gland, lymph nodes and pancreas. It was found that renal function was impaired in approximately 40% of IgG4-RKD+ patients. The most common imaging finding is multiple, often bilateral, hypodense lesions. Male sex, more than three organs involved, and low serum C3 level were risk factors for IgG4-RKD+ in IgG4-RD patients. These findings indicate potential differences in pathogenesis of these two phenotypes.

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Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 91%

Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Zeng

Gao

Zhang

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In previously reported studies, kidney function in IgG4-RKD+ patients varies from normal to renal failure, and the development of renal dysfunction also varies from relatively acute to slowly progressive [13,16,18,20,21]. In our cohort, the renal function was impaired manifesting as the reduced eGFR, elevated blood urea nitrogen, elevated serum creatine and abnormal speci c renal tubular function test.…”

Section: Discussionmentioning

confidence: 54%

“…There is a great variability of disease manifestations for IgG4-RD, and the identi cation of different IgG4-RD subgroups is crucial, as a consequence of signi cant disparities in the characteristics of IgG4-RD regarding different organs [6,14]. In our study, the frequency of kidney involvement in IgG4-RD patients was 14.7%, which is lower than that of Japan (23.7%) and Mexico (24.6%) [6,15], but similar to that of UK study [11]. The heterogeneity of IgG4-RKD+ de nition and ethnicity in various studies may explain for this diversity.…”

Section: Discussionmentioning

confidence: 55%

Disparities between IgG4-related disease with and without kidney involvement: a case-control study based on 450 patients

Zeng¹,

Zhang²,

A³

et al. 2020

Preprint

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Background We aimed to compare the demographic, clinical and laboratory characteristics between IgG4-related kidney disease (IgG4-RKD+) and extrarenal IgG4-related disease (IgG4-RKD-) in a large Chinese cohort, as well as describing the radiological and pathological features of IgG4-RKD+.Methods We retrospectively analyzed the medical records of 450 IgG4-RD patients at Peking University People’s Hospital from January 2004 to January 2020.Results Among the 450 IgG4-RD patients, 66 were diagnosed with IgG4-RKD+. Compared with IgG4-RKD- patients, IgG4-RKD+ patients had older age at onset and at diagnosis (59 vs 54, P=0.007; 61 vs 56, P=0.002, respectively). Male to female ratio of IgG4-RKD+ patients is significantly higher (2.5:1 vs 1.2:1, P=0.015). In the IgG4-RKD+ group, the most commonly involved organs were salivary gland (54.6%), lymph nodes (47.0%) and pancreas (40.9%). More than three organs involved (OR=6.212), retroperitoneal fibrosis involvement (RPF) (OR=12.460) and low serum C3 level (OR=0.202) were risk factors for the kidney disease in IgG4-RD patients. It was found that renal function was impaired in more than 50% of IgG4-RKD+ patients. The most common imaging finding is multiple, often bilateral, hypodense lesions, followed by ureteric obstruction and hydronephrosis related to RPF, and thickening of the renal pelvic wall. Conclusions Involvement of three or more organs, retroperitoneal fibrosis and low serum C3 level were risk factors for the kidney disease in IgG4-RD patients. These findings indicate potential differences in pathogenesis of these two phenotypes.

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“…However, only few studies have investigated the differences in clinical characteristics in patients with or without IgG4-RKD. 11,21 Thus, we compared the clinical features and outcomes between these patients. Results showed that patients with IgG4-RKD were older and had a higher incidence of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of Immunoglobulin G4-related Disease

Lee

Yang

2021

Preprint

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Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized disease, and a few epidemiologic studies about this disorder have been published. This research aimed to describe the clinical, laboratory, and histopathological features and outcomes of IgG4-RD. Ninety-four patients who satisfied the comprehensive diagnostic criteria on IgG4-RD were included in this study. Fifty-eight (61.7%) were men. The mean age was 54.8 years, and the median follow-up duration was 32.9 months. The clinical feature between single and multiple organ involvement and with or without kidney involvement groups were evaluated based on symptoms and laboratory findings. The clinical outcome was assessed according to treatment strategies and response. Of 94 patients, 56 (59.6%) had multiple organs involvement. Patients with multiple organ involvement had higher serum IgG and IgG4 levels than those with single organ involvement. Those with IgG4-related kidney disease (IgG4-RKD) had worse renal function, and the incidence of peripheral blood eosinophilia and hypocomplementemia was higher in patients with renal involvement than in those without. Glucocorticoids-based therapy was most commonly used. (79.8%). Thirty-nine (41.5%) achieved complete remission. Eighteen (19.1%) relapsed after response to treatment. IgG4-RD had different clinical features and outcomes. The number of organ involvement and kidney involvement were not associated with clinical outcomes.

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IgG4-related kidney disease: experience from a Mexican cohort

Cited by 18 publications

References 22 publications

Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case–control study based on 450 patients

Disparities between IgG4-related disease with and without kidney involvement: a case-control study based on 450 patients

Clinical Features and Outcomes of Immunoglobulin G4-related Disease

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