IgG4-related disease: what do we know after 20 years

Sokol, E.

doi:10.26442/00403660.2020.05.000632

Cited by 4 publications

(1 citation statement)

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“…Проявления IgG4-СЗ многообразны, описано поражение самых разных органов и систем (рис. 2) [7][8][9], к наиболее типичным относят поражение глаз (псевдотумор орбиты, дакриоаденит), сиалоаденит, ретроперитонеальный фиброз, аутоиммунный панкреатит 1-го типа. Могут вовлекаться другие ткани и органы, такие как легкие, почки, аорта, ВДП, щитовидная железа, оболочки мозга, сердце и кожа.…”

Section: Kokosadzeunclassified

Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the phenomenon of IgG4 overproduction. Literature review and own observations

Бекетова¹,

Kokosadze

2020

Naučno-praktičeskaâ revmatologiâ

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Systemic vasculitis (SV) associated with anti-neutrophilic cytoplasmic antibodies is a multifactorial process characterized by the variability of the epitope specificity of anti-neutrophilic cytoplasmic antibodies and the diversity of clinical phenotypes of the disease. In recent years, there has been an increasing interest in the combination of AAV and the phenomenon of IgG4 hyperproduction, which varies widely within AAV, from anti-neutrophilic cytoplasmic antibodies products of IgG4 subclass of undetermined significance, the presence of IgG4 positive plasma cells in the foci of immunoinflammatory lesions in patients with a definite diagnosis of AAV, to the typical clinical manifestations of an IgG4-related disease (IgG4-RD). We introduce own clinical case and analyze the combined data of the literature, which included 35 cases of a combination of AAV and IgG4-related pathology, indicating existing differences in the clinical manifestations of classical IgG4-RD and when combined with AAV. The currently accumulated data allows us to discuss the allocation of a specific clinical and immunological variant of AAV with IgG4 hyperproduction, characterized by a combination of clinical manifestations of AAV and clinical and / or histological signs of IgG4-related pathology. It is important to emphasize that the allocation of phenotypes of AAV in the future may be important for the personalized choice of treatment tactics for patients.

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Section: Kokosadzeunclassified

Clinical and immunological variants of ANCA-associated systemic vasculitis: a look at the phenomenon of IgG4 overproduction. Literature review and own observations

Бекетова¹,

Kokosadze

2020

Naučno-praktičeskaâ revmatologiâ

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Features of the course of diabetes mellitus in IgG4-associated disease

Panevin,

Torgashina,

Movsesyan

2023

Diabetes mellitus

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IgG4-related disease (IgG4-RD) is characterized by the appearance of tumor-like foci in one or more organs, occurring synchronously or metachronously, due to fibro-inflammatory changes with hypersecretion of immunoglobulin G subclass 4 (IgG4) in tissues and/or blood serum. Diabetes mellitus (DM) develops among 43-68% of patients with IgG4-related pancreatitis. Diabetes against the background of IgG4-RD can be caused both by damage to the endocrine part of the pancreas and the use of glucocorticosteroids, but its course is moderate, with a rare need for insulin therapy. In both cases, the use of genetically engineered biological therapy with rituximab may be accompanied by an improvement in carbohydrate metabolism. This article describes the course of diabetes and the need for hypoglycemic therapy for 1.5 years in a patient treated with IgG4-RD.

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