IgG4-related disease of the ileocecal region mimicking malignancy: A case report

Hiyoshi, Yukiharu; Oki, Eiji; Zaitsu, Yoko; Ando, Koji; Ito, Shuhei; Saeki, Hiroshi; Morita, Masaru; Yamamoto, Hidetaka; Baba, Hideo; Maehara, Yoshihiko

doi:10.1016/j.ijscr.2014.08.003

Cited by 61 publications

(19 citation statements)

References 19 publications

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“…presented a case of a patient in whom there was concern for cholangiocarcinoma and who underwent a left trisectionectomy but was ultimately diagnosed with IgG4-related disease 20 . IgG4-related disease can also be initially mistaken for lymphoma, as both diseases can present with lymph node swelling as an initial symptom 21 , 22 . Differentiating IgG4-related disease from cancer is of the utmost importance.…”

Section: Clinical Presentationmentioning

confidence: 99%

Recent advances in understanding and managing IgG4-related disease

Wolfson

Hamilos

2017

F1000Res

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IgG4-related disease was only recently discovered, so its description, management, and new discoveries related to its etiology are rapidly evolving. Because IgG4 itself is a unique antibody which is intimately related to the diagnosis of the disease, the role of plasmablasts in the pathophysiology remains an active area of discussion. Recent studies have uncovered a possible role for CD4-positive cytotoxic T lymphocytes, T follicular helper cells, and M2 macrophages. The clinical presentation is variable and can be vague, as this disease affects many organs and new presentations are continuing to be described. The diagnosis depends on clinical and histopathological assessment. The mainstay of treatment is with glucocorticoids, but rituximab has recently shown promise. Monitoring disease activity using imaging modalities (including positron emission tomography) and serum markers is imperative, as relapses are common. IgG4-related disease spans many medical disciplines but is a treatable condition with which all clinicians should be familiar.

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Section: Clinical Presentationmentioning

confidence: 99%

Recent advances in understanding and managing IgG4-related disease

Wolfson

Hamilos

2017

F1000Res

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“…This obligates a thorough study, with diagnosis and treatment of all malignant-suggestive lesions including surgical options due to benign lesions that simulate malignancy, such as inflammatory pseudotumors. In the literature, the findings in IgG4-related inflammatory pseudotumors are often multi-organic or as a single solid mass [ 7 ], as in this case report.…”

Section: Discussionmentioning

confidence: 86%

Immunoglobulin G4-related gastric pseudotumor – An impostor: Case report

Mosquera

Gómez

Herrera

et al. 2020

International Journal of Surgery Case Reports

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Highlights Gastric pseudotumors are rare entities that resemble gastric neoplasias and often unrecognized. Suggestive malignant gastric masses can in fact result IgG4-related pseudotumors. Gastric pseudotumors are often an incidental diagnosis upon histologic analysis after surgical resection. Understanding gastric pseudotumors can reduce unwarranted surgical intervention.

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“…There are 3 previously reported cases of IgG4-related disease involving the small bowel. Two presented as bowel wall thickening ( 4 10 ), and 1 as multiple pelvic masses obstructing the bowel lumens ( 3 ). Despite the few reports of IgG4-related disease involving the gastrointestinal tract, there appear to be 2 types of IgG4-related gastrointestinal disease.…”

Section: Discussionmentioning

confidence: 99%

“…Greater fat infiltration than bowel wall thickening implies that the main pathology lies in the mesentery rather than the gastrointestinal tract ( 11 ). Subserosal plasmacyte infiltration also indicates that the disease originates from the mesentery and involves the gastrointestinal tract ( 10 ). In this case, these factors may have collectively caused periappendiceal fatty strands.…”

Section: Discussionmentioning

confidence: 99%

Appendiceal Immunoglobulin G4-Related Disease Mimicking Appendiceal Tumor or Appendicitis: A Case Report

2016

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Immunoglobulin G4 (IgG4)-related disease is an autoimmune disease that forms tumorous lesions. Several cases involving various organs are reported, however, IgG4-related disease involving appendix has not been reported yet. In this report, we presented a case of IgG4-related disease of appendix, which raised a suspicion of appendiceal tumor or usual appendicitis and, therefore, led to unnecessary surgical resection. IgG4-related disease should be considered in the differential diagnosis for a mass-like swelling of the appendix, in order to avoid unnecessary surgery.

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IgG4-related disease of the ileocecal region mimicking malignancy: A case report

Cited by 61 publications

References 19 publications

Recent advances in understanding and managing IgG4-related disease

Recent advances in understanding and managing IgG4-related disease

Immunoglobulin G4-related gastric pseudotumor – An impostor: Case report

Appendiceal Immunoglobulin G4-Related Disease Mimicking Appendiceal Tumor or Appendicitis: A Case Report

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