IgG4-related Disease of the Head and Neck

Bhatti, Rahat; Stelow, Edward B.

doi:10.1097/pap.0b013e31827b619e

Cited by 53 publications

(53 citation statements)

References 79 publications

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“…Management with corticosteroids leads to decreased serum levels of IgG4 and remission of clinical and radiological symptoms. In the majority of patients, clinical results are obtained quickly, and the response to treatment depends upon the length of time of the disease and the degree of fibrosis of the affected organ [1,2,4].…”

Section: Discussionmentioning

confidence: 99%

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IgG4-related disease in the head and neck region: report of two cases and review of the literature

Gontarz¹,

Wyszyńska-Pawelec²,

Zapała³

et al. 2016

pjp

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IgG4-related disease (IgG4-RD) is a rare immune-mediated condition characterized by extensive tissue fibrosis and infiltration by immunoglobulin G4 positive plasma cells in a single organ or systemic appearance. Two cases are presented including an unusual case of a 30-year-old man with IgG4-RD appearing simultaneously in the cervical lymph nodes, ethmoid, maxillary sinuses, and upper gingiva, with spontaneous loss of teeth. According to the literature, this is the first case with loss of teeth occurring in the course of the disease. The second case is a 46-year-old man suffering from IgG4-related chronic sclerosing sialadenitis of the right submandibular gland.

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Section: Discussionmentioning

confidence: 99%

“…Clinical symptoms of IgG4-RD may mimic malignant neoplasm or infection [1,2,3]. IgG4-RD is diagnosed most commonly in the pancreas, followed by the head and neck region, particularly in the salivary glands, orbits, lymph nodes, thyroid, upper respiratory tract, and skin [1,2,4,5].…”

Section: Introductionmentioning

confidence: 99%

IgG4-related disease in the head and neck region: report of two cases and review of the literature

Gontarz¹,

Wyszyńska-Pawelec²,

Zapała³

et al. 2016

pjp

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“…The head and neck is the second most common site for involvement by IgG4RSD, after the pancreatobiliary system 5. However, involvement of the paranasal sinus is quite rare, with only six adult cases reported previously in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Unusual cause of maxillary sinus mass with proptosis

Kurien¹,

Telugu

Rupa

2015

BMJ Case Reports

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We report a case of a 21-year-old Indian man with an 8-month history of left-sided headache, maxillary sinus mass, proptosis and swelling of the left temple, whose contrast-enhanced CT scans of the paranasal sinuses showed an enhancing, destructive soft tissue mass involving the left maxillary sinus, orbit, infratemporal fossa and anterior cranial fossa, suggestive of a malignancy or chronic granulomatous disease. Histopathological examination of the sinus mass, which was debulked and partially excised via an endoscopic approach, suggested a diagnosis of immunoglobulin G4-related sclerosing disease of the maxillary sinus. Subsequent immunohistochemical staining and biochemical tests confirmed the diagnosis. We highlight the importance of considering this increasingly recognised but rare entity that can mimic a malignant lesion with its clinical and radiological features but which, unlike the latter, has a very good prognosis with appropriate treatment.

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“…Approximately seven cases of B or T-cell non-Hodgkin lymphoma have been described in the external auditory canal [27]. Besides lymphoma and leukemia, the temporal bone and middle ear can be involved by Langerhans cell histiocytosis and rarely the temporal bone may be involved by IgG4-related disease (discussed below) [29]. Leukemic infiltrates of CLL/SLL may be seen in the temporal bone with associated symptoms of facial nerve palsy, hearing loss or balance disorders due to associated involvement of VII and VIII cranial nerves respectively.…”

Section: Earsmentioning

confidence: 99%