IgG4 Related Disease of the Head and Neck

Abstract

IgG4 related disease of the head and neck region represents one of the more common manifestations of IgG4 related disease.

Eosinophilic angiocentric fibrosis : a sino-orbital masquerader

“…IgG4 RD and subsequently EAF can mimic inflammatory and neoplastic processes; therefore, clinical suspicion must remain high and necessary steps must be taken to rule out these other conditions 3. Histopathology is the hallmark for diagnosis of IgG4 RD and subsequently EAF 10.…”

“…The epidemiology of IgG4 RD is unclear, as there are few population-based studies in the literature 2. The disease is typically diagnosed incidentally through radiological findings or pathological specimens 3. IgG4 RD can affect many different organ systems and is known to mimic many inflammatory and neoplastic processes; therefore, it is important to be familiar with the wide variety of clinical presentations 3.…”

“…The disease is typically diagnosed incidentally through radiological findings or pathological specimens 3. IgG4 RD can affect many different organ systems and is known to mimic many inflammatory and neoplastic processes; therefore, it is important to be familiar with the wide variety of clinical presentations 3. Orbital and ocular adnexal involvement is a common presentation in IgG4 RD and most often involves the lacrimal gland but can also involve the extraocular muscles, soft tissue of the orbit and branches of the trigeminal nerve 3…”

Adenoid cystic carcinoma arising in association with pleomorphic adenoma in a background of chronic sclerosing sialadenitis (Küttner tumor)

“…Of note, the patient has a history of renal disease and hypothyroidism, both of which can be associated with IgG4-related disease. [8,14] Another IgG4 disease involving salivary glands is Mikulicz's syndrome [14] which is characterized by enlargement of the parotid and/or lacrimal glands and is associated with Sjö-gren's syndrome. The patient in this case did not have apparent lacrimal gland or parotid gland involvement and showed no clinical signs of Sjögren's syndrome.…”

Immunoglobulin G4 related disease: a single‐centre experience from South Australia

“…IgG4RD has the ability to affect virtually all organ systems, but most commonly involves the pancreas and biliary tree, salivary glands, periorbital tissues, kidneys, lungs, retroperitoneum and lymph nodes . Less common sites of disease activity include the central nervous system (including the meninges and pituitary gland), pericardium and the aorta .…”