IgG4-related disease involving the sclera

Ohno, Kyotaro; Sato, Yasuharu; Ohshima, Koh Ichi; Takata, Katsuyoshi; Ando, Masayuki; Al-Kader, Lamia Abd; Iwaki, Noriko; Takeuchi, Mai; Orita, Yorihisa; Yoshino, Tadashi

doi:10.3109/14397595.2013.852842

Cited by 39 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recently published review 1 described its many systemic manifestations. It is now believed that IgG4-RD may affect almost any organ in the human body, including the orbit, 2,3 sclera, 4 anterior uvea, 5 and choroid. 6 We report the first case of choroidal effusion as an ocular manifestation in a patient with IgG4-RD.…”

mentioning

confidence: 99%

Choroidal Effusion as an Ocular Manifestation of Immunoglobulin G4–related Disease

Koenigstein

Neudorfer²,

Goldenberg³

et al. 2016

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Choroidal Effusion as an Ocular Manifestation of Immunoglobulin G4–related Disease

Koenigstein

Neudorfer²,

Goldenberg³

et al. 2016

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

show abstract

“…On the contrary, only a few cases of IgG4-ROD with scleral involvement have been reported [7,8]. Ohno et al [7] reported a case of a 49-year-old patient who underwent enucleation of the eyeball with a clinical diagnosis of choroidal tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Ohno et al [7] reported a case of a 49-year-old patient who underwent enucleation of the eyeball with a clinical diagnosis of choroidal tumor. This case was first treated as scleritis, but was refractory to treatment with systemic corticosteroids and cyclosporine.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin G4-Related Ophthalmic Disease Involving the Sclera Misdiagnosed as Intraocular Tumor: Report of One Case

Gotô

Ueda

2016

Ocul Oncol Pathol

View full text Add to dashboard Cite

Aims: Immunoglobulin G4 (IgG4)-related disease is known to have diverse clinical manifestations. We report a case of IgG4-related ophthalmic disease misdiagnosed as intraocular tumor. Methods: Case report. Results: A 41-year-old man was referred to our department with a diagnosis of intraocular tumor, presumably choroidal melanoma. Although MR imaging was compatible with choroidal melanoma, he had been observed periodically without treatment because fundus findings were not typical of melanoma and visual function was preserved. He was again referred to us 15 years later due to increased tumor size and visual field disturbance. Transscleral biopsy of the intraocular tumor was attempted to make a histopathological diagnosis. During the biopsy procedure, thick placoid tissue adhering to the sclera was found at a location consistent with the site of the elevated intraocular lesion. Histopathological examination of this extraocular material revealed proliferation of dense fibrous tissue with follicular proliferation of lymphocytes and plasmacytes. The plasmacytes were diffusely positive for IgG and IgG4. Serum IgG4 level was slightly elevated and no extraocular lesion was detected. Despite administration of systemic corticosteroids after biopsy, the intraocular mass was not reduced. Visual acuity of 20/20 has been maintained as of the last follow-up. Conclusion: IgG4-related disease should be included in the differential diagnosis of intraocular elevated lesion.

show abstract

“…The lacrimal glands also are commonly affected, causing IgG4-RD dacryoadenitis. 47 Other orbital complications, including thickening of the optic nerve, 48 masses around optic nerves, 49 scleritis, 50 oculomotor palsies, cavernous sinus thrombosis, 51 and retinopathy due to hyperviscosity 52 also have been described.…”

Section: Salivary and Lacrimal Glandsmentioning

confidence: 96%