IgG4 antibodies and cancer-associated inflammation

Karagiannis, Panagiotis; Gilbert, Amy E.; Nestle, Frank O.; Karagiannis, Sophia N.

doi:10.4161/onci.24889

Cited by 25 publications

(15 citation statements)

References 10 publications

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“… 30,31 Taken together, these indications point toward a role of CSR dysregulation associated with T H 2-biased response in driving the link between allergy, circulating IgE, and IgG4-related diseases including some cancers. 32 Nevertheless, our findings in individuals with high total IgE (≥100 kU/L) may be consistent with a potential requirement for a critical threshold toward a classical IgE, rather than an alternative IgG4-biased T H 2 immune response activation to confer for any potential protective benefits from cancer.…”

Section: Discussionsupporting

confidence: 80%

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

et al. 2016

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Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (Ptrend = 0.007) and in women (Ptrend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (TH2)-biased response in development of some cancers.

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Section: Discussionsupporting

confidence: 80%

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

et al. 2016

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“…Depending on the soluble signals released in the tumor microenvironment, B cells can be polarized to undergo class switching and express potentially weak immune-activating antibody isotypes such as IgG4 80 or IgG2 and IgA, 45 as part of chronic inflammation and immune-escape processes associated with human melanoma 79 (Figs. 1 and 2).…”

Section: B Cells In Melanoma Immune Surveillancementioning

confidence: 99%

B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

et al. 2017

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Evidence of tumor-resident mature B cell and antibody compartments and reports of associations with favorable prognosis in malignant melanoma suggest that humoral immunity could participate in antitumor defense. Likely striving to confer immunological protection while being subjected to tumor-promoting immune tolerance, B cells may engender multiple functions, including antigen processing and presentation, cytokine-mediated signaling, antibody class switching, expression and secretion. We review key evidence in support of multifaceted immunological mechanisms by which B cells may counter or contribute to malignant melanoma, and we discuss their potential translational implications. Dissecting the contributions of tumor-associated humoral responses can inform future treatment avenues.

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“…37 Interestingly, elevated serum IgG4 levels were found more frequently in the group with HGD or CRC. IgG4 has been described as an immune mediator in the context of malignancy, 38 and an abundance of mucosal IgG4 in UC has been associated with more severe disease activity and the presence of PSC. 39 Early identification of sub-clinical PSC, with an increased frequency of colorectal surveillance, may have had an impact on CRD detection and management.…”

Section: Ta B L Ementioning

confidence: 99%

Prevalence and long‐term outcome of sub‐clinical primary sclerosing cholangitis in patients with ulcerative colitis

Culver

Bungay

Betts

et al. 2020

Liver International

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IgG4 antibodies and cancer-associated inflammation

Cited by 25 publications

References 10 publications

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

Prevalence and long‐term outcome of sub‐clinical primary sclerosing cholangitis in patients with ulcerative colitis

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