1999
DOI: 10.1046/j.1523-1747.1999.00622.x
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IgG1 and IgG3 are the Major Immunoglobulin Subclasses Targeting Epitopes within the NC16A Domain of BP180 in Pemphigoid Gestationis

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Cited by 71 publications
(55 citation statements)
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“…4).20,40 Recent epitope mapping studies identified two well defined antigenic sites within a 22 amino acid segment of BP180 (NC16A2 and NC16A2.5) as the major anti genic targets of PG sera. 41 In contrast to findings in BP,26 reactivity to NC16A is dominated by IgGZ and IgG3 in PG patients. 41 As IgG3 and IgG1 are the IgG subclasses with the strongest complement-fixing prop erties, these observations may well explain complement deposition at the DEJ which is the most consistent immunopathological finding in the skin of PG patients .…”
Section: Pemphigoid Gestationismentioning
confidence: 80%
“…4).20,40 Recent epitope mapping studies identified two well defined antigenic sites within a 22 amino acid segment of BP180 (NC16A2 and NC16A2.5) as the major anti genic targets of PG sera. 41 In contrast to findings in BP,26 reactivity to NC16A is dominated by IgGZ and IgG3 in PG patients. 41 As IgG3 and IgG1 are the IgG subclasses with the strongest complement-fixing prop erties, these observations may well explain complement deposition at the DEJ which is the most consistent immunopathological finding in the skin of PG patients .…”
Section: Pemphigoid Gestationismentioning
confidence: 80%
“…3). Within this membraneproximal stretch of 76 amino acids, PG autoantibodies bind to five well-defined epitopes (designated NC16A1, NC16A2, NC16A2.5, NC16A3 and NC16A5) 42,43 (Fig. 4).…”
Section: Immunopathology and Diagnosismentioning
confidence: 99%
“…In contrast, PG sera do not react with epitope NC16A4, which is a major target of autoantibodies in lichen planus pemphigoides 46,47 . Analysis of immunoglobulin subclasses in PG sera demonstrated that antibodies to BP180 NC16A mainly belong to IgG1 and IgG3 isotypes 42 . This is in contrast to findings in bullous pemphigoid, where IgG4 is the major subclass of anti-BP180 NC16A autoantibodies 48 .…”
Section: Immunopathology and Diagnosismentioning
confidence: 99%
“…PG is driven by auto-antibodies directed to the hemidesmosomal adhesion molecule BP180. IgG auto-antibodies directed against the NC16A domain of BP180 can be found in 90% of patients with PG and, in some cases, remain positive after delivery (4)(5)(6)(7)(8). Autoantibodies against a second hemidesmosomal protein, BP230, have been reported in up to 16% of PG sera (9), but the frequency of anti-BP230 auto-antibodies in healthy controls was not determined in this Japanese study.…”
mentioning
confidence: 55%