IgG1 and IgG3 anti‐D in maternal serum and on the RBCs of infants suffering from HDN: relationship with the severity of the disease

Lambin, P.; Debbia, Martine; Puillandre, Philippe; Brossard, Y.

doi:10.1046/j.1537-2995.2002.00239.x

Cited by 31 publications

(24 citation statements)

References 32 publications

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“…An explanation for this finding is that it is easier for IgG1 subclass to cross the placenta than for IgG3 subclass, which causes more IgG1 in the sera of infants than IgG3. This is consistent with previous studies, which found that the proportion of IgG3 on infants' RBC is about three times lower than in maternal sera [3] . The concentration level of IgG4 showed no significant difference between HDN group and study infants without HDN.…”

Section: Discussionsupporting

confidence: 94%

“…Although ABO-HDN is usually a subclinical condition and less severe than Rh-HDN, a higher incidence of ABO-HDN makes it noticeable among newborn in China. There re-mains some uncertainty as to which of the IgG antibody subclasses might be more important in ABO-HDN while the effect of these subclasses is clear in RH-HDN [1][2][3] . However, currently, there are no satisfactory methods to predict ABO-HDN in the antepartum period.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of FcγRIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn

Zhang²,

Liu³

et al. 2009

Neonatology

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ABO-HDN is a common disease of newborn in China and currently there is no satisfactory method to predict it in the antepartum period. It has been reported that FcγRIIa (CD32) genotype is associated with both infectious diseases induced by bacteria and parasitemia. There is a relationship between IgG subclass and RH-HDN. To study the pathogenesis of ABO-HDN and to find reliable method to diagnose ABO-HDN, we investigated the polymorphism of FcγRIIa (CD32) and distribution of IgG subclass in infants with ABO-HDN and their mothers by polymerase chain reaction or ELISA assay. We observed that the frequency of HH131 ge- notype is lower in infants with ABO-HDN than in controls (p < 0.01), while the frequency of HR131 genotype is higher in ABO-HDN infants than that in controls (p < 0.01). The genotype HR131 and concentrations of IgG1 and IgG3 are significantly correlated with ABO-HDN. Our results demonstrated, for the first time, that there is a correlation between ABO-HDN and CD32, and different IgG subclass distribution. Our study may contribute to the development of an early diagnostic method for HDN.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Correlation of FcγRIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn

Zhang²,

Liu³

et al. 2009

Neonatology

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“…Furthermore, IgG1 anti-D subtypes are associated with increased severity, in contrast to IgG3 [13]. To our best knowledge, these interesting novel insights are not yet implemented in general practice.…”

Section: Introductionmentioning

confidence: 97%

Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn – review on current management and outcome

Zwiers

Kamp

Oepkes

et al. 2017

Expert Review of Hematology

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Introduction: Hemolytic disease of the fetus and newborn (HDFN) remains a serious pregnancy complication which can lead to severe fetal anemia, hydrops and perinatal death. Areas covered: This review focusses on the current prenatal management, treatment with intrauterine transfusion (IUT) and promising non-invasive treatment options for HDFN. Expert commentary: IUTs are the cornerstone in prenatal management of HDFN and have significantly improved perinatal outcome in the past decades. IUT is now a relatively safe procedure, however the risk of complications is still high when performed early in the second trimester. Non-invasive management using intravenous immunoglobulin may be a safe alternative and requires further investigation. ARTICLE HISTORY

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“…Anti -D can be quantifi ed by comparison with a standard in an AutoAnalyser or by fl ow cytometry. IgG1 appears to be more important than IgG3 in the pathogenesis of fetal anaemia [599] . IgG1 and IgG3 anti -D both cause HDFN, IgM, IgG2, and IgG4 do not [112] .…”

Section: 'Enzyme-only' Antibodiesmentioning

confidence: 89%

Rh and RHAG Blood Group Systems

Daniels

2013

Human Blood Groups

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IgG1 and IgG3 anti‐D in maternal serum and on the RBCs of infants suffering from HDN: relationship with the severity of the disease

Cited by 31 publications

References 32 publications

Correlation of FcγRIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn

Correlation of FcγRIIa (CD32) Polymorphism and IgG Antibody Subclasses in Hemolytic Disease of Newborn

Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn – review on current management and outcome

Rh and RHAG Blood Group Systems

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