IgG subclasses and avidity of antibodies to polysaccharide antigens in allogeneic BMT recipients after vaccination with pneumococcal polysaccharide and Haemophilus influenzae type b conjugate vaccines

Parkkali, T; Käyhty, Helena; Anttila, Marja; Ruutu, Tapani; Wuorimaa, Tomi; Soininen, Anu; Volin, Liisa; Ruutu, Petri

doi:10.1038/sj.bmt.1701967

Cited by 20 publications

(9 citation statements)

References 43 publications

(42 reference statements)

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“…5 Children given pneumococcal polysaccharide vaccines had shortlived responses of low avidity 22 in contrast to adults in Table 2 Summary of the EBMT vaccination recommendations whom the avidity was high. 23 There is no advantage in vaccinating the donor. In autologous SCT recipients, the response to a single dose of pneumococcal polysaccharide vaccine is poor regardless of the stem cell source 5,9 and remains decreased for several years after transplantation for lymphoma as compared to controls.…”

Section: Ebmt Vaccination Recommendations P Ljungman Et Almentioning

confidence: 99%

Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT

Ljungman

Engelhard

Cámara

et al. 2005

Bone Marrow Transplant

206

153

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Summary:Over the last 25 years, the numbers of hematopoietic stem cell transplant (SCT) patients have increased rapidly. Infections have been major obstacles for successful transplantation. Thus, infection prevention is very important in transplant recipients. As the results of transplantation have improved, the number of long-term survivors has increased. Vaccination is a potentially important strategy for reducing the risk for vaccinepreventable infections after SCT. The EBMT produced recommendations for vaccination of SCT recipients published in Bone Marrow Transplantation in 1995. This paper updates the previous recommendations based on current knowledge. Bone Marrow Transplantation (2005) 35, 737-746.

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Section: Ebmt Vaccination Recommendations P Ljungman Et Almentioning

confidence: 99%

Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT

Ljungman

Engelhard

Cámara

et al. 2005

Bone Marrow Transplant

206

153

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“…This class of immunoglobulins consists of four subclasses, each encoded by a separate C-region gene and endowed with unique biological functions that are important for an efficient humoral response to a given pathogen. Recently it was demonstrated that antibody responses to viral protein antigens mainly are restricted to IgG1, IgG3, or both (3,5,6,9); IgG2 generally is stimulated by carbohydrate antigens (12,15), whereas IgG4 most likely reflects chronic antigen stimulation (13). Therefore, the monitoring of specific IgG subclass profiles after vaccination, compared with natural virus infection, may give an insight into the mechanisms that drive antibody production in both conditions.…”

mentioning

confidence: 99%

Immunoglobulin G Subclass Profile of Antimeasles Response in Vaccinated Children and in Adults with Measles History

Топтыгина

Pukhalsky

Alioshkin

2005

Clin Vaccine Immunol

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The aim of this study was to investigate measles-specific immunoglobulin G (IgG) subclass profile in vaccinated children and in adults with natural infection. Serum samples were collected before and 30 days after vaccination. The sera from 51 late convalescent adults and seven adults with natural measles infection at the 12th day after onset of rash have been also investigated. Measles IgG antibodies and specific IgG subclasses were tested by enzyme-linked immunosorbent techniques. In children younger than 3 years, the predominant subclass was IgG3, which contributed, on average, 63.3% of the total IgG response. The contributions of specific IgG1 and IgG4 to the total IgG antimeasles response were lower (19.9% and 16.8%, respectively), whereas IgG2 was not found. In contrast, in the group of children older than 4 years, just IgG2 was a predominant subclass; it contributed 42.6% of the total IgG response. Other subclasses were also present but the contribution was much lower. In adult volunteers with measles history, IgG2 was a predominant subclass of total IgG. Thus, in early convalescence IgG2 contributed 62% of the total IgG response, whereas in late convalescence the contribution was lower (41.4%). There were no visible differences in IgG subclass composition between subjects with natural infection and vaccinated children except those below 3 years of age. The humoral immune response of such subjects is immature and the IgG2 subclass of virus-specific antibodies has not been revealed in the sera.

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“…Почему же тогда у маленьких детей, несмотря на большое количество В1-лимфоцитов, в кро-ви определяются буквально следы IgA? По-видимому, это связано с тем, что плазматические клетки, производные от В1-лимфоцитов, распо-ложены в основном в слизистых и синтезируют львиную долю секреторных IgA [12] [8,11], IgG2-антитела стимулируются углеводными антигена-ми [17], тогда как IgG4, наиболее вероятно, игра-ют важную роль при хронической антигенной стимуляции [18,19]. Однако все не так просто.…”

Section: Discussionunclassified

Age-Dependent Features of Evolving Humoral Immunity in Children

Топтыгина¹,

Semikina²,

Копыльцова³

et al. 2014

Med. immunol.

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Резюме. Формирование гуморального иммунитета было изучено у здоровых детей: 11-ти новорож-денных, 33-х детей в возрасте 4-8 месяцев, 32-х детей в возрасте 1-2 года, 17-ти детей в возрасте 4-5 лет, 25-ти детей в возрасте 6-8 лет, 15-ти детей 9-11 лет и 28-ми детей 14-16 лет. Исследование мембранных рецепторов В-клеток методом проточной цитофлюорометрии с использованием трехцветной флюо-ресцентной метки позволило охарактеризовать субпопуляции В1-лимфоцитов (CD19. Было пока-зано, что В1-клетки преобладали в крови новорожденных и детей до 5-ти лет жизни. Напротив, В2-клетки памяти практически не определялись у новорожденных и достигали более 20% у детей 15-ти лет. С другой стороны, было показано, что количество иммуноглобулинов IgG1-и IgG3-субклассов быстро возрастало, тогда как уровень IgG2-субкласса долго оставался ниже 50% от уровня взросло-го, достигая такового лишь после 11-ти лет. Мы полагаем, что возрастная динамика количества IgG-субклассов связана с возрастными изменениями в субпопуляционном составе В-клеток. By the contrary, B2 memory cells were nearly undetectable in newborns, and exceeded 20% in adolescents (by 15 years old). Meanwhile, it has been revealed that the amounts of IgG1 and IgG3 subclasses did progressively increase with age, whereas IgG2 remained decreased to 50% of adult values for a long time, and reached them by 11 years and later. We suggest that the age dynamics of IgG subclasses is connected with age-dependent changes in B cell subpopulations.

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IgG subclasses and avidity of antibodies to polysaccharide antigens in allogeneic BMT recipients after vaccination with pneumococcal polysaccharide and Haemophilus influenzae type b conjugate vaccines

Cited by 20 publications

References 43 publications

Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT

Vaccination of stem cell transplant recipients: recommendations of the Infectious Diseases Working Party of the EBMT

Immunoglobulin G Subclass Profile of Antimeasles Response in Vaccinated Children and in Adults with Measles History

Age-Dependent Features of Evolving Humoral Immunity in Children

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