IgG Subclass Specificity of Human Monocyte Receptor Sites

Huber, H.; Douglas, Steven D.; Nusbacher, Jacob; Kochwa, Shaul; Rosenfield, R. E.

doi:10.1038/229419a0

Cited by 117 publications

(38 citation statements)

References 10 publications

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“…The binding of sensitized erythrocytes to mononuclear phagocytes is limited to IgGl and IgG3 subclasses [4,5]. Published data about relative abilities of IgGl and IgG3 anti-D in mediating eryhrophagocytosis are contradictory.…”

Section: Introductionmentioning

confidence: 98%

Distribution of IgG Subtypes in Maternal Anti-D Sera and Their Prognostic Value in Rh Haemolytic Disease of the New-Born

Iyer¹,

Kulkarni²,

Gupte³

1992

Acta Haematol

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In 107 Rh(D)-immunized women having Rh(D)-positive pregnancy screening for IgG subtypes was carried out between the 34th and 36th week of gestation. Using polyclonal IgG subtype-specific reagents, all four IgG subclasses were detected in anti-D sera though IgGl and IgG3 were the most predominant classes. IgG3 anti-D was usually low titre. At the same level of Rh(D) antibody titre, haemolytic disease of the new-born was more severe when anti-D was IgGl type than IgG3 type. When the IgGl and IgG3 anti-D subtypes existed together, the risk of having a stillborn child was very high compared to other subtypes (IgG1 + IgG3 34.8%, IgG1 19.2% and IgG3 15.4%).

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Section: Introductionmentioning

confidence: 98%

Distribution of IgG Subtypes in Maternal Anti-D Sera and Their Prognostic Value in Rh Haemolytic Disease of the New-Born

Iyer¹,

Kulkarni²,

Gupte³

1992

Acta Haematol

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“…These mechanisms include cell opsonization followed by uptake by FcR-bearing phagocytes (31,32), activation of the complement cascade (33), and apoptosis via Ab-dependent cellular cytotoxicity (Refs. [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

CD8 Blockade Promotes Antigen Responsiveness to Nontolerizing Antigen in Tolerant Mice by Inhibiting Apoptosis of CD4+ T Cells

Wang

Davies

2007

The Journal of Immunology

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Using the DO11.10 CD4+ TCR-transgenic mouse system, we have recently shown that CD8 blockade promotes the expansion of Ag-specific regulatory CD4+ T cells in mice made tolerant to OVA with anti-CD4 mAb. We now show that CD8 blockade is also critical to promoting responses to nontolerizing Ag in anti-CD4 mAb-treated tolerant mice. Previously published work shows that treatment with anti-CD4 mAb without CD8 blockade induces Ag-specific tolerance. We now show that, in addition to inducing tolerance, anti-CD4 mAb treatment also significantly reduces responsiveness to irrelevant, nontolerizing Ag, and this unresponsiveness is associated with significant apoptosis of the CD4+ T cells. Anti-CD4 mAb-induced apoptosis is inhibited by cotreatment with anti-CD8 mAb and responsiveness to irrelevant Ag is restored, while Ag-specific tolerance is maintained. These data suggest that CD8 blockade promotes responsiveness to nontolerizing Ags in tolerant mice by inhibiting CD4+ T cell apoptosis.

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“…Specificity of binding between macrophage/monocyte surface receptors and subclasses of IgG has been shown in other animals also. In man only IgGi and IgG3 subclasses bind to monocyte receptors (Huber et al, 1971); in guinea-pig and goat IgG2 antibodies bind to macrophage surface receptors (Berken and Benacerraf, 1966;Micusan and Borduas, 1977). In contrast, all the subclasses of murine IgG bind to their receptors on homologous macrophages (Ralph et al, 1980).…”

Section: Inhibition Of Binding Of Crbc-lggl To Monolayers Of Macrophagesmentioning

confidence: 99%

“…In most species cytophilic antibodies have been found to occur almost exclusively in the IgG class (Tizard, 1971). Further study has shown that only certain subclasses of IgG are able to bind to these cells (Huber et al, 1971;Micusan and Borduas, 1977).…”

Section: Introductionmentioning

confidence: 99%

ANTIGEN‐SPECIFIC CYTOPHILIC ACTIVITY OF SHEEP IgG1 and IgG2 ANTIBODIES

Yasmeen¹

1981

Aust J Exp Biol Med

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Summary. Sheep were immunised with chicken red blood cells in the area drained by the popliteal lymph node and lymph was collected from the stimulated nodes. The immune lymph samples were fractionated into IgGl and IgG2 antibody fractions; these were then tested by passive direct and passive indirect rosette tests for antigen-specific cytophilic activity on adherent mononuclear cells (macrophages) from non-immunised sheep. Antigen-specific cytophilic activity for homologous macrophages appeared within a week following primary immunisation. Fractionation of the immune lymph showed that antibodies associated with IgGl, but not IgG2, subclass were highly active in promoting binding of the antigen to the macrophages. Pretreatment of the macrophages with uncomplexed IgGl from non-immunised sheep inhibited binding of cytophilic IgGl complexed with antigen.

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IgG Subclass Specificity of Human Monocyte Receptor Sites

Cited by 117 publications

References 10 publications

Distribution of IgG Subtypes in Maternal Anti-D Sera and Their Prognostic Value in Rh Haemolytic Disease of the New-Born

Distribution of IgG Subtypes in Maternal Anti-D Sera and Their Prognostic Value in Rh Haemolytic Disease of the New-Born

CD8 Blockade Promotes Antigen Responsiveness to Nontolerizing Antigen in Tolerant Mice by Inhibiting Apoptosis of CD4+ T Cells

ANTIGEN‐SPECIFIC CYTOPHILIC ACTIVITY OF SHEEP IgG1 and IgG2 ANTIBODIES

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