IgG subclass deficiency in children with congenital heart disease

Radford, Dorothy J.; Thong, Y.H.; Beard, Lorraine J.; Fèrrante, Antonio

doi:10.1111/j.1399-3038.1990.tb00007.x

Cited by 9 publications

(13 citation statements)

References 25 publications

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“…As mentioned in "Material and methods", dilutions of the sample sera were chosen which gave optimal sensitivity in the lower normal range for each subclass. This was based upon previously published results from testing of healthy populations (1)(2)(3)(4)(5). The lower limits of reading for the various IgG subclasses in our assay were therefore considerably higher than the values obtained as absolute lower limits of detection.…”

Section: Discussionsupporting

confidence: 56%

“…It is therefore of vital importance to establish such reference limits among the relevant population with the same method used for analysing patient sera. This is of importance in the evaluation of the child with recurrent infections, but may also be of etiological or pathogenetic significance in other diseases (1,2,4). In addition to the diagnostic value in the evaluation of the single patient, such reference limits may serve as a basis for studies of immunogiobulin levels in various diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Low values of serum immunogiobulin (Ig) G subclasses have been reported in several different clinical conditions including bronchial asthma, recurrent respiratory infections and congenital cardiac disease, mostly among children (1)(2)(3)(4). Several authors have reported their reference values of serum subclass IgG concentrations among healthy children.…”

mentioning

confidence: 99%

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Serum immunogiobulin G subclasses and serum immunogiobulin A in healthy Norwegian children and adults

Carisen

Mellbye²,

Fuglerud³

et al. 1992

Pediatric Allergy Immunology

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IgG subclass concentrations were determined by a capture ELISA antibody assay using monoclonal antibodies to IgG1, IgG2, IgG3, and IgG4. All the antibodies had been tested for specificity in an IUIS/WHO collaborative study, and this was confirmed by us by testing against purified myeloma proteins representing the 4 subclasses. The sera to be tested were diluted to obtain optimal sensitivity in the lower normal range for each subclass. With these serum dilutions, the lower limit of reading was 1. 2 g/l for IgG1, 0. 25 g/l for IgG2, 0.04 g/l for IgG3 and for IgG4. Age specific reference limits of the IgG subclass concentrations were determined in serum samples from 138 healthy infants and children under 14 years of age and 66 adults. The reference limits for each age group were determined by calculating the mean ± 2 SD of the logarithms to the values and then taking the antilog of the results. IgA was determined by a turbidimetric method with a reading limit of 0. 1 g/l, and the reference limits were calculated from serum samples from the 138 children under 14 years of age and from 31 healthy adults. The age specific reference limits of the IgG subclasses and IgA are given. Several infants and children had IgG4 levels below the lower reading limit. To determine lower reference limits of IgG4 below the age of 7 years was therefore of little clinical significance.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Serum immunogiobulin G subclasses and serum immunogiobulin A in healthy Norwegian children and adults

Carisen

Mellbye²,

Fuglerud³

et al. 1992

Pediatric Allergy Immunology

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“…It is well known that patients with DiGeorge syndrome display a variety of immunodeficiencies, most commonly of the T lymphocyte populations [3,4,11,14,20,24,27,31,37,38]. The purpose of this study was to determine the relation between immunodeficiencies and neural crest cardiovascular defects.…”

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confidence: 98%

Abnormalities in lymphocyte populations in infants with neural crest cardiovascular defects

et al. 1996

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The DiGeorge syndrome has been associated with various immune deficits. Embryologically, defects of the neural crest are associated with conotruncal and aortic arch abnormalities. The objective of this study was to determine if children with neural crest congenital heart defects can have subtle but significant immunodeficiencies. Complete blood counts with differential counts and a standard lymphocyte immunophenotyping panel of selected monoclonal antibodies were performed on peripheral blood from 20 children with neural crest cardiac disease and 34 normal newborns. The children with cardiac disease were grouped as survivors and nonsurvivors. The mean total white blood cell count was similar for all groups, but the percent lymphocytes was significantly less in the nonsurvivors than in the survivors and normal newborns (p < 0. 02). The lymphocyte subsets affected were CD2, CD3, and CD4. When the cardiac patients were compared to the normal newborns, again differences in lymphocyte subsets CD2, CD3, and CD4 were seen. When comparing nonsurvivors with survivors, the mean percentages of the CD2, CD3, and CD4 T lymphocyte markers, as well as the mean lymphocyte, B cell (CD20), and natural killer cell (CD16) percentages were all lower in the nonsurvivors. It was concluded that abnormalities in specific lymphocyte populations and their subsets may be predictors of infants at greatest risk for immunodeficiency complications. Therefore children with neural crest cardiac defects should have evaluations of lymphocyte subsets at birth and be treated as if potentially immunodeficient.

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“…We have previously reported abnormalities in total immunoglobulin levels in infants with acute bronchiolitis, and especially in infants with bronchiolitis later developing bronchial asthma (2,3). Low levels of serum immunoglobulin (Ig) G subclasses have been reported in several different clinical conditions, mostly among children, including recurrent respiratory infections, bronchial asthma and congenital cardiac disease (4)(5)(6)(7). Recently, we reported reference values of IgG subclasses and IgA in Norwegian children from infancy to adolescence (8), measuring IgG subclass levels by enzyme-linked immunosorbent assay (ELISA) using monoclonal antibodies to subclass-specific antigenic determi-nants on the IgG molecule.…”

mentioning

confidence: 99%

Serum immunoglobulin G subclasses and serum immunoglobulin A in acute bronchiolitis in infants

Carlsen¹,

Mellbye²,

Fuglerud

et al. 1993

Pediatric Allergy Immunology

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Serum IgG subclasses and Serum IgA were studied in 43 infants with acute bronchiolitis and 20 healthy infants. IgG subclasses were determined by a capture ELISA and IgA was quantified by turbidimetry. IgG1 concentrations were significantly lower in infants with bronchiolitis than in normal infants. The other IgG subclasses and IgA did not differ between the groups. The subgroups of infants with bronchiolitis who had previously suffered from otitis media or bronchitis, had significantly lower IgG2 than the other infants with bronchiolitis. The same was found for infants with bronchiolitis who had suffered from three or more lower respiratory tract infections. In infants who had suffered from upper or lower respiratory infections before the acute bronchiolitis, IgA was significantly higher than in infants without previous respiratory infections. Ten infants with bronchiolitis (23%) had IgG1 deficiency, that is values below the lower reference limit calculated in a population of healthy Norwegian infants. No healthy infants had any IgG1 deficiency. No infant with bronchiolitis had IgG2 or IgG3 deficiency. The low IgG1 values found in infants with acute bronchiolitis, may be one cause for infants to be more susceptible to RS virus infections.

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IgG subclass deficiency in children with congenital heart disease

Cited by 9 publications

References 25 publications

Serum immunogiobulin G subclasses and serum immunogiobulin A in healthy Norwegian children and adults

Serum immunogiobulin G subclasses and serum immunogiobulin A in healthy Norwegian children and adults

Abnormalities in lymphocyte populations in infants with neural crest cardiovascular defects

Serum immunoglobulin G subclasses and serum immunoglobulin A in acute bronchiolitis in infants

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