IgG subclass deficiencies in children: Facts and fiction

Wahn, V.; Bernuth, Horst von

doi:10.1111/pai.12757

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…For example, detection of IgG subclasses may help determine one’s susceptibility to infections. Children deficient in IgG2 or IgG3 would not display a satisfactory response to vaccines, especially polysaccharide vaccines, compared to those with normal IgG2 or IgG3 titers [ 4 ]. In addition, deficiencies are classified into different subtypes on the basis of IgG subclasses, according to the classification committee guidelines of the International Union of Immunological Societies [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A reference interval for serum IgG subclasses in Chinese children

Liu

Deng

et al. 2018

PLoS ONE

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BackgroundReference intervals (RIs) for serum IgG subclasses vary greatly among different geographical regions. The present study aimed to establish RIs for serum IgG subclasses in Chinese children, which is essential for interpretation of laboratory findings and making clinical decisions.MethodsThis study was performed in accordance with guideline C28-A3, proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. In total, 607 apparently healthy Chinese children were enrolled, and serum levels of IgG subclasses were measured. Individuals were stratified by age and the RIs were determined through statistical analysis.ResultsFollowing were the median values of RIs for serum IgG subclasses in Chinese children: IgG1, 2.78 g/L; IgG2, 0.85 g/L; IgG3, 0.13 g/L; IgG4, 0.06 g/L at 1–6 months of age; IgG1, 3.64 g/L; IgG2, 0.73 g/L; IgG3, 0.19 g/L; IgG4, 0.03 g/L at 6–12 months of age; IgG1, 5.15 g/L; IgG2, 0.87 g/L; IgG3, 0.19 g/L; IgG4, 0.07 g/L at 1–2 years of age; IgG1, 5.26 g/L; IgG2, 1.23 g/L; IgG3, 0.14 g/L; IgG4, 0.11 g/L at 2–3 years of age; IgG1, 6.33 g/L; IgG2, 1.8 g/L; IgG3, 0.2 g/L; IgG4, 0.21 g/L at age 3–4 years; IgG1, 7.05 g/L; IgG2, 1.87 g/L; IgG3, 0.25 g/L; IgG4, 0.29 g/L at 4–6 years of age; IgG1, 6.19 g/L; IgG2, 1.93 g/L; IgG3, 0.2 g/L; IgG4, 0.28 g/L at 6–9 years of age; IgG1, 6.76 g/L; IgG2, 2.29 g/L; IgG3, 0.27 g/L; IgG4, 0.37 g/L at 10–12 years of age; IgG1, 7.45 g/L; IgG2, 2.92 g/L; IgG3, 0.28 g/L; IgG4, 0.38 g/L at 13–16 years of age.ConclusionTo our knowledge, this study is the first to establish RIs for serum IgG subclasses exclusively in Chinese children.

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Section: Introductionmentioning

confidence: 99%

A reference interval for serum IgG subclasses in Chinese children

Liu

Deng

et al. 2018

PLoS ONE

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“…In addition, recurrent pulmonary infections and bronchiectasis have been reported in symptomatic patients. 18 Deficiencies in this IgG subclass have also been found in other patients with APDS. 19 These observations indicate that IgG2 and IgG4 subclass deficiencies, which are associated with recurrent RTIs and bronchiectasis, may be important immune features of APDS.…”

Section: Discussionmentioning

confidence: 88%

Activated phosphoinositide 3-kinase delta syndrome misdiagnosed as anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report

et al. 2021

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Activated phosphoinositide 3-kinase delta syndrome (APDS) is a combined inborn error of immunity mainly caused by PIK3CD mutations. We herein describe a 4-year-old Chinese boy who was admitted for recurrent pneumonia and persistent hematuria and exhibited multisystem involvement and anti-neutrophil cytoplasmic antibody (ANCA) positivity. He was initially diagnosed with ANCA-associated vasculitis. However, genetic testing revealed a c.1574A>G PIK3CD mutation, resulting in a diagnosis of APDS1.

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“…As an important humoral immunity molecule, IgG plays major roles in the fight against bacterial and viral infections as well as in mediating antibody-dependent cell-mediated cytotoxicity and complement activation. 6 IgG2 primarily provides a universal immune response against polysaccharide antigens, and IgG2 deficiency is associated with recurrent respiratory infections in children. 6 Serum IgG subtypes were previously detected during hospitalization and after discharge of patients with COPD with acute exacerbation, and it was found that IgG and IgG4 levels were significantly decreased, which may be an important reason for the susceptibility to infection in these patients.…”

Section: Discussionmentioning

confidence: 99%

Serum Proteomic Profiling in Patients with Chronic Obstructive Pulmonary Disease

Wu¹,

Huang²,

Chang³

et al. 2023

COPD

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Purpose Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with high morbidity and mortality rates. This study used proteomic profiling of serum to identify the differentially expressed proteins in COPD patients compared with healthy controls, to expand the knowledge of COPD pathogenesis and to ascertain potential new targets for diagnosis and treatment of COPD. Methods Serum samples were collected from 56 participants (COPD group n = 28; Healthy Control group n = 28). A data-independent acquisition quantitative proteomics approach was used to identify differentially expressed proteins (DEPs) between the two groups. Gene Ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functional enrichment, and protein–protein interaction analyses of DEPs were conducted to identify their relevant biological processes, cellular components, and related pathways. We used a parallel reaction monitoring (PRM)-based targeted quantitative proteomics approach to validate those findings. Results Of 8484 peptides identified by searching the UniProtKB/Swiss-Prot knowledgebase, 867 proteins were quantifiable, of which 20 were upregulated and 35 were downregulated in the COPD group. GO functional annotation indicated that the subcellular localization of most DEPs was extracellular. The top three molecular functions of the DEPs were signaling receptor binding, antigen binding, and immunoglobulin receptor binding. The most relevant biological process was immune response. The transforming growth factor-β signaling pathway, Staphylococcus aureus infection, and hematopoietic cell lineage were the top three pathways identified in the KEGG pathway functional enrichment. Our PRM analyses confirmed the identification of 11 DEPs identified in our data-independent acquisition analyses, 8 DEPs were upregulated and 3 DEPs were downregulated. Conclusion This study using data-independent acquisition analyses with PRM confirmation of findings identified 11 DEPs in the serum of patients with COPD. These DEPs are potential diagnostic or prognostic biomarkers or may be future targets for the treatment of COPD.

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IgG subclass deficiencies in children: Facts and fiction

Cited by 13 publications

References 27 publications

A reference interval for serum IgG subclasses in Chinese children

A reference interval for serum IgG subclasses in Chinese children

Activated phosphoinositide 3-kinase delta syndrome misdiagnosed as anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report

Serum Proteomic Profiling in Patients with Chronic Obstructive Pulmonary Disease

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