IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content

T-Cell Responses before and after the Fifth Consecutive Acellular Pertussis Vaccination in 4-Year-Old Dutch Children

“…Still, limited information on T-cell cytokine responses in young children is available since most studies that evaluated pediatric DTaP-IPV-Hib (HebB) and adult TdaP vaccines have focused on antibody responses against the different vaccine components (13,21,24,25). Pertussis-specific antibody levels found in the 4-year-old children in this study (13) vaccinated at 2, 3, 4, and 11 months of age were comparable with data from French children of the same age (12) vaccinated at 2, 4, and 18 months of age.…”

“…In this study, a cohort of children 4 years of age forms a subset of a cross-sectional observational study in The Netherlands (ISRCTN65428640) performed from 2007 (wP-primed children) onwards until 2008 (aP-primed children), which aimed to investigate pertussis-specific immunity in children 3 to 9 years of age. The pertussis vaccine-specific IgG antibody responses in these 4-year-old children have been published previously (13). Now, we evaluated T-cell immune responses in a randomly selected subset of these children (n ϭ 92).…”

“…Pertussis-specific antibody levels are induced by vaccination and natural infection and protect against disease; however, these levels decline very rapidly after vaccination (9,13). Several studies have shown that protection against disease also relies on T-helper (Th) cells, as well as antibodies (7,26).…”

An Ag-Dependent Approach Based on Adaptive Mechanisms for Investigating the Regulation of the Memory B Cell Reservoir

“…The same model was also used to investigate the factors that are potentially responsible for maximum immunization capacity [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Our results suggest that not only antigen type but also antigen mutation can influence the durability of immunizations, indicating that the role of antigen persistence is important for prolonging immune memory.…”

“…In 2009, Tarlinton et al [49] published a review paper, suggesting that the homeostasis of immune memory can only occur if new memory populations arise over others, i.e., to create dynamic equilibrium among memory cells, some need to disappear for others to arise, because the immune system has a maximum memory capacity [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Choo et al, in a recent paper published in The Journal of Immunology [57], reported the same finding, based on the Ag-independent premise.…”