IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

Mauch, Renan Marrichi; Nørregaard, Lena; Ciofu, Oana; Levy, Carlos Emílio; Høiby, Niels

doi:10.1016/j.jcf.2017.09.004

Cited by 7 publications

(5 citation statements)

References 19 publications

(21 reference statements)

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“…Thus, IL17-γδ T cells may help the bacterial clearance and improve survival via innate and humoral immunity. However, Bayes et al suggested that pathogenesis was unaffected in mice lacking B cells [98], supporting the idea that an elevated humoral response during chronic P. aeruginosa infection is not associated with clinical improvement [102]. Indeed, it is suggested that the high expression of specific anti-P. aeruginosa IgG may lead to the formation of circulating immune complexes, which are deposited in the lower airways tissue, triggering tissue damage and long-term deterioration of lung function [102].…”

Section: The Adaptive Responsementioning

confidence: 99%

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

Sainz-Mejías

Jurado‐Martín

McClean

2020

Cells

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Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and acute infections in immunocompromised individuals. The adaptability of this opportunistic pathogen has hampered the development of antimicrobial therapies, and consequently, it remains a major threat to public health. Due to its antimicrobial resistance, vaccines represent an alternative strategy to tackle the pathogen, yet despite over 50 years of research on anti-Pseudomonas vaccines, no vaccine has been licensed. Nevertheless, there have been many advances in this field, including a better understanding of the host immune response and the biology of P. aeruginosa. Multiple antigens and adjuvants have been investigated with varying results. Although the most effective protective response remains to be established, it is clear that a polarised Th2 response is sub-optimal, and a mixed Th1/Th2 or Th1/Th17 response appears beneficial. This comprehensive review collates the current understanding of the complexities of P. aeruginosa-host interactions and its implication in vaccine design, with a view to understanding the current state of Pseudomonal vaccine development and the direction of future efforts. It highlights the importance of the incorporation of appropriate adjuvants to the protective antigen to yield optimal protection.

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Section: The Adaptive Responsementioning

confidence: 99%

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

Sainz-Mejías

Jurado‐Martín

McClean

2020

Cells

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“…B cells respond robustly to chronic P. aeruginosa infection through production of high levels of P. aeruginosa -specific IgG and IgA antibodies (Abs) and immune complex formation. However, this robust humoral response is not associated with bacterial clearance or clinical improvement and has even in some cases been suggested to be detrimental ( 257 , 258 ). Though B cell responses were some of the earliest characterized responses to chronic lung P. aeruginosa infection ( 259 , 260 ), they remain poorly understood to this day ( 257 ).…”

Section: Immune Response To Infectionmentioning

confidence: 99%

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response

Nickerson,

Thornton,

Johnston

et al. 2024

Front. Immunol.

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Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen capable of exploiting barriers and immune defects to cause chronic lung infections in conditions such as cystic fibrosis. In these contexts, host immune responses are ineffective at clearing persistent bacterial infection, instead driving a cycle of inflammatory lung damage. This review outlines key components of the host immune response to chronic P. aeruginosa infection within the lung, beginning with initial pathogen recognition, followed by a robust yet maladaptive innate immune response, and an ineffective adaptive immune response that propagates lung damage while permitting bacterial persistence. Untangling the interplay between host immunity and chronic P. aeruginosa infection will allow for the development and refinement of strategies to modulate immune-associated lung damage and potentiate the immune system to combat chronic infection more effectively.

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“…Moreover, bacterial communities embedded in an extracellular matrix (ECM) form biofilms. P. aeruginosa biofilms are more resistant to host responses than their planktonic counterparts, which makes it difficult to remove the biofilms [7,8]. In order to solve the problem of food corruption caused by P. aeruginosa, it is necessary to continuously develop and improve effective antimicrobial strategies.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation

Song

Liu

et al. 2021

IJMS

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The aims of this study were to develop the magnolol–chitosan films and study the positive effect of the combination of magnolol and chitosan. The addition of magnolol made the magnolol–chitosan films exhibit higher density (1.06–1.87 g/cm3), but the relatively lower water vapor permeability (12.06–7.36 × 10−11·g·m−1·s−1·Pa−1) and water content (16.10–10.64%). The dense and smooth surface and cross-section of magnolol–chitosan films were observed by environmental scanning electron microscopy (ESEM) images. The interaction of magnolol and chitosan was observed by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). After the addition of magnolol, the antioxidant capacity of magnolol–chitosan films was increased from 18.99 to 82.00%, the growth of P. aeruginosa was inhibited and the inhibition percentage of biofilm formation was increased from 30.89 to 86.04%. We further verified that the application of magnolol–chitosan films on chilled pork significantly reduced the increases in pH value, inhibited the growth of microorganisms and extended the shelf life. Results suggest that magnolol had a positive effect on magnolol–chitosan films and could be effectively applied to pork preservation.

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IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

Abstract: IgG avidity to P. aeruginosa alginate does not significantly enhance as chronic lung infection progresses. This probably plays a role in the difficulty to mount an effective opsonophagocytic killing to clear mucoid P. aeruginosa infection in CF.

Cited by 7 publications

References 19 publications

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response

Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation

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