IgG Antibodies Against Food Antigens are Correlated with Inflammation and Intima Media Thickness in Obese Juveniles

Abstract

We show here, that obese children have significantly higher IgG antibody values directed against food antigens than normal weight children. Anti- food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. These findings raise the possibility, that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis.

Determination of the Effect of the Elimination Diet Applied for Overweight and Obese People with Food Intolerance on Body Composition and Biochemical Parameters

“…It was also revelaed that anti-food IgG antibodies are significantly correlated with low degree systemic inflammation and carotid artery intima media thickness. These findings have increased the possibiliy that IgG antibodies play a role in development of pathogenetic obesity and aterosclerosis [ 42 ]. According to comparison of the biochemical findings obtained before and after the elimination diet combined with personal weight-loss diet, there was an improvement in biochemical findings in general and the decrease of blood glucose, HbA1C, insulin, HOMA-IR, total cholesterol, LDL cholesterol, trigliserides, AST, GGT and ALT levels was statistically significant.…”

“…It has been proven that anti-food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. Those findings have raised the possibility that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis [ 17 ]. Elimination diets are frequently used in food intolerance or allergy, or gastrointestinal disorders and can also set the implementation of lifestyle changes needed to reduce chronic inflammation [ 18 ].…”

Obesity - A Promoter of Allergy?

“…Obesity is thought to lead to a state of low-grade systemic inflammation, with elevated levels of CRP and circulating leptin [16,21,35,37,42,46,63,64,65,66]. Leptin levels are elevated in obese subjects and reach the highest levels in obese asthmatics (e.g.…”

Nutrition and the Function of the Central Nervous System

“…A positive response to a diet based on IgG antibodies against food has been reported in several different diseases, such as migraine [49,80], obesity [81], Crohn disease [82]. A common thread of all above cases is inflammation.…”