“…They influence the T-cell response by enhancing antigen capture and delivery by modulating processing pathways, thus suppressing the generation of dominant antigenic determinants and by preventing processing (Watts and Lanzavecchia, 1993). We and others have used drug-protein conjugates to detect anti-drug antibodies in certain tolerant and allergic patients (de Haan et al, 1986;Christie et al, 1988;Daftarian et al, 1995;Torres et al, 1997). However, the dynamics of the drug antigen-specific humoral response and the kinetics of antibody production have not been defined.…”