IGFs and IGF-binding proteins in the regulation of human ovarian and endometrial function

Hs, Wang; Chard, Tim

doi:10.1677/joe.0.1610001

Cited by 86 publications

(63 citation statements)

References 138 publications

(128 reference statements)

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“…This indicated that the milieu in the uterus of the ovariectimized mouse was different from that in the normal one where the cellular events occur under the combined control of fluctuating estrogen, progesterone, LH, FSH as well as some local factors including EGF and IGF, etc. [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Tan

Sun

et al. 2006

Reprod. Nutr. Dev.

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-Small proline-rich proteins (SPRR) are known to construct the cornified cell envelope (CE) in the stratified squamous epithelial cell. Their functions in the simple epithelium such as the uterine epithelium are not clear hitherto. In the present study, the mRNA expression patterns of sprr2 family members in the mouse uterus and vagina during the estrous cycle and pregnancy as well as their regulation by steroids were investigated. Using semi-quantitative RT-PCR, it was revealed that the transcripts of sprr2b, 2e and 2g genes were up-regulated in the proestrous and estrous uteri, and sprr2d was up-regulated only in the estrous uterus. In the vagina, transcription of sprr2a, 2b, 2d, 2e and 2k genes were up-regulated at the metestrous stage. Northern blot analysis demonstrated that the overall expression of sprr2 was highly up-regulated in the estrous uterus and the metestrous vagina. During pregnancy, the sprr2 mRNA in the uterus was sharply repressed from day 3 postcoitus on, and began to be induced around labor time. In situ hybridization showed that the sprr2 transcripts were localized in uterine luminal and glandular epithelial cells as well as vaginal stratified epithelial cells. In ovariectomized mice, the expression of sprr2a, 2d, 2e and 2f genes in the uterus were induced by estrogen, and the effect of estrogen on sprr2d and 2e expression could be partly abolished by progesterone. The data indicate that the sprr2 genes have unique regulation patterns in different reproductive tissues under different physiological conditions, and the encoded proteins might play diverse functions in the female reproductive system. small proline-rich protein / uterus / estrous cycle / pregnancy / stress

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Section: Discussionmentioning

confidence: 99%

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Tan

Sun

et al. 2006

Reprod. Nutr. Dev.

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show abstract

“…Both conditions are characterized by insulin resistance, hyperpulsatile gonadotropin secretion, hyperactive ovarian and adrenal androgen synthesis, and decreased levels of insulin-like growth factor binding protein-1 (IGFBP-1) and sex hor- mone-binding globulin (SHBG). (34)(35) Insulin and insulin-like growth factor-I (IGF-I) stimulate ovarian growth and potentiate the actions of gonadotropins on ovarian steroid synthesis. Insulin also augments the bioactive concentrations of IGF-I and androgens through regulation of the synthesis of their respective binding proteins (IGFBP-1 and SHBG) in the liver.…”

Section: Genetics and Pcosmentioning

confidence: 99%

“…(34) At the onset of puberty, increased pulsatile growth hormone (GH) secretion results in insulin resistance and compensatory hyperinsulinemia which in turn stimulate the growth spurts. (35)(36)(37) Insulin resistance with compensating hyperinsulinism is also a common feature of PCOS. The increased serum insulin levels further decrease hepatic synthesis of IGFBP-1 and in turn enhance the bioactivity of IGF-I.…”

Section: Genetics and Pcosmentioning

confidence: 99%

“…The increased serum insulin levels further decrease hepatic synthesis of IGFBP-1 and in turn enhance the bioactivity of IGF-I. (35) Thus, it is plausible to speculate that there is an association between PCOS and puberty. Specifically, the progressively increasing insulin levels and IGF-I activity during puberty may act as inducing factors in the development of PCOS in susceptible subjects.…”

Section: Genetics and Pcosmentioning

confidence: 99%

“…(47) These findings indicate that a decrease in IGFBP-1 produced by granulosa cells may insufficiently antagonize IGF-I bioactivity in theca-stromal cells, resulting in overproduction of androgens and in turn defective follicular maturation and ovulation. (35) …”

Section: Pcos and Insulin-like Growth Factor (Igf)/igf Binding Proteimentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis of Polycystic Ovary Syndrome

Chang¹,

Katz²

1999

Endocrinology and Metabolism Clinics of North America

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Autosomal‐recessive syndrome with alopecia, hypogonadism, progressive extra‐pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1

Alsemari

Bohlega

2006

American J of Med Genetics Pt A

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We explored the manifestations of an autosomal-recessive multisystemic disorder in several Saudi families. Recognized causes of progressive extra-pyramidal disorder and white matter disease were excluded and the neurological, imaging, endocrine, and skin manifestations of this syndrome described. The onset of these symptoms in these patients began in early adolescence and progressed more rapidly in males. All affected patients had total or partial alopecia, clinical and chemical evidence of hypogonadism (low levels of estradiol and testosterone); females had clear evidence of hypogonadism (streak or absent ovaries), and some patients had diabetes mellitus and/or sensorineural deafness. The constant biochemical abnormality was the low IGF-1. The neurological manifestations included moderate to severe intellectual decline and abnormality of muscle tone and posture with choreo-athetoid and dystonic movements resulting in gait difficulty, dysarthria, difficulty swallowing, and scoliosis. The MRI of brain demonstrated white matter involving cerebellum, brain stem, and cerebral structures, as well as abnormal decreased signal intensity in the basal ganglia with involvement of the substantia nigra. We conclude that the association of hypogonadism, alopecia, and persistent low IGF-1 is a significant autosomal recessive syndrome; it is prevalent in Saudi Arabia. We also demonstrate that the progressive extra-pyramidal disorder, white matter disease, and abnormal signals of the basal ganglia are common features of this syndrome. Sensorineural deafness and diabetes mellitus were recognized features.

show abstract

IGFs and IGF-binding proteins in the regulation of human ovarian and endometrial function

Cited by 86 publications

References 138 publications

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Diagnosis of Polycystic Ovary Syndrome

Autosomal‐recessive syndrome with alopecia, hypogonadism, progressive extra‐pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1

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