IGFBP7 Concentration May Reflect Subclinical Myocardial Damage and Kidney Function in Patients with Stable Ischemic Heart Disease

Abstract

The objective of this study was to determine the associations between insulin-like growth-factor-binding protein 7(IGFBP7) concentrations and concentrations of troponin T(TnT), N-terminal pro-B-type natriuretic peptide(NT-proBNP) and the parameters of kidney function in patients with stable ischemic heart disease(IHD). The IHD group consisted of 88 patients, and the population group comprised 66 subjects without a history of IHD. IGFBP7, TnT and NTproBNP concentrations were measured. The IGFBP7 value was considerably higher in the IHD group (1.76 ± 1 ng/mL vs. 1.43 ± 0.44 ng/mL, respectively, p = 0.019). Additionally, IHD subjects had a significantly higher concentration of TnT and NTproBNP. In both groups there was a significant correlation between IGFBP7 and serum parameters of kidney function (creatinine concentration: population gr. r = 0.45, p < 0.001, IHD gr. r = 0.86, p < 0.0001; urea concentration: population gr. r = 0.51, p < 0.0001, IHD gr. r = 0.71, p < 0.00001). No correlation between IGFBP7 and microalbuminuria or the albumin to creatinine ratio in urine was found. Moreover, there was a significant correlation between IGFBP7 concentration and markers of heart injury/overload-TnT and NT-BNP(r = 0.76, p < 0.001 and r = 0.72, p < 0.001, respectively). Multivariate regression analysis in joint both revealed that the IGFBP7 concentration is independently associated with urea, creatinine and TnT concentrations (R2 for the model 0.76). IHD patients presented significantly higher IGFBP7 concentrations than the population group. Elevated IGFBP7 levels are associated predominantly with markers of kidney function and myocardial damage or overload.

Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma

“…In patients affected by ischemic heart disease (IHD), Lisowska et al found an average 1.25-fold increase in IGFBP7 serum levels in comparison to the population (1.76 ± 1 ng/mL vs. 1.43 ± 0.44 ng/mL, respectively, p = 0.019) [ 69 ]. Regarding our study, most of the patients grouped under the category of cardiovascular diseases exhibited solely arterial hypertension.…”

“…It is important to note that tumor markers can be altered by certain comorbidities. There are studies that show an association between specific comorbidities and IGFBP7 or ANXA1 [ 69 , 70 , 83 ]. As blood samples for our study were taken from all patients the day before surgery or panendoscopy as part of the standard preoperative examination, acute inflammatory processes or exacerbations of disease can be reliably excluded, as the patients would otherwise not have been applicable for the operation.…”

Screening of the Key Genes and Signaling Pathways for Schizophrenia Using Bioinformatics and Next Generation Sequencing Data Analysis

“…GPCR ligand binding [60], extracellular matrix organization [61], cytokine signaling in immune system [62], interferon signaling [63], signaling by GPCR [64], neuronal system [65] and platelet activation, signaling and aggregation [66] plays an important role in the schizophrenia. Studies have revealed that SIX1 [67], VIP (vasoactive intestinal peptide) [68], GATA6 [69], FRZB (frizzled related protein) [70], CD40 [71], WT1 [72], PCDHGA3 [73], TFAP2B [74], HFE (homeostatic iron regulator) [75], NKX2-5 [76], IGFBP7 [77], HLA-F [78], CCL2 [79], COL1A2 [80], RUNX1 [81], TFF3 [82], IRX4 [83], NOS1 [84], DKK2 [85], IL18R1 [86], ADAM12 [87], NPPC (natriuretic peptide C) [88], COL1A1 [89], ABCG2 [90], SIX2 [91], CSRP1 [92], MR1 [93], NINJ2 [94], ACE (angiotensin I converting enzyme) [95], TBX1 [96], CTSC (cathepsin C) [97], DLX6 [98], KCNE1 [99], AZGP1 [100], CYP1B1 [101], PRRX1 [102], CD34 [103], A2M [104], CDKN2A [105], SERPINE1 [106], CD44 [107], FABP4 [108], ITGB3 [109], ALOX5AP [110], DAND5 [111], SFRP4 [112], RUNX2 [113], TACR3 [114], MYD88 [115], CYBA (cytochrome b-245 alpha chain) [116], STAT6 [117], FOXC1 [118], FN1 [119], TLR6 [120], CAV1 [121], RGS4 [122], TPM2 [123], TNFSF4 [124], LOX (lysyl oxidase) [125], SMOC2 [126], SPHK1 [127], FOLH1 [128], CYP2C8 [129], CD163 [130], DIRAS3 [131], OSMR (oncostatin M receptor) [132], POSTN (peri...…”

Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly

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