IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression

Chao, Chia‐Chia; Lee, Wei-Fang; Yang, Wei-Hung; Lin, Chih-Yang; Han, Chien-Kuo; Huang, Yuan‐Li; Fong, Yi‐Chin; Wu, Min-Huan; Lee, I-Te; Tsai, Yuan-Hsin; Tang, Chih‐Hsin; Liu, Ju-Fang

doi:10.1016/j.lfs.2020.118758

Cited by 17 publications

(10 citation statements)

References 51 publications

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“…LOX (Lysyl Oxidase) has been suggested to be tumour suppressor in OS [63] , however we and others have shown that it is linked to hypoxia and plays a pro-tumorigenic role in cancers that metastasis to bone, inducing the pre-metastatic niche both in soft tissues such as lungs and in bone via formation of osteolytic lesion [64] . PDGFB is also linked to hypoxia and has been shown to be involved in OS cell proliferation and migration [65] , and IGFBP3 has also been shown to stimulate OS migration [66] . The BMP4 protein, part of the bone morphogenetic family which are known critical regulators of bone formation and remodelling, has recently been shown to be the most frequently expressed BMP in musculoskeletal tumours, including OS, in a recent study of 1,361 patients with 22 types of musculoskeletal tumours [67] .…”

Section: Discussionmentioning

confidence: 99%

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

Tattersall

Shah

Lath

et al. 2021

Journal of Bone Oncology

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Section: Discussionmentioning

confidence: 99%

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

Tattersall

Shah

Lath

et al. 2021

Journal of Bone Oncology

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“…IGFBP protease cleaves IGFBP into fragments with a lower affinity for IGF ligands, thereby improving the bioavailability of free IGF (Peters et al, 2003;Ianza et al, 2021). Three main proteases can cleave IGFBP, including serine proteases, cathepsins, and matrix metalloproteinases (MMPs) (Grimberg and Cohen, 2000;Garcia-Touchard et al, 2005;Chao et al, 2021). The IGF in the intervertebral disc may come from two sources: 1.…”

Section: Igf Signalingmentioning

confidence: 99%

IGF Signaling in Intervertebral Disc Health and Disease

Lin

Tian

Peng

et al. 2022

Front. Cell Dev. Biol.

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Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited. Insulin-like growth factor (IGF) signaling pathways play an important role in regulating different cell processes, including proliferation, differentiation, migration, or cell death, which are critical to the homeostasis of tissues and organs. The IGF signaling is crucial in the occurrence and progression of IVDD. The activation of IGF signaling retards IVDD by increasing cell proliferation, promoting extracellular matrix (ECM) synthesis, inhibiting ECM decomposition, and preventing apoptosis and senescence of disc cells. However, abnormal activation of IGF signaling may promote the process of IVDD. IGF signaling is currently considered to have a promising treatment prospect for IVDD. An in-depth understanding of the role of IGF signaling in IVDD may help find a novel approach for IVDD treatment.

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“…High levels of IGFBP-3 expression have been detected in head and neck cancer 14 and are correlated with poor clinical outcomes in breast cancer 15,16 . Exogenous IGFBP-3 is also known to promote cell migration by upregulating transcription of the gene that encodes vascular cell adhesion molecule 1 (VCAM-1) in osteosarcoma cells 17 . Thus, IGFBP-3 may act as either an oncogene or tumor suppressor depending on cellular context and tumor type.…”

Section: Roles Of Igfbp-3 In Cell Migration and Growth In An Endophyt...mentioning

confidence: 99%

Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line

Kaida

Nojima

et al. 2022

Sci Rep

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Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer. We previously found that IGFBP3 mRNA levels are higher in endophytic-type human tongue squamous cell carcinoma (TSCC) that is more invasive and more prone to metastasis than exophytic and superficial types. This finding prompted us to investigate the roles of IGFBP-3 in TSCC using SAS cells, which were originally derived from endophytic-type TSCC. Specifically, we used SAS cells that express a fluorescent ubiquitination-based cell-cycle indicator (Fucci). RNA-sequencing analysis indicated that IGFBP-3 is associated with cell migration and cell growth. In fact, IGFBP-3 knockdown downregulates cell migration and causes cells to arrest in G1. This migratory potential appears to be cell cycle–independent. IGFBP-3 knockdown also reduced levels of secreted IGFBP-3; however, decreased migratory potential was not rescued by exogenous recombinant human IGFBP-3. Furthermore, ERK activity was downregulated by IGFBP-3 depletion, which suggests that MEK/ERK signaling may be involved in IGFBP-3-mediated cell migration. We therefore conclude that intracellular IGFBP-3 enhances cell migration independently of the cell cycle in TSCC with a higher metastatic potential.

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IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression

Cited by 17 publications

References 51 publications

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

IGF Signaling in Intervertebral Disc Health and Disease

Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line

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