IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
Lauren R. Miller,
Marisa A. Bickel,
Stefano Tarantini
et al.
Abstract:IntroductionCerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 (IGF-1), a vasoprotective hormone, decrease during aging. Decreased circulating IGF-1 in animal models leads to the development of VCID-like symptoms, but the cellular mechanisms underlying IGF-1-deficiency associated pathologies in the aged cerebrovasculature remain poorly understood. Here, we test the hypothesis … Show more
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