IGF-II gene region polymorphisms related to exertional muscle damage

Devaney, Joseph M.; Hoffman, Eric P.; Gordish‐Dressman, Heather; Kearns, Amy K.; Zambraski, Edward J.; Clarkson, Priscilla M.

doi:10.1152/japplphysiol.01165.2006

Cited by 57 publications

(55 citation statements)

References 45 publications

(56 reference statements)

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“…Interestingly, this variant showed sexually dimorphic results: only males had an association in both cohorts, which is consistent with the previous EMD and FAMuSS cohorts (17,19), and additional articles showing the genetic influence on fitness phenotypic traits (24,25). This suggests that the sex-specific genetic architecture influencing phenotypes needs to be incorporated into the design of individualized exercise interventions to optimize results.…”

Section: Discussionsupporting

confidence: 85%

“…In addition, we wanted to compare and quantitate the genotype effect on an acute exercise intervention (single bout) versus a long-term 12-week resistance training intervention. Therefore, we included the following two different exercise cohorts: 1) Eccentric Muscle Damage (EMD) cohort allowed us to evaluate the effects of acute resistance exercise to exhaustion (16,17); and 2) the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS) provided evaluation of a chronic resistance exercise program, a longitudinal 12-week resistance exercise training cohort (18,19). In this article, we demonstrated that two copies of the protective allele (TT) against the development of T2D are associated with a positive response to an acute resistance training exercise bout and show an association with pre-exercise measures of skeletal muscle size and strength.…”

Section: Slc30a8 Nonsynonymous Variant Is Associated With Recovery Fomentioning

confidence: 99%

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SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

et al. 2013

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Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults—the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)—were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training.

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Section: Discussionsupporting

confidence: 85%

Section: Slc30a8 Nonsynonymous Variant Is Associated With Recovery Fomentioning

confidence: 99%

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

et al. 2013

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“…Current evidence supports the contribution of genetic elements to the process of exercise-induced muscle damage and repair (Clarkson et al 2005;Dennis et al 2004;Devaney et al 2007). Moreover, inXammatory responses show high inter-individual variability and have been associated with cytokine gene variations (Dennis et al 2004;Malm et al 2000).…”

Section: Introductionmentioning

confidence: 67%

IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise

et al. 2008

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Exertional rhabdomyolysis is a complex and poorly understood entity. The inflammatory system has an important role in muscle injury and repair. Serum creatine kinase (CK) is often used as systemic biomarker representing muscle damage. Considerable variation exists in CK response between different subjects. Genetic elements may act as predisposition factors for exertional rhabdomyolysis. Based on their biological activity, we hypothesized that in healthy subjects IL6 G-174C and TNFA G-308A promoter polymorphisms would be associated with CK response to exercise. We determined serum CK activity pre- and post-maximal eccentric contractions of the elbow flexor muscles. IL6 G-174C and TNFA G-308A genotypes were analyzed for possible relationship with changes in serum CK activity. IL6 G-174C genotype was associated with CK activity in a dose-dependent fashion. Subjects with one or more of the -174C allele had a greater increase and higher peak CK values than subjects homozygous for the G allele (mean +/- SE U/L: GG, 2,604 +/- 821; GC, 7,592 +/- 1,111; CC, 8,403 +/- 3,849, ANOVA P = 0.0003 for GG + GC genotypes versus CC genotype, P = 0.0005 for linear trend). IL6-174CC genotype was associated with a greater than threefold increased risk of massive CK response (adjusted odds ratio 3.29, 95% confidence interval 1.27-7.85, P = 0.009). A milder association (P = 0.06) was noted between TNFA G-308A genotype and CK activity. In conclusion, we found a strong association of the IL6 G-174C genotype with systemic CK response to strenuous exercise. Data suggest that homozygosity for the IL6-174C allele is a clinically important risk factor for exercise-induced muscle injury, further supporting the central role of cytokines in the reactive inflammatory process of muscle damage and repair.

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“…SNP en el gen de la IGF-2 (rs3213220 y rs680) se asocian a un aumento de la pérdida de fuerza, dolor y aumento de la actividad de la CK después de la realización de ejercicio excéntrico 24 . Otros estudios indican que genes relacionados con la estructura muscular (ACTN3) o que contribuyen al crecimiento (IGF-2), a la inflamación (IL-6, TNF␣) y a la producción de fuerza (MYLK) pueden presentar SNP que afectan a los niveles de CK y aumentar la respuesta al daño muscular producido por el ejercicio excéntrico.…”

Section: Genética Y Patologías Del Tejido Conectivo Estudios Previosunclassified

Cómo puede afectar el componente genético la lesionabilidad de los deportistas

Pruna

Artells²

2015

Apunts. Medicina de l'Esport

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IGF-II gene region polymorphisms related to exertional muscle damage

Cited by 57 publications

References 45 publications

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise

Cómo puede afectar el componente genético la lesionabilidad de los deportistas

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