IGF-1, inflammation and stem cells: interactions during muscle regeneration

Mourkioti, Foteini; Rosenthal, Nadia

doi:10.1016/j.it.2005.08.002

Cited by 226 publications

(194 citation statements)

References 70 publications

(112 reference statements)

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“…Although it has been classified as both a pro-and anti-inflammatory cytokine, the current view is that it acts primarily as an anti-inflammatory factor (18,24). Our data on inflammation-dependent biomarkers seem to support the concept of a balance between pro-inflammatory and anti-inflammatory factors, which coordinate inflammation and regeneration processes during muscle regeneration (13). An acute inflammatory response appeared to accompany the adaptation process following damage in the present study.…”

Section: Discussionsupporting

confidence: 78%

“…The molecular mechanisms involved in the muscle repair process following damage include an inflammatory response within the damaged muscle (13,23). Damage-induced cytokine responses have been demonstrated by increased concentrations of IL-1, IL-6 and IL-10 following high-intensity eccentric exercise (10,16).…”

Section: Discussionmentioning

confidence: 99%

“…Muscle adaptation that occurs following damage has been explained by the classic damage-inflammation-regeneration process (8,13,14). It is thought that exercise-induced muscle damage is associated with aseptic inflammation, and the primary purpose of this inflammation is the repair of damaged tissue (8,11).…”

Section: Introductionmentioning

confidence: 99%

“…It is thought that exercise-induced muscle damage is associated with aseptic inflammation, and the primary purpose of this inflammation is the repair of damaged tissue (8,11). Coordination between inflammation and regeneration is crucial for successful recovery of damaged muscle (13). Also, much of the acute inflammatory response induced by muscle damage is coordinated by the de novo synthesis of endogenous cytokines that direct inflammatory-related events (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Systemic cytokine response following exercise-induced muscle damage in humans

Philippou

Bogdanis

Maridaki

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Muscle adaptation which occurs following eccentric exercise-induced muscle damage has been associated with an acute inflammatory response. The purpose of this study was to investigate serum interleukin-6 (IL-6), osteoprotegerin and receptor activator of nuclear factor kB ligand (OPG/ RANKL) concentrations following muscle damage. We measured changes for several days following muscle damage. Methods: Ten healthy young males performed an eccentric exercise protocol using their quadriceps. Blood samples were withdrawn before and at 6 h, 2 days, 5 days and 16 days post-exercise. Functional and clinical measurements were performed before, and on days 1, 2, 5, 8, 12 and 16 post-exercise. Results: The exercise protocol resulted in muscle damage, indicated by changes in biochemical markers. An increase in IL-6 and OPG, and a decrease in RANKL concentrations were seen at 6 h and on day 2 post-exercise; the OPG:RANKL ratio was increased at 6 h post-exercise (p-0.05). Conclusions: Changes in IL-6 and OPG/RANKL system may represent systemic responses in muscle inflammation and repair processes. However, further studies are needed to elucidate a potential systemic and/ or local role of the OPG/RANKL system in skeletal muscle repair. Clin Chem Lab Med 2009;47:777-82.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic cytokine response following exercise-induced muscle damage in humans

Philippou

Bogdanis

Maridaki

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…Prior studies have cited high rates of IGF-1 in midlife as strong correlates of earlier mortality (Yuan et al 2009). IGF-1 is a circulating hormone of the somatotropic axis (growth hormone (GH)-IGF-1) that increases protein synthesis, accelerates cell cycle, and blocks initiation of apoptosis (Mourkioti and Rosenthal 2005). Because the insulin/IGF-1 signaling (IIS) pathway has been linked to lifespan in numerous model organisms including Caenorhabditis elegans, Drosophila melanogaster, and mice (Bartke 2008;Clancy et al 2001;Guarente and Kenyon 2000;Tatar et al 2001), it has long been of interest to gerontologists.…”

Section: Discussionmentioning

confidence: 99%

Inflammation and mortality in a frail mouse model

Qin

et al. 2011

AGE

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Mice homozygous for targeted deletion of the interleukin 10 gene (Il-10) have been partially characterized as a model for human frailty. These mice have increased serum interleukin (IL)-6 in midlife, skeletal muscle weakness, and an altered skeletal muscle gene expression profile compared to age and sex-matched C57BL/6 (B6) control mice. In order to further characterize for use as a frailty model, we evaluated the evolution of inflammatory pathway activation, endocrine change, and mortality in these mice. Serum was collected in groups of ageand sex-matched B6.129P2-Il10 tm1Cgn /J (IL-10 tm/tm ) mice and B6 control mice at age 12, 24, 48, 72, and 90 weeks. Cytokines including IL-6, interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), chemokine (C-X-C motif) ligand 1 (KC), IL-12, and IL-10 were measured using electro-chemiluminescent multiplex immunoassay and insulin-like growth factor 1 (IGF-1) was measured using solid-phase enzyme-linked immunosorbent assay. A separate longitudinal cohort was monitored from age 35 weeks to approximately 100 weeks. Survival was evaluated by Kaplan-Meier survival estimates and detailed necropsy information was gathered in a subset of mice that died or were sacrificed. In IL-10 tm/tm mice compared to B6 controls, serum IL-6, IL-1β, TNF-α, IFN-γ, KC levels were significantly elevated across the age groups, serum mean IGF-1 levels were higher in the 48-week-old groups, and overall mortality rate was significantly higher. The quadratic relationship between IGF-1 and age was significantly different between the two strains of mice. Serum IL-6 was positively associated with IGF-1 but the effect was significantly larger in IL-10 tm/tm mice. These findings provide additional rationale for the use of the IL-10 tm/tm mouse as a model for frailty and for lowgrade inflammatory pathway activation.

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Herzregeneration: Chancen und Aufgaben für die Wirkstoff‐Forschung mit neuartigen chemischen und therapeutischen Methoden oder Agentien

et al. 2014

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Infolge eines Herzinfarkts kann mehr als eine Milliarde Herzmuskelzellen (Kardiomyozyten) abgetötet werden, was zu Herzinsuffizienz und plötzlichem Tod führt. Heute konzentriert sich die Forschung in diesem Zusammenhang verstärkt auf die Regeneration von Herzgewebe durch die Differenzierung von Stammzellen, die Proliferation vorhandener Kardiomyozyten und Herzprogenitorzellen sowie die Umprogrammierung von Fibroblasten zu Kardiomyozyten. Hierfür gibt es eine Reihe möglicher Lösungsansätze, vom Einsatz niedermolekularer Verbindungen und RNA (einschließlich Mikro‐RNA und Anti‐Mikro‐RNA) bis hin zur Verwendung modifizierter Peptide und Proteine. Wir stellen in diesem Aufsatz aktuelle Entwicklungen in diesem Bereich vor und beschreiben dabei sowohl die jeweilige Methode und ihre Fortschritte, einschließlich neuartiger Screening‐Strategien zur Identifizierung von Treffern, als auch ihre Perspektiven für die Weiterentwicklung dieser Treffer hin zu Medikamenten, wobei die Chemie eine Schlüsselrolle spielt.

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IGF-1, inflammation and stem cells: interactions during muscle regeneration

Cited by 226 publications

References 70 publications

Systemic cytokine response following exercise-induced muscle damage in humans

Systemic cytokine response following exercise-induced muscle damage in humans

Inflammation and mortality in a frail mouse model

Herzregeneration: Chancen und Aufgaben für die Wirkstoff‐Forschung mit neuartigen chemischen und therapeutischen Methoden oder Agentien

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