IGF-1 induces sex-specific oxidative damage and mortality in a songbird
Ádám Z. Lendvai,
Zsófia Tóth,
Katharina Mahr
et al.
Abstract:The insulin-like growth factor 1 (IGF-1) is a pleiotropic hormone that regulates essential life-history traits and is known for its major contribution to determining individual ageing processes. High levels of IGF-1 have been linked to increased mortality and are hypothesised to cause oxidative stress. This effect has been observed in laboratory animals, but whether it pertains to wild vertebrates has not been tested. This is surprising because studying the mechanisms that shape individual differences in lifes… Show more
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