IgE to cross-reactive carbohydrate determinants: Origins, functions, and confounding role in nPhl p 4-IgE assays

Matricardi, Paolo Maria

doi:10.1016/j.jaci.2020.04.012

Cited by 4 publications

(9 citation statements)

References 10 publications

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“…Moreover, this specific double sensitization profile to pan‐allergens is not linked to any particular pollen 36 . At this moment, other grass allergens present a limited diagnostic value for AIT decisions and some of them provide confounding information due to lack of specificity 43 …”

Section: Crd and Selection Of Preparations For Aitmentioning

confidence: 99%

Molecular allergology and its impact in specific allergy diagnosis and therapy

Barber

Díaz-Perales

Escribese

et al. 2021

Allergy

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Section: Crd and Selection Of Preparations For Aitmentioning

confidence: 99%

Molecular allergology and its impact in specific allergy diagnosis and therapy

Barber

Díaz-Perales

Escribese

et al. 2021

Allergy

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“…Those studies demonstrated not only that the CCD recognized by the patients' IgE antibodies are heterogeneous, but also suggested that grass pollen might be the first and most frequent inducer of this category of antibodies not only in Europe but also worldwide 454 . Both, group 1 and group 4 allergen molecules in grass pollen are glycosylated, so the question which of the two (or both) are contributing to the induction of IgE antibodies to CCD remains open 457 …”

Section: A10 – Cross‐reactive Carbohydrate Determinantsmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

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Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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“…7 The evolutionistic meaning and the inducing factors of the IgE response to CCD are still hotly debated. 15 Within a Ugandan population endemically infected by Schistosoma mansoni, the prevalence of IgE to CCD reached 40% and was inversely associated with asthma, 16 suggesting their protective role in the context of the immune response against helminths. In a European, westernized population, the prevalence of IgE to CCD increased with age and an onset in childhood was hypothesized.…”

Section: Key Messagesmentioning

confidence: 99%

“…11 Allergen molecules of pollen, insect venom and mites express CCDs that are recognized in vitro by IgE antibodies of allergic patients, 3 but it is still unclear which molecule of these allergen sources is responsible for the induction of these antibodies and what is the mechanism of induction. 15 Studies of the IgE response to CCD in childhood that may address some of the above listed questions are lacking. To fill this knowledge gap, we examined the IgE response to CCD, both with a cross-sectional approach in a large cohort of Italian children affected by seasonal allergic rhinitis (SAR), and with a longitudinal approach in a birth cohort of German children.…”

Section: Key Messagesmentioning

confidence: 99%

IgE to cross‐reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins

Potapova,

Tripodi,

Panetta

et al. 2024

Clin Experimental Allergy

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BackgroundIgE antibodies to cross‐reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen‐specific IgE tests in vitro. Their prevalence and levels have been so far cross‐sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood.MethodsWe examined CCD with a cross‐sectional approach in 1263 Italian pollen allergic children (Panallergen in Paediatrics, PAN‐PED), as well as with a longitudinal approach in 612 German children (Multicenter Allergy Study, MAS), whose cutaneous and IgE sensitization profile to a broad panel of allergen extracts and molecules was already known. The presence and levels of IgE to CCD were examined in the sera of both cohorts using bromelain (MUXF3) as reagent and a novel chemiluminescence detection system, operating in a solid phase of fluorescently labelled and streptavidin‐coated paramagnetic microparticles (NOVEOS, HYCOR, USA).ResultsIgE to CCD was found in 22% of the Italian pollen allergic children, mainly in association with an IgE response to grass pollen. Children with IgE to CCD had higher total IgE levels and were sensitized to more allergenic molecules of Phleum pratense than those with no IgE to CCD. Among participants of the German MAS birth cohort study, IgE to CCD emerged early in life (even at pre‐school age), with IgE sensitization to group 1 and 4 allergen molecules of grasses, and almost invariably persisted over the full observation period.ConclusionsOur results contribute to dissect the immunological origins, onset, evolution and risk factors of CCD‐sIgE response in childhood, and raise the hypothesis that group 1 and/or 4 allergen molecules of grass pollen are major inducers of these antibodies through an antigen‐specific, T‐B cell cognate interaction.

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IgE to cross-reactive carbohydrate determinants: Origins, functions, and confounding role in nPhl p 4-IgE assays

Cited by 4 publications

References 10 publications

Molecular allergology and its impact in specific allergy diagnosis and therapy

Molecular allergology and its impact in specific allergy diagnosis and therapy

EAACIMolecular Allergology User's Guide 2.0

IgE to cross‐reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins

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