IgE-specific suppressor factors in normal human serum

Leung, Donald Y.M.; Brożek, Celestyn M.; Frankel, R; Geha, Raif S.

doi:10.1016/0090-1229(84)90277-0

Cited by 30 publications

(5 citation statements)

References 25 publications

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“…IgE-binding factors (IgE-BF) are glycoprotein molecules with an affinity for IgE and the ability to regulate IgE synthesis (1)(2)(3). Although rat IgE-BF were first discovered, some investigators have reported that IgE-BF are also contained in the human serum (4,5). IgE-BF which enhance IgE synthesis (IgE-potentiating factors) have been described to be produced by T lymphocytes bearing low affinity Fc receptors for IgE (Fc^RII) in rats (6,7).…”

mentioning

confidence: 99%

IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children

Kim

Mayumi

Mikawa

1992

Pediatric Allergy Immunology

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We correlated serum IgE, interleukin 4 (IL4) and soluble low affinity Fc receptor for IgE (sFcɛRII) in atopic and nonatopic children. Serum sFcɛRII was significantly higher in atopic than in nonatopic children (0‐2 yr). Serum sFcɛRII correlated closely with serum IgE in infants, but not in older children. To study further the characteristics of IgE synthesis in infants, we measured the serum level of IL4, which has been demonstrated to enhance the production of both IgE and sFcɛRIIin vitro. Serum IL4 was significantly higher in atopic than in nonatopic infants, but there was no significant difference between atopic and nonatopic older children. These results suggest that IL4 plays an important role in the regulation of IgE synthesis in infants and that IgE synthesis in older children might be modulated by other factors.

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confidence: 99%

IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children

Kim

Mayumi

Mikawa

1992

Pediatric Allergy Immunology

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“…Supernatants from T cells derived from patients with severe atopy (13,14), parasitic diseases (6), and the hyperimmunoglobulin E recurrent-infection (Job) syndrome (HIE) (4) induce IgE production in vitro. In contrast, soluble factors from T cells of normal nonatopic individuals suppress the IgE response (15,16).…”

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confidence: 99%

Regulation of immunoglobulin production in hyperimmunoglobulin E recurrent-infection syndrome by interferon gamma.

King

Gallin

Malech

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

101

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The hyperimmunoglobulin E recurrent-infection (Job) syndrome (HIE) is a congenital disorder characterized by high serum IgE, chronic eczematoid dermatitis, and recurrent infections. We examined the effect of interferon Y (IFN-y) on excessive IgE production in HIE patients. Spontaneous in vitro production of IgE by peripheral blood mononuclear cells from HIE patients was elevated compared to normal individuals and correlated with serum IgE. In 9 of 13 patients, IgE production by peripheral blood mononuclear cells was inhibited by 50% by IFN-y at 100-1000 units/ml, whereas inhibition by IFN-y at 104 units/ml ranged from 67 to 93% for these 9 patients. IFN-y also inhibited IgG1, IgG3, and IgG4 production by B lymphocytes without inhibiting IgG2 production. IFN-y was administered subcutaneously to 5 HIE patients. After 2 weeks of treatment with IFN-y (0.05 mg/M2) at three doses per week given on alternate days, peripheral blood mononuclear cells from all 5 HIE patients decreased spontaneous in vitro IgE production (27-62% decrease) with no change in IgG and IgM. One patient had a 58% decrease in serum IgE and another patient had a 50% decrease in serum IgE after the IFN-y was increased to 0.1 mg/M2 for three doses per week for a month. In both patients, serum IgE returned to pre-IFN-y-challenge levels 1-3 months after completion of treatment, and in vivo IFN-y did not affect serum IgG and IgM, although serum IgG4 decreased with changes in serum IgE. Our studies demonstrate that IFN-y can regulate production of IgE and some IgG subclasses in humans.

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“…At least 3 categories of IgE-BFs have been identified. They are T-cell-derived IgE-BFs including potentiating factors (IgE-PFs) [19] and suppressor factors (IgE-SFs) [12] and B-celi-derived IgE-BFs [21]. The former two IgE-BFs are exclusively secreted by CD4-P T cells and are further governed by anothertwo T-cell-derived lymphokines called glycosylation-enhancing factors (GEF) and glycosylationinhibiting factors (GIF) [22].…”

Section: Discussionmentioning

confidence: 99%

“…This was done according to the method used by Leung et al [12], Briefly, serum samples from patients and normal controls were filtered twice through Diaflo CF50A membranes (cutoff point: 50,000; Amicon Corp., Lexington, Mass., USA). These filtrates were then dialyzed in Spectrapor 2 membranes (cutoff point: 2,000; Spectrum Medical Industries Inc., Los Angeles, Calif, USA) at 4 C against a large excess of RPMI 1640 culture medium and filtered through a 0.45-um Millipore filter.…”

Section: Preparation O F Serum Filtrates Containing Ig E Suppressor Amentioning

confidence: 99%

Immunoglobulin-E-Specific Suppressor Factors in Primary Glomerulonephritis with Nephrotic Syndrome

Shu

Lian²,

Lu³

et al. 1992

Nephron

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Human immunoglobulin (Ig) E synthesis is regulated by T-cell-derived binding factors which include potentiating factors and suppressor factors (IgE-SFs) and B-cell-derived factors. Seventeen cases of primary glomerulonephritis (GN) with nephrotic syndrome and high serum IgE were studied for their serum IgE-SFs. These include 8 cases of minimal-change disease (MCD), 3 cases of IgM nephropathy, 4 cases of focal segmental glomerulosclerosis, and 2 cases of IgA nephropathy, aged between 20 and 60 years (mean: 37.2). A significantly lower activity of these factors was noted in the patient group as shown by a lower overall inhibition rate on in vitro IgE synthesis (median: 22.9 vs. 53.2%, p < 0.05). Some of them even exhibited an enhancing activity in their serum as shown by a negative inhibition rate. These findings suggest that there is a T cell disorder in some of the primary GNs with high serum IgE, especially in MCD, which causes an abnormal regulation of IgE synthesis.

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IgE-specific suppressor factors in normal human serum

Cited by 30 publications

References 25 publications

IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children

IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children

Regulation of immunoglobulin production in hyperimmunoglobulin E recurrent-infection syndrome by interferon gamma.

Immunoglobulin-E-Specific Suppressor Factors in Primary Glomerulonephritis with Nephrotic Syndrome

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IgE-specific suppressor factors in normal human serum

Cited by 30 publications

References 25 publications

IgE, IL4, and soluble FcɛRII in the serum of atopic and nonatopic children

IgE, IL4, and soluble FcɛRII in the serum of atopic and nonatopic children

Regulation of immunoglobulin production in hyperimmunoglobulin E recurrent-infection syndrome by interferon gamma.

Immunoglobulin-E-Specific Suppressor Factors in Primary Glomerulonephritis with Nephrotic Syndrome

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IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children

IgE, IL4, and soluble Fc_ɛRII in the serum of atopic and nonatopic children