IgE serum level: A prognostic marker for AIDS in HIV-infected adults?

Rancinan, Corinne; Morlat, Philippe; Chêne, Geneviève; Guez, S.; Baquey, A.; Beylot, J; Salamon, Roger

doi:10.1016/s0091-6749(98)70107-1

Cited by 27 publications

(32 citation statements)

References 5 publications

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“…High serum IgE in individuals with AIDS were seen at the beginning of the epidemic and confirmed years later by other studies (63)(64)(65)(66)(67)(68)(69). Some studies have found a relationship between high IgE levels and CD4 + T lymphocyte count < 300 cells/ mm 3 (64)(65)67).…”

Section: Discussionsupporting

confidence: 55%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

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Section: Discussionsupporting

confidence: 55%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…ϩ -T-cell counts develop an allergic phenotype characterized by an elevated serum level of IgE and eosinophilia (8,30,38,44,48). The etiology of the allergic response is unknown (7,15), but recent evidence implicates HIV-1 gp120 in inducing IL-4 and IL-13 release from Fc⑀RI ϩ cells, such as basophils, by binding to the VH3 region of bound IgE (31,37).…”

Section: Vol 74 2006 Eosinophils In Human Schistosome Infections 2173mentioning

confidence: 99%

Correlation between Eosinophils and Protection against Reinfection withSchistosoma mansoniand the Effect of Human Immunodeficiency Virus Type 1 Coinfection in Humans

et al. 2006

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Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to reinfection while others remain highly susceptible. We sought to characterize immune correlates associated with host protection in this population. Previous studies have demonstrated an association of peripheral eosinophilia with resistance to reinfection with schistosomes. Thus, we investigated the relationship between the percentage of circulating eosinophils and the effect of human immunodeficiency virus type 1 (HIV-1) coinfection on the susceptibility of the car washers to reinfection with schistosomes. Elevated percentages of circulating eosinophils were associated with resistance to reinfection by S. mansoni in HIV-1-seronegative persons. In the HIV-1-seropositive cohort, low CD4؉ -T-cell counts were associated with a less intense eosinophilia. Moreover, eosinophils from the car washers expressed high levels of Fc⑀RI ␤ chain, a molecule important in immunoglobulin E (IgE)-mediated immunity. Levels of Fc⑀RI ␤ chain expression correlated with serum levels of total and antigen-specific IgE for HIV-1-negative car washers, but this was not the case for individuals coinfected with HIV-1. Overall, these data further implicate eosinophils as having a potential role in development of protective immunity against schistosomes and suggest that changes associated with HIV-1 coinfection increase susceptibility to reinfection.Schistosomes are parasitic trematodes responsible for causing disease in over 200 million people worldwide (14). A better understanding of the immunologic components involved in the development of protection against infection is needed to lay the foundation for the advancement of efficacious vaccines (49). A common finding in many studies is that a high concentration of serum parasite-specific immunoglobulin E (IgE) is related to resistance against schistosomes (6,12,13,27,39). However, whether IgE is directly involved in protective mechanisms in vivo has not been elucidated, as IgE exerts its effector function through Fc⑀RI-expressing cells. Several studies have demonstrated an association between eosinophilia and host protection against schistosomes (2, 18, 45), although whether eosinophils express the high-affinity IgE receptor remains under debate (1,3,4,17,21,23,26,40,42,43). Purified human eosinophils are cytotoxic to schistosomula in vitro in the presence of parasite-specific IgE, with eosinophils from helminthinfected individuals having greater potency (11,16,23,50). These observations suggest that IgE and eosinophils are likely to have an important role in host protection against schistosomes.Our laboratory is conducting a longitudinal study on Schistosoma mansoni infections in a cohort of adult male Kenyan car washers who are occupationally exposed to infective cercariae in the waters along the shores of Lake Victoria (22). Over 200 men in this group have been actively monito...

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“…Studies in various geographical regions have reported elevated serum IgE concentrations in HIV-1-infected adults [21, 28, 29, 30, 31, 32, 33]and children [22, 23, 24, 25, 26, 27]. High IgE levels have been associated with disease progression in both children [22, 23, 24, 25, 26, 27]and adults [33, 34, 35, 36, 37, 38, 39, 40, 41, 42]and have been suggested as a marker of poor prognosis in these patients.…”

Section: Th1 and Th2 Responses In Hiv-1 Infectionmentioning

confidence: 99%

“…High IgE levels have been associated with disease progression in both children [22, 23, 24, 25, 26, 27]and adults [33, 34, 35, 36, 37, 38, 39, 40, 41, 42]and have been suggested as a marker of poor prognosis in these patients.…”

Section: Th1 and Th2 Responses In Hiv-1 Infectionmentioning

confidence: 99%

“…While there is no apparent relation between these two disorders, a number of features of HIV infection suggest that hypersensitivity arises in these patients. For example, the Th1 and Th2 cytokine profile is deranged in HIV-1 infection because of a shift towards Th2 cytokines [13, 14, 15, 16, 17, 18, 19, 20, 21], and serum IgE levels are raised in HIV-1-infected children [22, 23, 24, 25, 26, 27]and adults [21, 28, 29, 30, 31, 32, 33]. Moreover, HIV-1-infected patients have enhanced symptoms of allergic disorders [34, 35, 36]and HIV-1 antigens induce histamine release from basophils [4, 37, 38].…”

Section: Introductionmentioning

confidence: 99%

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Are Mast Cells MASTers in HIV-1 Infection?

Marone

Paulis

Florio

et al. 2001

Int Arch Allergy Immunol

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HIV-1 gp120 interacts with IgE V_H3⁺ on the surface of human basophils and mast cells (FcΕRI⁺ cells), acting as a viral immunoglobulin superantigen. gp120 from different clades induces mediator release from FcΕRI⁺ cells. gp120 also induces IL-4 and IL-13 synthesis in human basophils. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human FcΕRI⁺ cells. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells, interacting with CCR3. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human FcΕRI⁺ cells could be infected in vitro by M-tropic HIV-1 strains.

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IgE serum level: A prognostic marker for AIDS in HIV-infected adults?

Cited by 27 publications

References 5 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Correlation between Eosinophils and Protection against Reinfection withSchistosoma mansoniand the Effect of Human Immunodeficiency Virus Type 1 Coinfection in Humans

Are Mast Cells MASTers in HIV-1 Infection?

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