IgE sensitisation in relation to flow-independent nitric oxide exchange parameters

Malinovschi, Andreï; Janson, Christer; Holmkvist, Thomas; Norbäck, Dan; Meriläinen, Pekka; Högman, Marieann

doi:10.1186/1465-9921-7-92

Cited by 42 publications

(52 citation statements)

References 43 publications

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“…FeNO 50 was also related to FEV 1 . Atopy was related not only to increased FeNO 50 and J 0 aw NO but also to unadjusted Calv NO , which contradicts a previous study from our group (41). This might be explained by the population-based setting of the previous study and the relatively small size of the effect: a large population of patients with asthma as in the present study is probably required to find significant differences.…”

Section: Discussioncontrasting

confidence: 82%

Alveolar and exhaled NO in relation to asthma characteristics - effects of correction for axial diffusion

Heijkenskjöld-Rentzhog

Nordvall

Janson

et al. 2014

Allergy

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Adjusted CalvNO was not associated with any asthma characteristics studied in this large asthma cohort. However, both FeNO and unadjusted CalvNO related to asthma symptoms, lung function and bronchial responsiveness. We suggest a potential overadjustment by current TMAD-corrections, validated in healthy or unobstructed asthmatics. Further studies assessing axial diffusion in asthmatics with different degrees of airway obstruction and the validity of proposed TMAD-corrections are warranted.

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Section: Discussioncontrasting

confidence: 82%

Alveolar and exhaled NO in relation to asthma characteristics - effects of correction for axial diffusion

Heijkenskjöld-Rentzhog

Nordvall

Janson

et al. 2014

Allergy

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“…There was no significant interaction between sensitization and exposure. In adults with cat sensitization, FeNO did not change significantly with cat exposure (17,21). We also found that cat ownership was not associated with a change in FeNO.…”

Section: Discussionsupporting

confidence: 55%

“…Although there may be a volunteer bias, we avoided further selection influences that occur when subjects have been referred to a clinical setting. There may be misclassification on diagnoses, but we relied on the reported diagnosis of asthma and allergies by a physician, as described in previous reports (21,36). For the categorization of allergies with or without asthma, it would be preferable to confirm atopy using allergy skin testing, as had been performed in previous, somewhat smaller studies (2,37,38).…”

Section: Discussionmentioning

confidence: 99%

Effects of the Indoor Environment on the Fraction of Exhaled Nitric Oxide in School‐Aged Children

Kovesi

Dales

2009

Canadian Respiratory Journal

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BACKGROUND: The fractional concentration of exhaled nitric oxide (FeNO) appears to be a good marker for airway inflammation in children with asthma.OBJECTIVE: To evaluate the effect of environmental exposures on exhaled nitric oxide in a community sample of children.METHODS: The relationship among exhaled nitric oxide, underlying disease and home environmental exposures was examined using questionnaire data and measurement of exhaled nitric oxide in a cross-sectional study of 1135 children that included healthy children, and children with allergies and/or asthma who were attending grades 4 through 6 in Windsor, Ontario.RESULTS: Among healthy children, there was a positive association between FeNO and occupancy (P<0.02). Compared with forced air and hot water radiant heat, electric baseboard heating was associated with a significant increase of FeNO in healthy children (P=0.007) and children with allergies (P=0.043). FeNO was not associated with environmental tobacco smoke exposure or reported surface mold. The presence of pet dog(s), but not cats, was associated with a significantly lower FeNO in healthy children (P<0.001) and in children with reported allergies (P<0.001).CONCLUSIONS: The type of heating system, but not previously reported environmental tobacco smoke or mold exposure appears to affect exhaled nitric oxide in children. Exposure to different types of pets may have disparate effects on airway inflammation.

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“…Holm adjustments for multiple comparisons were also reported in the models described in Tables III and E5. Because atopy is related to FENO values, 21 a multiple logistic regression model not adjusted for hay fever (used as proxy for atopy in this study) was also reported (see Table E5). A P value of less than .05 was considered statistically significant.…”

Section: Statistical Analysesmentioning

confidence: 99%

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

Malinovschi¹,

Fonseca²,

Jacinto³

et al. 2013

Journal of Allergy and Clinical Immunology

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225

158

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Background: Fraction of exhaled nitric oxide (FENO) and blood eosinophil count (B-Eos) values, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known about the relation of these markers to reported wheeze and asthma events in a random population sample. Objectives: We sought to determine the individual and independent values of B-Eos and FENO in relation to wheeze, asthma diagnosis, and asthma events in a cross-sectional study. 3 ) values rendered an adjusted odds ratio of 4.5 of having wheeze, 5.1 of having asthma, 5.4 for asthma attacks, and 2.9 for asthma-related ED visits compared with normal FENO (<25 ppb) and B-Eos (<300 cells/mm

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IgE sensitisation in relation to flow-independent nitric oxide exchange parameters

Abstract: Background: A positive association between IgE sensitisation and exhaled NO levels has been found in several studies, but there are no reports on the compartment of the lung that is responsible for the increase in exhaled NO levels seen in IgE-sensitised subjects.

Cited by 42 publications

References 43 publications

Alveolar and exhaled NO in relation to asthma characteristics - effects of correction for axial diffusion

Alveolar and exhaled NO in relation to asthma characteristics - effects of correction for axial diffusion

Effects of the Indoor Environment on the Fraction of Exhaled Nitric Oxide in School‐Aged Children

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

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