IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

Pène, Jérôme; Rousset, F; Brière, Francine; Chrétien, Isabelle; Bonnefoy, Jean‐Yves; Spits, Hergen; Yokota, Takashi; Arai, Naoko; Arai, Kohei; Banchereau, Jacques

doi:10.1073/pnas.85.18.6880

Cited by 845 publications

(435 citation statements)

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“…The frequency of spleen cells that secreted IL-4 after stimulation with ␤gal was dramatically reduced by protective immunization with Ad vector, whereas IFN-␥ producing T cells had expanded. Since IL-4 is known as the promoter of IgE isotype switch, whereas in contrast IFN-␥ acts as an antagonist, 38,39 it is tempting to speculate that the shift in the balance of T cell subsets away from Th2-type (producing particularly IL-4) in favor of a Th1-type T lymphocyte response (with preferential production of IFN-␥) contributed to the inhibition of IgE Ab production observed in the vaccinated mice. Alternatively suppression of IgE Ab might be mediated by the observed induction of IFN-␥ secreting CD8 + effector T cells in AdCMV-␤gal immunized mice, since it was previously demonstrated that CD8 + CTL might possess inibitory capacity for IgE Ab production.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy

et al. 2002

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DNA-based immunization represents an attractive alternative approach to the current treatment of allergic diseases by specific immunotherapy with allergen extracts. In this study, we used a replication-deficient adenovirus vector (AdCMV), to examine the in vivo efficacy of preventive and therapeutic genetic immunization in a mouse model of type I allergy. Primary immunization with a recombinant adenovirus expressing the model antigen ␤-galactosidase (AdCMV-␤gal) induced a Th1 immune response (predominance of IgG2a antibodies, high frequency of IFN-␥ producing T cells) and large numbers of cytotoxic T lymphocytes. Prophylactic vaccination with AdCMV-␤gal abol-

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Section: Discussionmentioning

confidence: 99%

Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy

et al. 2002

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“…DC can produce immunostimulatory cytokines such as IFN-␣ or IL-12, which play important roles in T cell differentiation towards a type 1 helper T cell (Th1) response associated with cellular immunity. [26][27][28][29][30] Furthermore, like IL-12, IFN-␣ has been shown to mediate antiangiogenic effects in murine and human tumors.…”

Section: Discussionmentioning

confidence: 99%

Interferon-alpha gene therapy in combination with CD80 transduction reduces tumorigenicity and growth of established tumor in poorly immunogenic tumor models

et al. 1999

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Interferon-alpha (IFN-␣) or CD80 transduction of tumor of IFN-␣ and Neo cells or CD80 and Neo cells led to tumors cells individually reduces tumorigenicity and enhances associated with progressive growth. Induction of long-lastantitumor responses. Here, we report that the combination ing tumor immunity against WT tumor cells was demonof IFN-␣ and CD80 cancer gene therapy in poorly immunostrated by rejection of a subsequent rechallenge in 10 of genic murine tumor models, the colorectal adenocarcin-13 (MC38) and six of seven (MCA205) tumor-free mice. oma cell line MC38, and the methylcholanthrene-inducedThe therapeutic efficacy with established WT MC38 tumors fibrosarcoma cell line MCA205 reduces tumor growth more was shown when mice were treated with a vaccine conefficiently without affecting in vitro growth. Wild-type (WT), sisting of repetitive injections of IFN-␣-and CD80-transneomycin-resistance (Neo) gene-, or CD80-transduced duced MC38 cells into the contralateral flank (P Ͻ 0. 01). tumor cells grew progressively in all immunocompetentThis treatment was associated with accumulation of CD4 + , mice. In contrast, IFN-␣-transduced MC38 or MCA205 CD8 + cells and dendritic cells within the established tumor, cells were rejected in 13 of 15 and seven of 15 mice, demonstrating induction of antitumor immune responses. respectively. Synergistic effects were observed when Combination gene therapy using IFN-␣ and CD80 is IFN-␣-and CD80-transduced tumor cells were mixed and an effective immune therapy of cancer and could be inoculated. These admixed cells were rejected by 14 of 15 considered for clinical trials. (MC38) or seven of 15 mice (MCA205), whereas, a mixture

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“…Peripheral blood and bronchial TCC were selected from one atopic subject sensitized to house dust mites, according to a method previously described [7,21]. Briefly, PBMC were resuspended at 5 × 10 5 /ml in Iscove's medium (TechGen International, Les Ulis, France), supplemented as described by Yssel et al [7] and with 10% autologous serum from the same patient.…”

Section: Generation Of Tccmentioning

confidence: 99%

Different modulation by histamine of IL-4 and interferon-gamma (IFN-γ) release according to the phenotype of human Th0, Th1 and Th2 clones

Lagier

Lebel

Bousquet

et al. 1997

Clinical and Experimental Immunology

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SUMMARYHistamine, an important inflammatory mediator in allergic diseases and asthma, has been reported to have modulator effects on T cells, suggesting that the bronchial microenvironment may regulate the function of resident T cells. We examined the effect of histamine on the release of the Th2-associated cytokines IL-4 and IL-5 and the Th1-associated cytokine IFN-g by 30 CD4 + T cell clones from peripheral blood or bronchial biopsy of one atopic subject. Based on the IL-4/IFN-g ratio, the clones were ascribed to the Th2 (ratio > 1), Th0 (ratio Ն 0 . 1 and Յ 1) or Th1 (ratio < 0 . 1) phenotype. Histamine inhibited IFN-g production by Th1-like cells (P < 0 . 02, Kruskall-Wallis), especially from bronchial biopsy, but had no effect on IL-4 release. Regarding Th0 clones, histamine inhibited IL-4 production (P < 0 . 02) in a dose-dependent manner and slightly inhibited IFN-g production, but had no effect on Th2-like cells. Histamine had a heterogeneous and insignificant effect on IL-5 production. The H 2 -receptor antagonist ranitidine completely reversed the inhibition of IL-4 and IFN-g production, whereas the agonist dimaprit mimicked this effect. In contrast, H 1 -and H 3 -receptor agonists and antagonists had no significant effect. These data demonstrate that histamine has different effects on IL-4 and IFN-g release by T helper cells according to their phenotype via H 2 -receptors. This study extends the immunomodulatory effects of histamine which may contribute to the perpetuation of airway inflammation in asthma.

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IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

Abstract: The effect of human recombinant interleukin 4 (IL-4) on antibody production by normal peripheral blood mononuclear cells enriched for B cells was investigated.

Cited by 845 publications

References 29 publications

Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy

Efficacy of recombinant adenovirus as vector for allergen gene therapy in a mouse model of type I allergy

Interferon-alpha gene therapy in combination with CD80 transduction reduces tumorigenicity and growth of established tumor in poorly immunogenic tumor models

Different modulation by histamine of IL-4 and interferon-gamma (IFN-γ) release according to the phenotype of human Th0, Th1 and Th2 clones

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