IgE-mediated sensitisation, rhinitis and asthma from occupational exposures

Nielsen, Gunnar D.; Olsen, Ole; Larsen, Søren Thor; Løvik, Martinus; Poulsen, Lars K.; Glue, Christian; Brandorff, Nanna P.; Nielsen, Pia Juul

doi:10.1016/j.tox.2005.07.022

Cited by 53 publications

(40 citation statements)

References 111 publications

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“…This finding has clear relevance to health surveillance programs when deciding on the content of worker education programs. Previous evidence also supports the contribution of cigarette smoking [Barker et al, 1998;Nielsen et al, 2005] to sensitization to occupational allergens, although our findings conflict with previous data showing a non-significant reduced risk of sensitization to fungal a-amylase in current smokers [Nieuwenhuijsen et al, 1999].…”

Section: Discussioncontrasting

confidence: 89%

Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers

Harris-Roberts

Robinson

Waterhouse

et al. 2008

American J Industrial Med

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Section: Discussioncontrasting

confidence: 89%

Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers

Harris-Roberts

Robinson

Waterhouse

et al. 2008

American J Industrial Med

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“…In our study, statistically significant inverse correlation was found between CC16 and IgE in smoking smelters (Table 4). Statistically significant increase in IgE was found in smokers and former smokers in the group of smelters as compared to controls (data not shown), confirming adjuvant effects of smoking [67]. Animal studies showed that IgE were induced by Al hydroxide inhalation [68], or intratracheal instilation of Al silicate [69].…”

Section: Ijomeh 2006;19(4)mentioning

confidence: 64%

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Hałatek¹,

Trzcinka-Ochocka²,

Matczak³

et al. 2006

International Journal of Occupational Medicine and Environmental Health

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Objectives: Although some of the exposures in aluminum (Al) smelting have been well characterized, and respiratory disorders in aluminum production workers are well known, the relationship between internal aluminum loads and appropriate lung biomarkers have not been elucidated. The aim of our work was to carry out a comprehensive investigation in workers employed in the Aluminum Foundry Casting Department with special reference to currently existing hygiene standards, known as threshold limit values (TLV) based on aluminum effects on the respiratory system. The measurement of serum anti-inflammatory Clara cell protein (CC16) was employed as a peripheral marker of the lung epithelium function. Materials and Methods: A group of 50 casting smelters, 5 locksmiths, 11 sawyers and auxiliary workers exposed to dust containing 14% of aluminum, and a group of 42 controls were examined. Respiratory function tests were performed and forced volume capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), forced expiratory volume in the first percent (FEV 1 %), forced expiratory flows in 50% VC (FEV 50 ), and markers of foundry workers' exposure and body burden, Al concentration in the breathing zone, blood and urine, biomarkers of the effects of exposure, concentration of CC16 and hyaluronic acid (HA) in serum were determined in all examined workers. Additional measurements comprised determinations of serum iron (Fe) levels, myeloperoxidase (MPO), eosinophil cationic protein (ECP), immunoglobulin E (IgE), glutathione S-transferase (GST), and superoxide dismutase (SOD) activity in erythrocytes. Results: The group of casting smelters was characterized by the highest levels of aluminum in urine (Al-U) (43.7 mg L -1 ), high levels of MPO, ECP and IgE, high SOD activity, low CC16 levels, and low activity of GST. Lower Al-U excretion was observed in locksmiths (35.2 mg L -1 ) and sawyers (21.7 mg L -1 ). Serum CC16 proved to be the most sensitive biomarker, showing high inverse relationship with serum Al (Al-S) concentrations in casting smelters (p = 0.006). Conclusions: The study showed that in conditions of occupational exposure, dusts containing Al 2 O 3 < 1 mg m -3 cause changes in the respiratory system and biomarkers in serum, especially in CC16, connected with altered functioning of this system. Changes in concentrations of the examined biomarkers and also in respiratory parameters of the study subjects were observed when Al-U concentration was > 40 mg L -1 .

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“…This may result in an increased risk of allergic sensitization, at least for occupational allergens (124). However, the relationship between cigarette smoking and allergy in severe asthma is still debated: some studies identify smoking as a risk factor for allergic asthma (125), while others show a lower prevalence of atopic sensitization in smoking patients with severe asthma (121).…”

Section: Smokingmentioning

confidence: 99%

Allergy in severe asthma

Giacco

Bakırtaş

Bel

et al. 2016

Allergy

111

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It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.

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IgE-mediated sensitisation, rhinitis and asthma from occupational exposures

Cited by 53 publications

References 111 publications

Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers

Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers

Serum Clara Cell Protein as an Indicator of Pulmonary Impairment in Occupational Exposure at Aluminum Foundry

Allergy in severe asthma

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