IgE‐mediated (and food‐induced) intestinal disease

Ströbel, Stephan

doi:10.1111/j.1365-2222.1995.tb01123.x

Cited by 7 publications

(2 citation statements)

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“…Two weeks after sensitization, their serum antibody responses were assessed and expressed as mean titres Ϯ 1 SD. *P ¼ 0.02; **P ¼ 0.005; ***P < 0.005 neonatal mice and infants [5,32,33]. It is possible that abrogation of oral tolerance may predispose to food allergy.…”

Section: Discussionmentioning

confidence: 99%

Heat Denaturation of Egg‐White Proteins Abrogates the Induction of Oral Tolerance of Specific Th2 Immune Responses in Mice

Peng

Chang²,

Цай

et al. 1998

Scand J Immunol

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Human foods are usually prepared by cooking. Boiling of chicken egg-white (EW) led to decreased allergenicity, and abrogated intestinal uptake of immunoreactive ovalbumin (OVA) when fed to mice. Therefore, the effects of oral administration of boiled EW were examined further in BALB/c mice. Specific IgE, IgG 1 and IgG antibody responses were suppressed by raw EW, but not by EW boiled for 5 or 60 min, fed prior to sensitization with 10 mg OVA or 1 mg DNP-OVA in alum. Similar results were obtained when mice were sensitized with 10 mg conalbumin, ovomucoid or lysozyme in alum. BALB/c spleen cell proliferation and secretion of Th2 cytokines IL-4 and IL-5 during in vitro stimulation with OVA were also suppressed by feeding raw EW, but not by boiled EW. Although heat denaturation of proteins can minimize allergenicity, the present results suggest that over-cooking of proteins may affect their intestinal antigen processing and thus prevent the induction of oral tolerance.

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Section: Discussionmentioning

confidence: 99%

Heat Denaturation of Egg‐White Proteins Abrogates the Induction of Oral Tolerance of Specific Th2 Immune Responses in Mice

Peng

Chang²,

Цай

et al. 1998

Scand J Immunol

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“…IgE-mediated symptoms result following release of histamine, prostaglandins, leukotrienes, and cytokines by activated mast cells of basophils (Sampson, 1988a). Although several mechanisms have been documented during chronic (Curtis et al, 1990) and intermittent (Turner et al, 1990) antigen exposure in previously sensitized laboratory animals, reports of IgE-mediated damage on mucosal structure have been variable (Strobel, 1995). Differently than in other IgE-mediated allergic conditions, namely bronchial asthma (Spinozzi et al, 1997), intestinal symptoms in IgEmediated disease are not directly correlated with abnormal mucosal morphology Spinozzi et al, 1997).…”

Section: Pathophysiologymentioning

confidence: 99%

Heretical thoughts about food hypersensitivity: small bowel manometry as an objective way to document gut reactions

1997

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Background: Food hypersensitivity is a frequent complaint by both pediatric and adult subjects. However, notwithstanding patient' belief about`allergies' related to food stuffs, only a minority of them have actually such a diagnosis substantiated. Moreover, the diagnostic approach to these problems is cumbersome and unsatisfactory, and the objectivation of a food hypersensitivity is often dif®cult. Patients and methods: For these reasons we studied by means of small bowel manometry a small group of patients with food hypersensitivity, and showed abnormal fasting and postprandial ®ndings in those with the gut as a target organ on clinical grounds. Results: Manometric abnormalities were somewhat similar to those previously described in celiac disease, a well recognized food allergy disease. The possible usefulness of this technique in the investigative approach of food hypersensitivity is discussed.

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