IgE Levels, Atopy Markers and Hay Fever in Relation to Age, Sex and Smoking Status in a Normal Adult Swiss Population

Wüthrich, B; Schindler, Christian; Tc, Medici; Zellweger, J.P.; Leuenberger, P.

doi:10.1159/000237398

Cited by 128 publications

(122 citation statements)

References 6 publications

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“…Increase in total IgE levels is associated with both smoking and atopy, but separately [18,19]. Atopic markers such as increased specific IgE levels and immediate skin reactivity to common inhalants seem to be even less common in smokers [20]. Smoking has however been found to be a determinant of IgE-mediated sensitization to such occupational agents as psyllium [21] and platinum salts [22].…”

Section: Discussionmentioning

confidence: 99%

Host determinants for the development of allergy in apprentices exposed to laboratory animals

et al. 2001

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The aim of this study was to evaluate whether determinants of workrelated symptoms, skin sensitization and diseases differ between atopic and nonatopic subjects starting a career with exposure to laboratory animals (LA).A cohort of 417 apprentices in animal-health technology was prospectively followed during 32 or 44 months. The effect on the study outcomes of variables derived from questionnaire, skin reactivity, and lung function assessments at baseline were compared in atopic (n=212) and nonatopic (n=183) subjects.Eighty-five incident cases of sensitization to a LA-derived allergen were identified, 67 among atopic and 18 among nonatopic subjects. Baseline rhinitis symptoms in contact with pets and skin sensitization to pets were associated with the development of workrelated rhinoconjunctivitis (RC) symptoms in atopic subjects, whereas perannual rhinitis symptoms and having a PC20 (provocative concentration causing a 20% fall in forced expiratory volume in one second) ¡32 mg?mL -1 were associated in nonatopic subjects. Baseline rhinitis symptoms on contact with pets and a PC20 value ¡32 mg?mL -1 were significant determinants for developing sensitization to a specific allergen in atopic subjects only. Finally, baseline rhinitis symptoms in contact with pets and perannual rhinitis symptoms were associated with the development of occupational RC in atopic subjects, whereas in nonatopic subjects this was associated with having a PC20 value ¡32 mg?mL -1 . In conclusion, the determinants for the development of specific skin sensitization, symptoms and disease are different between atopic and nonatopic apprentices starting occupational exposure to laboratory-animal-derived allergens. Eur Respir J 2002; 19: 96-103 Exposure to laboratory animal-derived allergens carries a significant risk for immunoglobulin (Ig)-Emediated sensitization and development of oculonasal and respiratory symptoms as well as occupational rhinoconjunctivitis (RC) and asthma (OA) [1]. In a prospective assessment of 342 laboratory-animal workers, CULLINAN et al. [2] found that 46 (13%) developed skin reactivity to rat urine over a 3.5-yr period. In a prospective study of 417 apprentices starting exposure to laboratory animals and seen for a 32-to 44-month period, 85 (20%) incident cases of sensitization to at least one laboratory-animal-derived allergen were identified [3]. Interestingly, one third of these cases had probable OA as they also developed significant changes in bronchial hyperresponsiveness [4].As for most high molecular weight occupational allergens, almost all cross-sectional studies on animal workers to date [1] have shown atopy to be a risk factor for sensitization to animal-derived allergens. In a prospective assessment, the present authors found that atopy was a risk factor for skin sensitization although the relative risk (RR) was relatively low (RR=2.2, 95% confidence interval (CI)=1.2-3.9). The only other factor associated with the development of skin sensitization to animal-derived allergens was the presence of r...

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Section: Discussionmentioning

confidence: 99%

Host determinants for the development of allergy in apprentices exposed to laboratory animals

et al. 2001

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“…In three studies, the prevalence of self-reported nasal allergy symptoms was lower in smokers than in nonsmokers (55,715,723). In one study involving adolescents, smoking was found to increase the prevalence of rhinoconjunctivitis (729).…”

Section: Pollutantsmentioning

confidence: 95%

“…These materials are typically burnt in simple stoves with a very incomplete combustion. Consequently, women and young children are exposed to high levels of indoor air pollution every day, resulting in an estimated 1.5-2.0 million premature deaths a year and a high prevalence of COPD (698,710 (712)(713)(714)(715)(716) and the IgE sensitization to some occupational allergens (717)(718)(719). However, in the absence of longitudinal studies, it is difficult to establish whether smoking is a causative factor of allergy or not (714,720).…”

Section: Pollutantsmentioning

confidence: 99%

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Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,818

1,761

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“…Subjects were classified as having elevated IgE level if their total IgE level was greater than or equal to 100 IU/mL per current interpretation of total serum IgE values in screening for atopic diseases in adults. 26,27 Selection and genotyping of SPP1 polymorphisms…”

Section: Study Populationmentioning

confidence: 99%

Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population

Arjomandi

Galanter

Choudhry

et al. 2011

Pediatric Allergy, Immunology, and Pulmonology

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Recent studies have shown that osteopontin, a cytokine with suggested immunoregulatory functions, may contribute to pathogenesis of asthma. To determine whether single-nucleotide polymorphisms (SNPs) in SPP1, the gene encoding osteopontin, are associated with risk of asthma, we genotyped 6 known SNPs in SPP1 in the well-characterized Genetics of Asthma in Latino Americans population of 294 Mexican and 365 Puerto Rican parent-child asthma trios. The associations between SNPs and asthma or asthma-related phenotypes were examined by transmission disequilibrium tests as implemented in the family-based association test program. Three polymorphisms, 1 in exon 7 (rs1126616C) and 2 in the 3¢-untranslated region (rs1126772A and rs9138A) of SPP1, were associated with diagnosis of asthma, severity of asthma, asthma in subjects with elevated immunoglobulin E (IgE) (IgE > 100 IU/mL), and postbronchodilator FEV 1 in Puerto Ricans (P values = 0.00007-0.04). The CC genotype of rs1126616 conferred an odds ratio of 1.7 (95% CI = [1.3, 2.3], P value adjusted for multiple comparisons = 0.001) for asthma compared with the CT and TT genotypes. Furthermore, haplotype analysis identified rs1126616C-rs1126772A-rs9138A to be associated with an increased risk for asthma, severity of asthma, and asthma in subjects with elevated IgE (P = 0.03). There was no association between the SPP1 SNPs and asthma outcomes in Mexicans. Our findings suggest that the SPP1 gene is a risk factor for asthma and asthma-related phenotypes in Puerto Ricans, and are consistent with previous animal and human studies on the role of osteopontin in pathogenesis of asthma.

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IgE Levels, Atopy Markers and Hay Fever in Relation to Age, Sex and Smoking Status in a Normal Adult Swiss Population

Cited by 128 publications

References 6 publications

Host determinants for the development of allergy in apprentices exposed to laboratory animals

Host determinants for the development of allergy in apprentices exposed to laboratory animals

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population

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