IgE levels are negatively correlated with clinical response to ciclosporin in chronic spontaneous urticaria

Santiago, Luís; Ferreira, Bárbara Roque; Ramos, Leonor; Gonçalo, Margarida

doi:10.1111/bjd.17005

Cited by 18 publications

(20 citation statements)

References 8 publications

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“…Asero13 reported that the baseline duration of urticaria in 29 CSU patients, receiving 4 mg/kg/day of CsA, was not associated with clinical responses to CsA ( P = 0.252). This study has been supported by the studies of Santiago et al 22. and Endo et al 23.…”

Section: Resultssupporting

confidence: 85%

“…The author reported no relationship between baseline disease severity assessed by the urticaria activity score (UAS) and clinical CsA responses ( P = 0.906). These results are also supported by studies of Santiago et al 22. and Endo et al 23…”

Section: Resultssupporting

confidence: 84%

“…A total of 13 studies (404 patients with CSU and 200 healthy patients) met the eligibility criteria and were included in our systematic review (Figure). 671314151617181920212223 There were 1 RCT6; 8 open-labelled, prospective studies713151718202123; and 3 retrospective studies 141622. One study was an RCT at first, but was subsequently switched to an open-labelled, prospective study because of control failures 19.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies (2 open-labelled, prospective, control studies and 1 open-labelled, prospective study without controls) were identified 13, 17, 22. Recently, Santiago et al 22. studied 34 CSU patient receiving 3 mg/kg/day of CsA for 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

“… * For analysis of relationship between clinical factors—including prior histories of urticaria, disease severity and disease duration—4 studies were included13162223; † For the correlation between histamine-releasing activity and CsA response in CSU, 8 studies were included614151618192123, involving the ASST,6151618192123 and BHRA61416; ‡ Three studies showed a correlation between coagulation and inflammatory factors and the CsA response, involving D-dimer,13 CRP,131722 and ESR13; § Autoantibodies, including ANA,1622 TAs,131622 and other autoantibodies2223 were shown in 4 studies; ll Four studies showed a correlation between cytokines and the CsA response, involving immunophenotypical lymphocytes (CD3, CD4, CD56, CD57, CD19, CD19+CD5+, and CD19+CD23+)20; Igs, C3, C4, and CICs20; serum IgE22, 23; IL-2; IL-5; and TNF-α 7…”

Section: Methodsmentioning

confidence: 99%

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Factors Predicting the Response to Cyclosporin Treatment in Patients With Chronic Spontaneous Urticaria: A Systematic Review

Kulthanan

Subchookul

Hunnangkul

et al. 2019

Allergy Asthma Immunol Res

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Purpose This study aimed to systemically review literature relating to factors that could potentially predict a favorable response to cyclosporine A (CsA) treatment for chronic spontaneous urticaria (CSU). Methods A systematic literature review was done according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis recommendations. Results A total of 13 studies (404 patients with CSU and 200 healthy patients) were included. There were only 1 randomized controlled trial (RCT) and 12 non-RCTs. Our systematic review showed that positive autologous serum skin test results, positive baseline basophil histamine release assays, positive baseline basophil activation test responses, elevated baseline plasma D-dimer levels, elevated baseline serum interleukin (IL)-2, IL-5, and tumor necrosis factor-alpha (TNF-α) levels, and low baseline serum IgE levels might assist in predicting favorable CsA responses in CSU patients. Decreased plasma D-dimer levels; and decreased serum IL-2, IL-5, and TNF-α levels were reported to be correlated with clinical improvement after CsA treatment. Conclusions Since most positive results were from non-RCT articles and some data were still inconsistent, this systematic review identified no reliable practical biomarker for predicting CsA treatment response in patients with CSU. There were no positive predictors with good consistency and mechanical plausibility.

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Section: Resultssupporting

confidence: 85%

Section: Resultssupporting

confidence: 84%