IgE in Human Urine and Milk

Abstract

IgE was found in urine from healthy adult volunteers at very low levels (approximately 0.003-0.010 IU/ml), corresponding to a 24-h excrection rate of 3-16 IU. IgE was not detected in 36 out of 47 samples of milk and colostrum. In samples from six women the protein was present at low concentration 1-2 days postpartum but was not detected in later samples (usually day 5 or 6). Mammary secretions from four allergic donors were studied, and IgE was detected at low concentrations in samples from the two most severely affected individuals. The levels of IgE observed in both urine and milk suggest that there is no significant synthesis of the protein in either the urinary tract or in mammary tissue.

A Reappraisal of IgE Levels in Various Human Secretions by Particle Counting Immunoassay Combined with Pepsin Digestion

“…The results of our study of milk are much lower than those reported by others who used RIST [Bennich and Johansson 1971;Underdown et al, 1976: Gleich et al, 1977 but they agree with those obtained with DAB and PRIST [ Underdown et al, 1976;Turner et al, 1977;Bahna et al, 1982]. The correlation with IgA, which is known to be locally produced, the lack of correlation with serum IgE, the rather high milk/ serum IgE ratio (mean: 0.024; range: 0.005-0.045) in comparison to similar ratios reported for albumin (0.01) [Underdown et al, 1976] and IgG (0.008) [Brandtzaeget al, 1970] suggest a minor local produc tion of IgE in the mammary gland.…”

IGE and IGD in Human Colostrum and Plasma

“…studies have found either small or unmeasurable quantities (16,17). Our own studies confirm these observations, as IgE was detected in concentrations of 0.5-6 IU/ml in only 41% of the colostrum samples analyzed (16/39) and was undetectable (under 0.5 IU/ml) in the remainder.…”

“…Studies of IgE in milk have been few. Two investigators found either absent or low concentrations of IgE in milk compared with those in serum and concluded that local production or selective secretion by the mammary gland does not take place (16,17).…”

“…Studies of IgE in milk have been few. Two investigators found either absent or low concentrations of IgE in milk compared with those in serum and concluded that local production or selective secretion by the mammary gland does not take place (16,17).Although IgD levels have been examined in milk (7,15), simultaneous plasma and milk levels have not been compared using a technique as sensitive as radioimmunoassay (RIA). Because of the lack of such information we used RIA to study both IgE and IgD levels in milk and peripheral blood specimens obtained simultaneously from women postpartum.…”

IgE Lambda Monoclonal Gammopathy and Amyloidosis

“…Also, there is no significant IgE synthesis in the urinary tract [48]. It is known that IgE-synthesizing plasma ceils are present not only in lymphoid tissue but also IgE Gammopathy in the lamina propria o f mucous membranes [49], Taking into consideration the structure of the IgE molecule, passive transport of IgE through any membrane would be difficult.…”